Model-based and model-free decisions in alcohol dependence. Sebold, M., Deserno, L., Nebe, S., Schad, D. J., Garbusow, M., Hägele, C., Keller, J., Jünger, E., Kathmann, N., Smolka, M., Rapp, M. A., Schlagenhauf, F., Heinz, A., & Huys, Q. J M. Neuropsychobiology, 70(2):122–131, 2014. Publisher: Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité Universitätsmedizin Berlin, Berlin, Germany.![Model-based and model-free decisions in alcohol dependence. [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Human and animal work suggests a shift from goal-directed to habitual decision-making in addiction. However, the evidence for this in human alcohol dependence is as yet inconclusive.Twenty-six healthy controls and 26 recently detoxified alcohol-dependent patients underwent behavioral testing with a 2-step task designed to disentangle goal-directed and habitual response patterns.Alcohol-dependent patients showed less evidence of goal-directed choices than healthy controls, particularly after losses. There was no difference in the strength of the habitual component. The group differences did not survive controlling for performance on the Digit Symbol Substitution Task.Chronic alcohol use appears to selectively impair goal-directed function, rather than promoting habitual responding. It appears to do so particularly after nonrewards, and this may be mediated by the effects of alcohol on more general cognitive functions subserved by the prefrontal cortex. © 2014 S. Karger AG, Basel.
@article{sebold_model-based_2014,
title = {Model-based and model-free decisions in alcohol dependence.},
volume = {70},
url = {http://dx.doi.org/10.1159/000362840},
doi = {10.1159/000362840},
abstract = {Human and animal work suggests a shift from goal-directed to habitual decision-making in addiction. However, the evidence for this in human alcohol dependence is as yet inconclusive.Twenty-six healthy controls and 26 recently detoxified alcohol-dependent patients underwent behavioral testing with a 2-step task designed to disentangle goal-directed and habitual response patterns.Alcohol-dependent patients showed less evidence of goal-directed choices than healthy controls, particularly after losses. There was no difference in the strength of the habitual component. The group differences did not survive controlling for performance on the Digit Symbol Substitution Task.Chronic alcohol use appears to selectively impair goal-directed function, rather than promoting habitual responding. It appears to do so particularly after nonrewards, and this may be mediated by the effects of alcohol on more general cognitive functions subserved by the prefrontal cortex. © 2014 S. Karger AG, Basel.},
language = {eng},
number = {2},
journal = {Neuropsychobiology},
author = {Sebold, Miriam and Deserno, Lorenz and Nebe, Stefan and Schad, Daniel J. and Garbusow, Maria and Hägele, Claudia and Keller, Jürgen and Jünger, Elisabeth and Kathmann, Norbert and Smolka, Michael and Rapp, Michael A. and Schlagenhauf, Florian and Heinz, Andreas and Huys, Quentin J M.},
year = {2014},
pmid = {25359492},
note = {Publisher: Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité Universitätsmedizin Berlin, Berlin, Germany.},
pages = {122--131},
}
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