IL-4R$α$ signalling in B cells and T cells play differential roles in acute and chronic atopic dermatitis. Scibiorek, M., Mthembu, N., Mangali, S., Ngomti, A., Ikwegbue, P., Brombacher, F., & Hadebe, S. Scientific Reports, 13(1):144, Nature Publishing Group, jan, 2023. ![IL-4R$α$ signalling in B cells and T cells play differential roles in acute and chronic atopic dermatitis [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Atopic dermatitis (AD) is a common pruritic inflammatory skin disease with complex environmental and genetic predisposing factors. Primary skin barrier dysfunction and aberrant T helper 2 (TH2) responses to common allergens, together with increased serum IgE antibodies, characterise the disease. B and T cells are essential in the disease manifestation, however, the exact mechanism of how these cells is involved is unclear. Targeting interleukin 4 receptor alpha (IL-4R$α$), an IL-4/IL-13 signalling axis, with dupilumab shows efficacy in AD. We investigated the importance of IL-4R$α$ signalling specifically on B and T cells during acute and chronic models of AD. We used House dust mite (HDM) and Ovalbumin (OVA) in chronic models and a low-calcemic analog of vitamin D (MC903) for acute models of AD. We used mb1creIL-4R$α$−/lox, iLCKcreIL-4R$α$−/lox, LCKcreIL-4R$α$−/lox, CD4creIL-4R$α$−/lox, Foxp3creIL-4R$α$−/lox and IL-4R$α$−/lox littermate controls. IL-4R$α$-responsive B cells were essential in serum IgE levels, but not in epidermal thickening in both chronic and acute models. IL-4R$α$-responsive T cells were essential in epidermal thickening in the pan-T cell, but not CD4 or CD8 T cells suggesting the importance of $γ$$δ$T cells during acute AD. Our results suggest that IL-4R$α$ responsiveness on innate T cells regulates acute atopic dermatitis, while on B cells it regulates IgE.
@article{Scibiorek2023,
abstract = {Atopic dermatitis (AD) is a common pruritic inflammatory skin disease with complex environmental and genetic predisposing factors. Primary skin barrier dysfunction and aberrant T helper 2 (TH2) responses to common allergens, together with increased serum IgE antibodies, characterise the disease. B and T cells are essential in the disease manifestation, however, the exact mechanism of how these cells is involved is unclear. Targeting interleukin 4 receptor alpha (IL-4R$\alpha$), an IL-4/IL-13 signalling axis, with dupilumab shows efficacy in AD. We investigated the importance of IL-4R$\alpha$ signalling specifically on B and T cells during acute and chronic models of AD. We used House dust mite (HDM) and Ovalbumin (OVA) in chronic models and a low-calcemic analog of vitamin D (MC903) for acute models of AD. We used mb1creIL-4R$\alpha$−/lox, iLCKcreIL-4R$\alpha$−/lox, LCKcreIL-4R$\alpha$−/lox, CD4creIL-4R$\alpha$−/lox, Foxp3creIL-4R$\alpha$−/lox and IL-4R$\alpha$−/lox littermate controls. IL-4R$\alpha$-responsive B cells were essential in serum IgE levels, but not in epidermal thickening in both chronic and acute models. IL-4R$\alpha$-responsive T cells were essential in epidermal thickening in the pan-T cell, but not CD4 or CD8 T cells suggesting the importance of $\gamma$$\delta$T cells during acute AD. Our results suggest that IL-4R$\alpha$ responsiveness on innate T cells regulates acute atopic dermatitis, while on B cells it regulates IgE.},
author = {Scibiorek, Martyna and Mthembu, Nontobeko and Mangali, Sandisiwe and Ngomti, Amkele and Ikwegbue, Paul and Brombacher, Frank and Hadebe, Sabelo},
doi = {10.1038/s41598-022-26637-6},
file = {:C$\backslash$:/Users/01462563/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Scibiorek et al. - 2023 - IL-4R$\alpha$ signalling in B cells and T cells play differential roles in acute and chronic atopic dermatitis.pdf:pdf},
isbn = {0123456789},
issn = {2045-2322},
journal = {Scientific Reports},
keywords = {CD4,CD8,Gammadelta T cells,Immunology,Interleukins,OA,OA{\_}PMC,T,cell receptor,fund{\_}ack,original,positive T cells},
mendeley-tags = {OA,OA{\_}PMC,fund{\_}ack,original},
month = {jan},
number = {1},
pages = {144},
pmid = {36599893},
publisher = {Nature Publishing Group},
title = {{IL-4R$\alpha$ signalling in B cells and T cells play differential roles in acute and chronic atopic dermatitis}},
url = {https://www.nature.com/articles/s41598-022-26637-6},
volume = {13},
year = {2023}
}
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