Histological validation of myocardial microstructure obtained from diffusion tensor magnetic resonance imaging. Scollan, D., Holmes, A., Winslow, R., & Forder, J. j-AJP, 275:H2308–H2318, 1998. bibtex @Article{RSM:Sco98,
author = "D.F. Scollan and A. Holmes and R. Winslow and J.
Forder",
title = "Histological validation of myocardial microstructure
obtained from diffusion tensor magnetic resonance
imaging",
journal = j-AJP,
year = "1998",
volume = "275",
pages = "H2308--H2318",
robnote = "Diffusion tensor magnetic resonance imaging (MRI) is a
possible new means of elucidating the anatomic
structure of the myocardium. It enjoys several
advantages over traditional histological approaches,
including the ability to rapidly measure fiber
organization in isolated, perfused, arrested hearts,
thereby avoiding fixation and sectioning of artifacts.
However, quantitative validation of this MRI method has
been lacking. Here, fiber orientations estimated in the
same locations in the same heart using both diffusion
tensor MRI and histology are compared in a total of two
perfused rabbit hearts. Fiber orientations were
statistically similar for both methods and differed on
average by 12 degrees at any single location. This is
similar to the 10 degrees uncertainty in fiber
orientation achieved with histology. In addition,
imaging studies performed in a total of seven hearts
support a level of organization beyond the myofiber,
the recently described laminar organization of the
ventricular myocardium. Important paper for using
diffusion tensor imaging to image cardiac structure",
bibdate = "Sun Nov 19 13:36:14 2000",
}
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