Characterization of the P5 subfamily of P-type transport ATPases in mice. Schultheis, P., J., Hagen, T., T., O'Toole, K., K., Tachibana, A., Burke, C., R., McGill, D., L., Okunade, G., W., & Shull, G., E. Section Title: Biochemical Genetics, 323(3):731-738, 2004. abstract bibtex In mammals, the most poorly understood P-type ATPases are those of the P5 subfamily. To begin characterization of the mammalian P5-ATPases, BLAST searches of DNA sequence databases were performed. Five genes were identified in the mouse, human, dog, and rat genomes, and the coding sequences of the mouse genes, termed Atp13a1-Atp13a5, were detd. The intron/exon organization of Atp13a1 differs entirely from those of Atp13a2-5, which are closely related. Amino acid sequence comparisons between the five mouse and two yeast P5-ATPases suggest that Atp13a1 is orthologus to the yeast Cod1 gene and that Atp13a2-5 are orthologus to yeast Yor291w. Northern blot anal. showed that Atp13a1, Atp13a2, and Atp13a3 mRNAs were expressed in all mouse tissues, whereas Atp13a4 and Atp13a5 mRNAs were restricted to brain and stomach. While the substrate specificity of these transporters is unknown, their importance is underscored by the presence of homologs in fish, insects, worms, and other eukaryotes. [on SciFinder(R)]
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title = {Characterization of the P5 subfamily of P-type transport ATPases in mice.},
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year = {2004},
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notes = {Copyright (C) 2012 American Chemical Society (ACS). All Rights Reserved.; Section Code: 3-3; CA Section Cross-references: 7; CODEN: BBRCA9; CAS Registry Numbers: 9000-83-3 (ATPase) Role: BSU (Biological study, unclassified), PRP (Properties), BIOL (Biological study) (characterization of P5 subfamily of P-type transport ATPases in mice)},
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abstract = {In mammals, the most poorly understood P-type ATPases are those of the P5 subfamily. To begin characterization of the mammalian P5-ATPases, BLAST searches of DNA sequence databases were performed. Five genes were identified in the mouse, human, dog, and rat genomes, and the coding sequences of the mouse genes, termed Atp13a1-Atp13a5, were detd. The intron/exon organization of Atp13a1 differs entirely from those of Atp13a2-5, which are closely related. Amino acid sequence comparisons between the five mouse and two yeast P5-ATPases suggest that Atp13a1 is orthologus to the yeast Cod1 gene and that Atp13a2-5 are orthologus to yeast Yor291w. Northern blot anal. showed that Atp13a1, Atp13a2, and Atp13a3 mRNAs were expressed in all mouse tissues, whereas Atp13a4 and Atp13a5 mRNAs were restricted to brain and stomach. While the substrate specificity of these transporters is unknown, their importance is underscored by the presence of homologs in fish, insects, worms, and other eukaryotes. [on SciFinder(R)]},
bibtype = {article},
author = {Schultheis, Patrick J and Hagen, Tamara T and O'Toole, Kate K and Tachibana, Akiko and Burke, Charles R and McGill, Diana L and Okunade, Gbolahan W and Shull, Gary E},
journal = {Section Title: Biochemical Genetics},
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