@Article{schulz06influence,
  author      = {Schulz, E. and Karas, M. and Rosu, F. and Gabelica, V.},
  title       = {Influence of the matrix on analyte fragmentation in atmospheric pressure MALDI.},
  journal     = {J Am Soc Mass Spectrom},
  year        = {2006},
  volume      = {17},
  number      = {7},
  pages       = {1005--1013},
  abstract    = {In this paper, we report the measurement of the degree of analyte fragmentation in AP-MALDI as a function of the matrix and of the laser fluence. The analytes include p-OCH3-benzylpyridinium, three peptides containing the sequence EEPP (which cleave very efficiently at the E-P site), and three deoxynucleosides (dA, dG, and dC), which lose the neutral sugar to give the protonated base. We found that the matrix hardness/softness was consistent when comparing the analytes, with a consensus ranking from hardest to softest: CHCA > DHB > SA approximately THAP > ATT > HPA. However, the exact ranking can be fluence-dependent, for example between ATT and HPA. Our goal here was to provide the scientific community with a detailed dataset that can be used to compare with theoretical predictions. We tried to correlate the consensus ranking with different matrix properties: sublimation or decomposition temperature (determined using thermogravimetry), analyte initial velocity, and matrix proton affinity. The best correlation was found with the matrix proton affinity.},
  doi         = {10.1016/j.jasms.2006.03.009},
  keywords    = {Atmospheric Pressure; Biocompatible Materials, chemistry; Nucleosides, chemistry; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, methods},
  owner       = {kerstin},
  pii         = {S1044-0305(06)00270-4},
  pmid        = {16713286},
  timestamp   = {2015.08.31},
}

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The analytes include p-OCH3-benzylpyridinium, three peptides containing the sequence EEPP (which cleave very efficiently at the E-P site), and three deoxynucleosides (dA, dG, and dC), which lose the neutral sugar to give the protonated base. We found that the matrix hardness/softness was consistent when comparing the analytes, with a consensus ranking from hardest to softest: CHCA > DHB > SA approximately THAP > ATT > HPA. However, the exact ranking can be fluence-dependent, for example between ATT and HPA. Our goal here was to provide the scientific community with a detailed dataset that can be used to compare with theoretical predictions. We tried to correlate the consensus ranking with different matrix properties: sublimation or decomposition temperature (determined using thermogravimetry), analyte initial velocity, and matrix proton affinity. The best correlation was found with the matrix proton affinity.","doi":"10.1016/j.jasms.2006.03.009","keywords":"Atmospheric Pressure; Biocompatible Materials, chemistry; Nucleosides, chemistry; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, methods","owner":"kerstin","pii":"S1044-0305(06)00270-4","pmid":"16713286","timestamp":"2015.08.31","bibtex":"@Article{schulz06influence,\n author = {Schulz, E. and Karas, M. and Rosu, F. and Gabelica, V.},\n title = {Influence of the matrix on analyte fragmentation in atmospheric pressure MALDI.},\n journal = {J Am Soc Mass Spectrom},\n year = {2006},\n volume = {17},\n number = {7},\n pages = {1005--1013},\n abstract = {In this paper, we report the measurement of the degree of analyte fragmentation in AP-MALDI as a function of the matrix and of the laser fluence. The analytes include p-OCH3-benzylpyridinium, three peptides containing the sequence EEPP (which cleave very efficiently at the E-P site), and three deoxynucleosides (dA, dG, and dC), which lose the neutral sugar to give the protonated base. We found that the matrix hardness/softness was consistent when comparing the analytes, with a consensus ranking from hardest to softest: CHCA > DHB > SA approximately THAP > ATT > HPA. However, the exact ranking can be fluence-dependent, for example between ATT and HPA. Our goal here was to provide the scientific community with a detailed dataset that can be used to compare with theoretical predictions. We tried to correlate the consensus ranking with different matrix properties: sublimation or decomposition temperature (determined using thermogravimetry), analyte initial velocity, and matrix proton affinity. The best correlation was found with the matrix proton affinity.},\n doi = {10.1016/j.jasms.2006.03.009},\n keywords = {Atmospheric Pressure; Biocompatible Materials, chemistry; Nucleosides, chemistry; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, methods},\n owner = {kerstin},\n pii = {S1044-0305(06)00270-4},\n pmid = {16713286},\n timestamp = {2015.08.31},\n}\n\n","author_short":["Schulz, E.","Karas, M.","Rosu, F.","Gabelica, V."],"key":"schulz06influence","id":"schulz06influence","bibbaseid":"schulz-karas-rosu-gabelica-influenceofthematrixonanalytefragmentationinatmosphericpressuremaldi-2006","role":"author","urls":{},"keyword":["Atmospheric Pressure; Biocompatible Materials","chemistry; Nucleosides","chemistry; Reproducibility of Results; Sensitivity and Specificity; Spectrometry","Mass","Matrix-Assisted Laser Desorption-Ionization","methods"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://git.bio.informatik.uni-jena.de/fleisch/literature/raw/master/group-literature.bib","creationDate":"2019-11-19T16:50:42.627Z","downloads":0,"keywords":["atmospheric pressure; biocompatible materials","chemistry; nucleosides","chemistry; reproducibility of results; sensitivity and specificity; spectrometry","mass","matrix-assisted laser desorption-ionization","methods"],"search_terms":["influence","matrix","analyte","fragmentation","atmospheric","pressure","maldi","schulz","karas","rosu","gabelica"],"title":"Influence of the matrix on analyte fragmentation in atmospheric pressure MALDI.","year":2006,"dataSources":["C5FtkvWWggFfMJTFX"]}