@ARTICLE{Schlegel1987-og,
  title    = "Quantitative autoradiography of muscarinic and benzodiazepine
              receptors in the forebrain of the turtle, Pseudemys scripta",
  author   = "Schlegel, J R and Kriegstein, A R",
  abstract = "The distribution of muscarinic and benzodiazepine receptors was
              investigated in the turtle forebrain by the technique of in vitro
              receptor autoradiography. Muscarinic binding sites were labeled
              with 1 nM 3H-quinuclidinyl benzilate (3H-QNB), and benzodiazepine
              sites were demonstrated with the aid of 1 nM 3H-flunitrazepam
              (3H-FLU). Autoradiograms generated on 3H-Ultrofilm apposed to
              tissue slices revealed regionally specific distributions of
              muscarinic and benzodiazepine binding sites that are comparable
              with those for mammalian brain. Dense benzodiazepine binding was
              found in the anterior olfactory nucleus, the lateral and dorsal
              cortices, and the dorsal ventricular ridge (DVR), a structure
              with no clear mammalian homologue. Muscarinic binding sites were
              most dense in the striatum, accumbens, DVR, lateral geniculate,
              and the anterior olfactory nucleus. Cortical binding sites were
              studied in greater detail by quantitative analysis of
              autoradiograms generated by using emulsion-coated coverslips.
              Laminar gradients of binding were observed that were specific for
              each radioligand; 3H-QNB sites were most dense in the inner
              molecular layer in all cortical regions, whereas 3H-FLU binding
              was generally most concentrated in the outer molecular layer and
              was least dense through all layers in the dorsomedial cortex.
              Because pyramidal cells are arranged in register in turtle
              cortex, the laminar patterns of receptor binding may reflect
              different receptor density gradients along pyramidal cell
              dendrites.",
  journal  = "J Comp Neurol",
  volume   =  265,
  number   =  4,
  pages    = "521--529",
  month    =  nov,
  year     =  1987,
  address  = "United States",
  language = "en"
}

{"_id":"sML8FoK8i6ZmDjBZX","bibbaseid":"schlegel-kriegstein-quantitativeautoradiographyofmuscarinicandbenzodiazepinereceptorsintheforebrainoftheturtlepseudemysscripta-1987","author_short":["Schlegel, J R","Kriegstein, A R"],"bibdata":{"bibtype":"article","type":"article","title":"Quantitative autoradiography of muscarinic and benzodiazepine receptors in the forebrain of the turtle, Pseudemys scripta","author":[{"propositions":[],"lastnames":["Schlegel"],"firstnames":["J","R"],"suffixes":[]},{"propositions":[],"lastnames":["Kriegstein"],"firstnames":["A","R"],"suffixes":[]}],"abstract":"The distribution of muscarinic and benzodiazepine receptors was investigated in the turtle forebrain by the technique of in vitro receptor autoradiography. Muscarinic binding sites were labeled with 1 nM 3H-quinuclidinyl benzilate (3H-QNB), and benzodiazepine sites were demonstrated with the aid of 1 nM 3H-flunitrazepam (3H-FLU). Autoradiograms generated on 3H-Ultrofilm apposed to tissue slices revealed regionally specific distributions of muscarinic and benzodiazepine binding sites that are comparable with those for mammalian brain. Dense benzodiazepine binding was found in the anterior olfactory nucleus, the lateral and dorsal cortices, and the dorsal ventricular ridge (DVR), a structure with no clear mammalian homologue. Muscarinic binding sites were most dense in the striatum, accumbens, DVR, lateral geniculate, and the anterior olfactory nucleus. Cortical binding sites were studied in greater detail by quantitative analysis of autoradiograms generated by using emulsion-coated coverslips. Laminar gradients of binding were observed that were specific for each radioligand; 3H-QNB sites were most dense in the inner molecular layer in all cortical regions, whereas 3H-FLU binding was generally most concentrated in the outer molecular layer and was least dense through all layers in the dorsomedial cortex. Because pyramidal cells are arranged in register in turtle cortex, the laminar patterns of receptor binding may reflect different receptor density gradients along pyramidal cell dendrites.","journal":"J Comp Neurol","volume":"265","number":"4","pages":"521–529","month":"November","year":"1987","address":"United States","language":"en","bibtex":"@ARTICLE{Schlegel1987-og,\n title = \"Quantitative autoradiography of muscarinic and benzodiazepine\n receptors in the forebrain of the turtle, Pseudemys scripta\",\n author = \"Schlegel, J R and Kriegstein, A R\",\n abstract = \"The distribution of muscarinic and benzodiazepine receptors was\n investigated in the turtle forebrain by the technique of in vitro\n receptor autoradiography. Muscarinic binding sites were labeled\n with 1 nM 3H-quinuclidinyl benzilate (3H-QNB), and benzodiazepine\n sites were demonstrated with the aid of 1 nM 3H-flunitrazepam\n (3H-FLU). Autoradiograms generated on 3H-Ultrofilm apposed to\n tissue slices revealed regionally specific distributions of\n muscarinic and benzodiazepine binding sites that are comparable\n with those for mammalian brain. Dense benzodiazepine binding was\n found in the anterior olfactory nucleus, the lateral and dorsal\n cortices, and the dorsal ventricular ridge (DVR), a structure\n with no clear mammalian homologue. Muscarinic binding sites were\n most dense in the striatum, accumbens, DVR, lateral geniculate,\n and the anterior olfactory nucleus. Cortical binding sites were\n studied in greater detail by quantitative analysis of\n autoradiograms generated by using emulsion-coated coverslips.\n Laminar gradients of binding were observed that were specific for\n each radioligand; 3H-QNB sites were most dense in the inner\n molecular layer in all cortical regions, whereas 3H-FLU binding\n was generally most concentrated in the outer molecular layer and\n was least dense through all layers in the dorsomedial cortex.\n Because pyramidal cells are arranged in register in turtle\n cortex, the laminar patterns of receptor binding may reflect\n different receptor density gradients along pyramidal cell\n dendrites.\",\n journal = \"J Comp Neurol\",\n volume = 265,\n number = 4,\n pages = \"521--529\",\n month = nov,\n year = 1987,\n address = \"United States\",\n language = \"en\"\n}\n\n","author_short":["Schlegel, J R","Kriegstein, A R"],"key":"Schlegel1987-og","id":"Schlegel1987-og","bibbaseid":"schlegel-kriegstein-quantitativeautoradiographyofmuscarinicandbenzodiazepinereceptorsintheforebrainoftheturtlepseudemysscripta-1987","role":"author","urls":{},"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/f/EJMp3HRuxirjxpcXh/references.bib","dataSources":["sAFYeB74DpbdXM9NN","4zx9n2tbeLTix3Wxr","k3cdWrThyTh5o59Rm","hq9pebjzmsTuyxGGx","h8Atv2SAy4PmShg5j"],"keywords":[],"search_terms":["quantitative","autoradiography","muscarinic","benzodiazepine","receptors","forebrain","turtle","pseudemys","scripta","schlegel","kriegstein"],"title":"Quantitative autoradiography of muscarinic and benzodiazepine receptors in the forebrain of the turtle, Pseudemys scripta","year":1987}