Genetic analysis of mecillinam-resistant mutants of Caulobacter crescentus deficient in stalk biosynthesis. Seitz, L C & Brun, Y V Journal of Bacteriology, 180(19):5235--5239, October, 1998.
Genetic analysis of mecillinam-resistant mutants of Caulobacter crescentus deficient in stalk biosynthesis [link]Paper  abstract   bibtex   
Stalk synthesis in Caulobacter crescentus is a developmentally controlled and spatially restricted event that requires the synthesis of peptidoglycan at the stalk-cell body junction. We show that the beta-lactam antibiotic mecillinam prevents stalk synthesis by inhibiting stalk elongation. In addition, mecillinam causes an increase in the diameter of the stalk at the stalk-cell body junction. We describe two mutations that confer resistance to mecillinam and that prevent stalk elongation. These mutations are probably allelic, and they map to a locus previously not associated with stalk synthesis.
@article{seitz_genetic_1998,
	title = {Genetic analysis of mecillinam-resistant mutants of {Caulobacter} crescentus deficient in stalk biosynthesis},
	volume = {180},
	issn = {0021-9193},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/9748460},
	abstract = {Stalk synthesis in Caulobacter crescentus is a developmentally controlled and spatially restricted event that requires the synthesis of peptidoglycan at the stalk-cell body junction. We show that the beta-lactam antibiotic mecillinam prevents stalk synthesis by inhibiting stalk elongation. In addition, mecillinam causes an increase in the diameter of the stalk at the stalk-cell body junction. We describe two mutations that confer resistance to mecillinam and that prevent stalk elongation. These mutations are probably allelic, and they map to a locus previously not associated with stalk synthesis.},
	number = {19},
	urldate = {2009-05-03TZ},
	journal = {Journal of Bacteriology},
	author = {Seitz, L C and Brun, Y V},
	month = oct,
	year = {1998},
	pmid = {9748460},
	keywords = {Amdinocillin, Caulobacter crescentus, Mutation, Penicillin Resistance, Penicillins, Phenotype},
	pages = {5235--5239}
}

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