Incidence of vaginal intraepithelial neoplasia after hysterectomy for cervical intraepithelial neoplasia: a retrospective study. Schokkaert, Silke, Poppe, W., Arbyn, M., Verguts, T., & Verguts, J. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, MOSBY-ELSEVIER, 2008.
Paper abstract bibtex OBJECTIVE: Hysterectomy with concomitant cervical intraepithelial neoplasia (CIN), is often considered a definitive treatment for CIN, but development of subsequent vaginal intraepithelial neoplasia (VAIN) is known to range from 0.9% to 6.8%. STUDY DESIGN: In a retrospective analysis of 3030 women with CIN2+ without history of VAIN in the University Hospital Gasthuisberg, Leuven, Belgium, from January 1989 until December 2003, we identified 125 women who underwent a hysterectomy within 6 months after diagnosis of CIN2+ and reviewed their postoperative Papanicolaou smears. RESULTS: Thirty-one patients (24.8%) were lost to follow-up. Seven of the 94 women in the follow-up group (7.4%) developed VAIN2+, of which 2 were invasive vaginal cancers. Median interval between hysterectomy and diagnosis of VAIN2+ was 35 months (5-103 months). Women with recurrence were significantly older (P = .003). CONCLUSION: Hysterectomy may not be considered as a definitive therapy for CIN2+ because the incidence rate of subsequent VAIN2+ is as high as 7.4%.
@article{594094,
abstract = {{OBJECTIVE: Hysterectomy with concomitant cervical intraepithelial neoplasia (CIN), is often considered a definitive treatment for CIN, but development of subsequent vaginal intraepithelial neoplasia (VAIN) is known to range from 0.9% to 6.8%.
STUDY DESIGN: In a retrospective analysis of 3030 women with CIN2+ without history of VAIN in the University Hospital Gasthuisberg, Leuven, Belgium, from January 1989 until December 2003, we identified 125 women who underwent a hysterectomy within 6 months after diagnosis of CIN2+ and reviewed their postoperative Papanicolaou smears.
RESULTS: Thirty-one patients (24.8%) were lost to follow-up. Seven of the 94 women in the follow-up group (7.4%) developed VAIN2+, of which 2 were invasive vaginal cancers. Median interval between hysterectomy and diagnosis of VAIN2+ was 35 months (5-103 months). Women with recurrence were significantly older (P = .003).
CONCLUSION: Hysterectomy may not be considered as a definitive therapy for CIN2+ because the incidence rate of subsequent VAIN2+ is as high as 7.4%.}},
author = {{Schokkaert, Silke and Poppe, Willy and Arbyn, Marc and Verguts, Tom and Verguts, Jasper}},
issn = {{0002-9378}},
journal = {{AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY}},
keywords = {{MANAGEMENT,SQUAMOUS-CELL CARCINOMA,vaginal intraepithelial neoplasia,Papanicolaou smears,cervical intraepithelial neoplasia,hysterectomy,CANCER,CONIZATION,SMEARS,WOMEN,RISK}},
language = {{eng}},
number = {{2}},
publisher = {{MOSBY-ELSEVIER}},
title = {{Incidence of vaginal intraepithelial neoplasia after hysterectomy for cervical intraepithelial neoplasia: a retrospective study}},
url = {{http://doi.org/10.1016/j.ajog.2008.02.026}},
volume = {{199}},
year = {{2008}},
}
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RESULTS: Thirty-one patients (24.8%) were lost to follow-up. Seven of the 94 women in the follow-up group (7.4%) developed VAIN2+, of which 2 were invasive vaginal cancers. Median interval between hysterectomy and diagnosis of VAIN2+ was 35 months (5-103 months). Women with recurrence were significantly older (P = .003). CONCLUSION: Hysterectomy may not be considered as a definitive therapy for CIN2+ because the incidence rate of subsequent VAIN2+ is as high as 7.4%.","author":[{"firstnames":[],"propositions":[],"lastnames":["Schokkaert, Silke"],"suffixes":[]},{"propositions":[],"lastnames":["Poppe"],"firstnames":["Willy"],"suffixes":[]},{"propositions":[],"lastnames":["Arbyn"],"firstnames":["Marc"],"suffixes":[]},{"propositions":[],"lastnames":["Verguts"],"firstnames":["Tom"],"suffixes":[]},{"propositions":[],"lastnames":["Verguts"],"firstnames":["Jasper"],"suffixes":[]}],"issn":"0002-9378","journal":"AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY","keywords":"MANAGEMENT,SQUAMOUS-CELL CARCINOMA,vaginal intraepithelial neoplasia,Papanicolaou smears,cervical intraepithelial neoplasia,hysterectomy,CANCER,CONIZATION,SMEARS,WOMEN,RISK","language":"eng","number":"2","publisher":"MOSBY-ELSEVIER","title":"Incidence of vaginal intraepithelial neoplasia after hysterectomy for cervical intraepithelial neoplasia: a retrospective study","url":"http://doi.org/10.1016/j.ajog.2008.02.026","volume":"199","year":"2008","bibtex":"@article{594094,\n abstract = {{OBJECTIVE: Hysterectomy with concomitant cervical intraepithelial neoplasia (CIN), is often considered a definitive treatment for CIN, but development of subsequent vaginal intraepithelial neoplasia (VAIN) is known to range from 0.9% to 6.8%.\r\n\r\nSTUDY DESIGN: In a retrospective analysis of 3030 women with CIN2+ without history of VAIN in the University Hospital Gasthuisberg, Leuven, Belgium, from January 1989 until December 2003, we identified 125 women who underwent a hysterectomy within 6 months after diagnosis of CIN2+ and reviewed their postoperative Papanicolaou smears.\r\n\r\nRESULTS: Thirty-one patients (24.8%) were lost to follow-up. Seven of the 94 women in the follow-up group (7.4%) developed VAIN2+, of which 2 were invasive vaginal cancers. Median interval between hysterectomy and diagnosis of VAIN2+ was 35 months (5-103 months). 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