Results from the French National Esophageal Atresia register: one-year outcome. Schneider, A., Blanc, S., Bonnard, A., Khen-Dunlop, N., Auber, F., Breton, A., Podevin, G., Sfeir, R., Fouquet, V., Jacquier, C., Lemelle, J., Lavrand, F., Becmeur, F., Petit, T., Poli-Merol, M., Elbaz, F., Merrot, T., Michel, J., Hossein, A., Lopez, M., Habonimana, E., Pelatan, C., De Lagausie, P., Buisson, P., de Vries, P., Gaudin, J., Lardy, H., Borderon, C., Borgnon, J., Jaby, O., Weil, D., Aubert, D., Geiss, S., Breaud, J., Echaieb, A., Languepin, J., Laplace, C., Pouzac, M., Lefebvre, F., Gottrand, F., & Michaud, L. Orphanet Journal of Rare Diseases, 9:206, December, 2014.
Results from the French National Esophageal Atresia register: one-year outcome [link]Paper  doi  abstract   bibtex   
BACKGROUND: The aim of the present national prospective population-based study was to assess the early morbidity of esophageal atresia (EA). METHODS: All 38 multidisciplinary French centers that care for patients with EA returned a specific questionnaire about the 1-year outcome for each patient. This information was centralized, checked, and entered into a database. RESULTS: From the total population of 307 EA patients born in 2008 and 2009, data about the 1-year outcome were obtained from 301 (98%) patients, of whom 4% were lost to follow-up and 5% died. Medical complications occurred in 34% of the patients: anastomotic leaks (8%), recurrent tracheoesophageal fistula (4%), and anastomotic stenosis (22%); all of the latter group needed dilation (median, 2 dilations/patient). A new hospitalization was required for 59% of patients (2.5 hospitalizations/patient) for digestive (52%) or respiratory (48%) reasons. Twelve percent of patients required antireflux surgery at a median age of 164 days (range, 33-398 days), and 1% underwent an aortopexy for severe tracheomalacia. The weight/age Z-score was -0.8 (range, -5.5 to 3.7 months) at 12 months. Fifteen percent of patients were undernourished at 12 months of age, whereas 37% presented with respiratory symptoms and 15% had dysphagia at the last follow-up. Significant independent factors associated with medical complications were anastomotic esophageal tension (p = .0009) and presence of a gastrostomy (p = .0002); exclusive oral feeding at discharge was associated with a decreased risk of complications (p = .007). CONCLUSIONS: Digestive and respiratory morbidities remain frequent during the first year of life and are associated with difficult anastomosis and lack of full oral feeding.
@article{schneider_results_2014,
	title = {Results from the {French} {National} {Esophageal} {Atresia} register: one-year outcome},
	volume = {9},
	issn = {1750-1172},
	shorttitle = {Results from the {French} {National} {Esophageal} {Atresia} register},
	url = {https://pubmed.ncbi.nlm.nih.gov/25496976/},
	doi = {10.1186/s13023-014-0206-5},
	abstract = {BACKGROUND: The aim of the present national prospective population-based study was to assess the early morbidity of esophageal atresia (EA).
METHODS: All 38 multidisciplinary French centers that care for patients with EA returned a specific questionnaire about the 1-year outcome for each patient. This information was centralized, checked, and entered into a database.
RESULTS: From the total population of 307 EA patients born in 2008 and 2009, data about the 1-year outcome were obtained from 301 (98\%) patients, of whom 4\% were lost to follow-up and 5\% died. Medical complications occurred in 34\% of the patients: anastomotic leaks (8\%), recurrent tracheoesophageal fistula (4\%), and anastomotic stenosis (22\%); all of the latter group needed dilation (median, 2 dilations/patient). A new hospitalization was required for 59\% of patients (2.5 hospitalizations/patient) for digestive (52\%) or respiratory (48\%) reasons. Twelve percent of patients required antireflux surgery at a median age of 164 days (range, 33-398 days), and 1\% underwent an aortopexy for severe tracheomalacia. The weight/age Z-score was -0.8 (range, -5.5 to 3.7 months) at 12 months. Fifteen percent of patients were undernourished at 12 months of age, whereas 37\% presented with respiratory symptoms and 15\% had dysphagia at the last follow-up. Significant independent factors associated with medical complications were anastomotic esophageal tension (p = .0009) and presence of a gastrostomy (p = .0002); exclusive oral feeding at discharge was associated with a decreased risk of complications (p = .007).
CONCLUSIONS: Digestive and respiratory morbidities remain frequent during the first year of life and are associated with difficult anastomosis and lack of full oral feeding.},
	language = {eng},
	journal = {Orphanet Journal of Rare Diseases},
	author = {Schneider, Anne and Blanc, Sébastien and Bonnard, Arnaud and Khen-Dunlop, Naziha and Auber, Frédéric and Breton, Anne and Podevin, Guillaume and Sfeir, Rony and Fouquet, Virginie and Jacquier, Catherine and Lemelle, Jean-Louis and Lavrand, Frédéric and Becmeur, François and Petit, Thierry and Poli-Merol, Marie-Laurence and Elbaz, Frédéric and Merrot, Thierry and Michel, Jean-Luc and Hossein, Allal and Lopez, Manuel and Habonimana, Edouard and Pelatan, Cécile and De Lagausie, Pascal and Buisson, Philippe and de Vries, Philine and Gaudin, Jean and Lardy, Hubert and Borderon, Corine and Borgnon, Joséphine and Jaby, Olivier and Weil, Dominique and Aubert, Didier and Geiss, Stephan and Breaud, Jean and Echaieb, Anis and Languepin, Jane and Laplace, Christophe and Pouzac, Myriam and Lefebvre, François and Gottrand, Frédéric and Michaud, Laurent},
	month = dec,
	year = {2014},
	keywords = {Esophageal Atresia, Female, Follow-Up Studies, France, Hospitalization, Humans, Infant, Infant, Newborn, Male, Population Surveillance, Registries, Time Factors, Treatment Outcome},
	pages = {206},
}
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