A prospective multicenter study on the outcome of type I collagen hydrogel-based autologous chondrocyte implantation (CaReS) for the repair of articular cartilage defects in the knee.

A prospective multicenter study on the outcome of type I collagen hydrogel-based autologous chondrocyte implantation (CaReS) for the repair of articular cartilage defects in the knee. Schneider, U., Rackwitz, L., Andereya, S., Siebenlist, S., Fensky, F., Reichert, J., Loer, I., Barthel, T., Rudert, M., & Noth, U. The American journal of sports medicine, 39(12):2558–2565, December, 2011.
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BACKGROUND: The Cartilage Regeneration System (CaReS) is a novel matrix-associated autologous chondrocyte implantation (ACI) technique for the treatment of chondral and osteochondral lesions (Outerbridge grades III and IV). For this technology, no expansion of the chondrocytes in a monolayer culture is needed, and a homogeneous cell distribution within the gel is guaranteed. PURPOSE: To report a prospective multicenter study of matrix-associated ACI of the knee using a new type I collagen hydrogel (CaReS). STUDY DESIGN: Case series; Level of evidence, 4. METHODS: From 2003 to 2008, 116 patients (49 women and 67 men; mean age, 32.5 +/- 8.9 years) had CaReS implantation of the knee in 9 different centers. On the basis of the International Cartilage Repair Society (ICRS) Cartilage Injury Evaluation Package 2000, the International Knee Documentation Committee (IKDC) score, pain score (visual analog scale [VAS]),

@article{schneider_prospective_2011,
	title = {A prospective multicenter study on the outcome of type {I} collagen hydrogel-based  autologous chondrocyte implantation ({CaReS}) for the repair of articular cartilage defects in the knee.},
	volume = {39},
	doi = {10.1177/0363546511423369},
	abstract = {BACKGROUND: The Cartilage Regeneration System (CaReS) is a novel matrix-associated autologous chondrocyte implantation (ACI) technique for the treatment of chondral and osteochondral lesions (Outerbridge grades III and IV).  For this technology, no expansion of the chondrocytes in a monolayer culture is needed, and a homogeneous cell distribution within the gel is guaranteed. PURPOSE: To report a prospective multicenter study of matrix-associated ACI of the knee using a new type I collagen hydrogel (CaReS). STUDY DESIGN: Case series; Level of evidence, 4. METHODS: From 2003 to 2008, 116 patients (49 women and 67 men; mean age, 32.5 +/- 8.9 years) had CaReS implantation of the knee in 9 different centers. On the basis of the International Cartilage Repair Society (ICRS) Cartilage Injury Evaluation Package 2000, the International Knee Documentation Committee (IKDC) score, pain score (visual analog scale [VAS]),},
	language = {eng},
	number = {12},
	journal = {The American journal of sports medicine},
	author = {Schneider, Ulrich and Rackwitz, Lars and Andereya, Stefan and Siebenlist, Sebastian and Fensky, Florian and Reichert, Johannes and Loer, Ingo and Barthel, Thomas and Rudert, Maximilian and Noth, Ulrich},
	month = dec,
	year = {2011},
	pmid = {21984690},
	keywords = {Adult, Arthroplasty, Subchondral/adverse effects/*methods, Chondrocytes/*transplantation, Collagen/*therapeutic use, Female, Humans, Hydrogels/*therapeutic use, Knee Injuries/*surgery, Knee Joint/*surgery, Male, Pain, Postoperative, Patient Satisfaction, Prospective Studies, Severity of Illness Index, Transplantation, Autologous, Young Adult},
	pages = {2558--2565},
}

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