@article{Sengar2014,
	title = {Formation of {G}-quadruplexes in poly-{G} sequences: {Structure} of a propeller-type parallel-stranded {G}-quadruplex formed by a {G15} stretch.},
	issn = {1520-4995},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/25375976},
	doi = {10.1021/bi500990v},
	abstract = {Poly-G sequences are found in different genomes including human and have potential to form higher-order structures with various applications. Long poly-G sequences were thought to lead to multiple possible ways of G-quadruplex folding, rendering their structural characterization challenging. Here we investigate the structure of G-quadruplexes formed by poly-G sequences d(TTGnT), where n = 12 to 19. Our data show the presence of multiple and higher-order G-quadruplex structures in most sequences. Strikingly, NMR spectra of the TTG15T sequence containing a stretch of 15 continuous guanines are exceptionally well-resolved and indicate the formation of a well-defined G-quadruplex structure. NMR solution structure of this sequence revealed a propeller-type parallel-stranded G-quadruplex containing three G-tetrad layers and three single-guanine propeller loops. The same structure can potentially form anywhere along a long Gn stretch, making it unique for molecular recognition by other cellular molecules.},
	journal = {Biochemistry},
	author = {Sengar, Anjali and Heddi, Brahim and Phan, Anh Tuan},
	month = nov,
	year = {2014},
	pmid = {25375976},
	keywords = {\#nosource},
}

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