@article{594094,
  abstract     = {{OBJECTIVE: Hysterectomy with concomitant cervical intraepithelial neoplasia (CIN), is often considered a definitive treatment for CIN, but development of subsequent vaginal intraepithelial neoplasia (VAIN) is known to range from 0.9% to 6.8%.

STUDY DESIGN: In a retrospective analysis of 3030 women with CIN2+ without history of VAIN in the University Hospital Gasthuisberg, Leuven, Belgium, from January 1989 until December 2003, we identified 125 women who underwent a hysterectomy within 6 months after diagnosis of CIN2+ and reviewed their postoperative Papanicolaou smears.

RESULTS: Thirty-one patients (24.8%) were lost to follow-up. Seven of the 94 women in the follow-up group (7.4%) developed VAIN2+, of which 2 were invasive vaginal cancers. Median interval between hysterectomy and diagnosis of VAIN2+ was 35 months (5-103 months). Women with recurrence were significantly older (P = .003).

CONCLUSION: Hysterectomy may not be considered as a definitive therapy for CIN2+ because the incidence rate of subsequent VAIN2+ is as high as 7.4%.}},
  author       = {{Schokkaert, Silke and Poppe, Willy and Arbyn, Marc and Verguts, Tom and Verguts, Jasper}},
  issn         = {{0002-9378}},
  journal      = {{AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY}},
  keywords     = {{MANAGEMENT,SQUAMOUS-CELL CARCINOMA,vaginal intraepithelial neoplasia,Papanicolaou smears,cervical intraepithelial neoplasia,hysterectomy,CANCER,CONIZATION,SMEARS,WOMEN,RISK}},
  language     = {{eng}},
  number       = {{2}},
  publisher    = {{MOSBY-ELSEVIER}},
  title        = {{Incidence of vaginal intraepithelial neoplasia after hysterectomy for cervical intraepithelial neoplasia: a retrospective study}},
  url          = {{http://doi.org/10.1016/j.ajog.2008.02.026}},
  volume       = {{199}},
  year         = {{2008}},
}

