{"_id":"g5KWSwwo67vvkim26","bibbaseid":"sengar-heddi-phan-formationofgquadruplexesinpolygsequencesstructureofapropellertypeparallelstrandedgquadruplexformedbyag15stretch-2014","author_short":["Sengar, A.","Heddi, B.","Phan, A. T."],"bibdata":{"bibtype":"article","type":"article","title":"Formation of G-quadruplexes in poly-G sequences: Structure of a propeller-type parallel-stranded G-quadruplex formed by a G15 stretch.","issn":"1520-4995","url":"http://www.ncbi.nlm.nih.gov/pubmed/25375976","doi":"10.1021/bi500990v","abstract":"Poly-G sequences are found in different genomes including human and have potential to form higher-order structures with various applications. Long poly-G sequences were thought to lead to multiple possible ways of G-quadruplex folding, rendering their structural characterization challenging. Here we investigate the structure of G-quadruplexes formed by poly-G sequences d(TTGnT), where n = 12 to 19. Our data show the presence of multiple and higher-order G-quadruplex structures in most sequences. Strikingly, NMR spectra of the TTG15T sequence containing a stretch of 15 continuous guanines are exceptionally well-resolved and indicate the formation of a well-defined G-quadruplex structure. NMR solution structure of this sequence revealed a propeller-type parallel-stranded G-quadruplex containing three G-tetrad layers and three single-guanine propeller loops. The same structure can potentially form anywhere along a long Gn stretch, making it unique for molecular recognition by other cellular molecules.","journal":"Biochemistry","author":[{"propositions":[],"lastnames":["Sengar"],"firstnames":["Anjali"],"suffixes":[]},{"propositions":[],"lastnames":["Heddi"],"firstnames":["Brahim"],"suffixes":[]},{"propositions":[],"lastnames":["Phan"],"firstnames":["Anh","Tuan"],"suffixes":[]}],"month":"November","year":"2014","pmid":"25375976","keywords":"#nosource","bibtex":"@article{Sengar2014,\n\ttitle = {Formation of {G}-quadruplexes in poly-{G} sequences: {Structure} of a propeller-type parallel-stranded {G}-quadruplex formed by a {G15} stretch.},\n\tissn = {1520-4995},\n\turl = {http://www.ncbi.nlm.nih.gov/pubmed/25375976},\n\tdoi = {10.1021/bi500990v},\n\tabstract = {Poly-G sequences are found in different genomes including human and have potential to form higher-order structures with various applications. Long poly-G sequences were thought to lead to multiple possible ways of G-quadruplex folding, rendering their structural characterization challenging. Here we investigate the structure of G-quadruplexes formed by poly-G sequences d(TTGnT), where n = 12 to 19. Our data show the presence of multiple and higher-order G-quadruplex structures in most sequences. Strikingly, NMR spectra of the TTG15T sequence containing a stretch of 15 continuous guanines are exceptionally well-resolved and indicate the formation of a well-defined G-quadruplex structure. NMR solution structure of this sequence revealed a propeller-type parallel-stranded G-quadruplex containing three G-tetrad layers and three single-guanine propeller loops. The same structure can potentially form anywhere along a long Gn stretch, making it unique for molecular recognition by other cellular molecules.},\n\tjournal = {Biochemistry},\n\tauthor = {Sengar, Anjali and Heddi, Brahim and Phan, Anh Tuan},\n\tmonth = nov,\n\tyear = {2014},\n\tpmid = {25375976},\n\tkeywords = {\\#nosource},\n}\n\n","author_short":["Sengar, A.","Heddi, B.","Phan, A. T."],"key":"Sengar2014","id":"Sengar2014","bibbaseid":"sengar-heddi-phan-formationofgquadruplexesinpolygsequencesstructureofapropellertypeparallelstrandedgquadruplexformedbyag15stretch-2014","role":"author","urls":{"Paper":"http://www.ncbi.nlm.nih.gov/pubmed/25375976"},"keyword":["#nosource"],"metadata":{"authorlinks":{}},"html":""},"bibtype":"article","biburl":"https://bibbase.org/zotero/eric.larG4","dataSources":["4i5C7S78DvJNsaHyg","5L2zM5wNE5CBYNuea"],"keywords":["#nosource"],"search_terms":["formation","quadruplexes","poly","sequences","structure","propeller","type","parallel","stranded","quadruplex","formed","g15","stretch","sengar","heddi","phan"],"title":"Formation of G-quadruplexes in poly-G sequences: Structure of a propeller-type parallel-stranded G-quadruplex formed by a G15 stretch.","year":2014}