{"_id":"2SMBiahjTP9WncxEn","bibbaseid":"schokkaert-poppe-arbyn-verguts-verguts-incidenceofvaginalintraepithelialneoplasiaafterhysterectomyforcervicalintraepithelialneoplasiaaretrospectivestudy-2008","authorIDs":["Jfp3F32EQDk4cKtQh"],"author_short":["Schokkaert, Silke","Poppe, W.","Arbyn, M.","Verguts, T.","Verguts, J."],"bibdata":{"bibtype":"article","type":"article","abstract":"OBJECTIVE: Hysterectomy with concomitant cervical intraepithelial neoplasia (CIN), is often considered a definitive treatment for CIN, but development of subsequent vaginal intraepithelial neoplasia (VAIN) is known to range from 0.9% to 6.8%. STUDY DESIGN: In a retrospective analysis of 3030 women with CIN2+ without history of VAIN in the University Hospital Gasthuisberg, Leuven, Belgium, from January 1989 until December 2003, we identified 125 women who underwent a hysterectomy within 6 months after diagnosis of CIN2+ and reviewed their postoperative Papanicolaou smears. RESULTS: Thirty-one patients (24.8%) were lost to follow-up. Seven of the 94 women in the follow-up group (7.4%) developed VAIN2+, of which 2 were invasive vaginal cancers. Median interval between hysterectomy and diagnosis of VAIN2+ was 35 months (5-103 months). Women with recurrence were significantly older (P = .003). CONCLUSION: Hysterectomy may not be considered as a definitive therapy for CIN2+ because the incidence rate of subsequent VAIN2+ is as high as 7.4%.","author":[{"firstnames":[],"propositions":[],"lastnames":["Schokkaert, Silke"],"suffixes":[]},{"propositions":[],"lastnames":["Poppe"],"firstnames":["Willy"],"suffixes":[]},{"propositions":[],"lastnames":["Arbyn"],"firstnames":["Marc"],"suffixes":[]},{"propositions":[],"lastnames":["Verguts"],"firstnames":["Tom"],"suffixes":[]},{"propositions":[],"lastnames":["Verguts"],"firstnames":["Jasper"],"suffixes":[]}],"issn":"0002-9378","journal":"AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY","keywords":"MANAGEMENT,SQUAMOUS-CELL CARCINOMA,vaginal intraepithelial neoplasia,Papanicolaou smears,cervical intraepithelial neoplasia,hysterectomy,CANCER,CONIZATION,SMEARS,WOMEN,RISK","language":"eng","number":"2","publisher":"MOSBY-ELSEVIER","title":"Incidence of vaginal intraepithelial neoplasia after hysterectomy for cervical intraepithelial neoplasia: a retrospective study","url":"http://doi.org/10.1016/j.ajog.2008.02.026","volume":"199","year":"2008","bibtex":"@article{594094,\n abstract = {{OBJECTIVE: Hysterectomy with concomitant cervical intraepithelial neoplasia (CIN), is often considered a definitive treatment for CIN, but development of subsequent vaginal intraepithelial neoplasia (VAIN) is known to range from 0.9% to 6.8%.\r\n\r\nSTUDY DESIGN: In a retrospective analysis of 3030 women with CIN2+ without history of VAIN in the University Hospital Gasthuisberg, Leuven, Belgium, from January 1989 until December 2003, we identified 125 women who underwent a hysterectomy within 6 months after diagnosis of CIN2+ and reviewed their postoperative Papanicolaou smears.\r\n\r\nRESULTS: Thirty-one patients (24.8%) were lost to follow-up. Seven of the 94 women in the follow-up group (7.4%) developed VAIN2+, of which 2 were invasive vaginal cancers. Median interval between hysterectomy and diagnosis of VAIN2+ was 35 months (5-103 months). Women with recurrence were significantly older (P = .003).\r\n\r\nCONCLUSION: Hysterectomy may not be considered as a definitive therapy for CIN2+ because the incidence rate of subsequent VAIN2+ is as high as 7.4%.}},\n author = {{Schokkaert, Silke and Poppe, Willy and Arbyn, Marc and Verguts, Tom and Verguts, Jasper}},\n issn = {{0002-9378}},\n journal = {{AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY}},\n keywords = {{MANAGEMENT,SQUAMOUS-CELL CARCINOMA,vaginal intraepithelial neoplasia,Papanicolaou smears,cervical intraepithelial neoplasia,hysterectomy,CANCER,CONIZATION,SMEARS,WOMEN,RISK}},\n language = {{eng}},\n number = {{2}},\n publisher = {{MOSBY-ELSEVIER}},\n title = {{Incidence of vaginal intraepithelial neoplasia after hysterectomy for cervical intraepithelial neoplasia: a retrospective study}},\n url = {{http://doi.org/10.1016/j.ajog.2008.02.026}},\n volume = {{199}},\n year = {{2008}},\n}\n\n","author_short":["Schokkaert, Silke","Poppe, W.","Arbyn, M.","Verguts, T.","Verguts, J."],"key":"594094","id":"594094","bibbaseid":"schokkaert-poppe-arbyn-verguts-verguts-incidenceofvaginalintraepithelialneoplasiaafterhysterectomyforcervicalintraepithelialneoplasiaaretrospectivestudy-2008","role":"author","urls":{"Paper":"http://doi.org/10.1016/j.ajog.2008.02.026"},"keyword":["MANAGEMENT","SQUAMOUS-CELL CARCINOMA","vaginal intraepithelial neoplasia","Papanicolaou smears","cervical intraepithelial neoplasia","hysterectomy","CANCER","CONIZATION","SMEARS","WOMEN","RISK"],"metadata":{"authorlinks":{"verguts, t":"https://www.cogcomneurosci.com/publications/publications_overview.html"}},"downloads":0},"bibtype":"article","biburl":"https://biblio.ugent.be/person/801001536697/publication/export?format=bibtex","creationDate":"2020-08-27T07:59:40.624Z","downloads":0,"keywords":["management","squamous-cell carcinoma","vaginal intraepithelial neoplasia","papanicolaou smears","cervical intraepithelial neoplasia","hysterectomy","cancer","conization","smears","women","risk"],"search_terms":["incidence","vaginal","intraepithelial","neoplasia","hysterectomy","cervical","intraepithelial","neoplasia","retrospective","study","schokkaert","poppe","arbyn","verguts","verguts"],"title":"Incidence of vaginal intraepithelial neoplasia after hysterectomy for cervical intraepithelial neoplasia: a retrospective study","year":2008,"dataSources":["TC7BryQp3aBdfCoH3"]}