Asthma outcomes improve with continuous positive airway pressure for obstructive sleep apnea. Serrano-Pariente, J., Plaza, V., Soriano, J. B., Mayos, M., López-Viña, A., Picado, C., Vigil, L., & CPASMA Trial Group Allergy, 72(5):802–12, 2017.
doi  abstract   bibtex   
BACKGROUND: Continuous positive airway pressure (CPAP) in asthma patients with concomitant obstructive sleep apnea syndrome (OSAS) seems to have a favorable impact on asthma, but data are inconsistent due to methodological limitations of previous studies. METHODS: Prospective, multicenter study. We examined asthma outcomes after 6 months of CPAP in 99 adult asthma patients (mean age 57 years) with OSAS (respiratory disturbance index ≥20). Asthma control and quality of life were assessed with the Asthma Control Questionnaire (ACQ) and the Mini Asthma Quality of Life Questionnaire (MiniAQLQ), respectively. Data were analyzed by intention-to-treat basis. RESULTS: The mean ± SD score of the ACQ decreased from 1.39 ± 0.91 at baseline to 1.0 ± 0.78 at 6 months (P = 0.003), the percentage of patients with uncontrolled asthma from 41.4% to 17.2% (P = 0.006), and the percentage of patients with asthma attacks in the 6 months before and after treatment from 35.4% to 17.2% (P = 0.015). The score of the mAQLQ increased from 5.12 ± 1.38 to 5.63 ± 1.17 (P = 0.009). There were also significant improvements in symptoms of gastroesophageal reflux and rhinitis, bronchial reversibility, and exhaled nitric oxide values (all P \textless 0.05). No significant changes were observed in drug therapy for asthma or their comorbidities nor in the patients' weight. CONCLUSIONS: Asthma control (both actual and future risk), quality of life, and lung function improved after starting continuous positive airway pressure in asthmatics with moderate to severe obstructive sleep apnea syndrome.
@article{serrano-pariente_asthma_2017,
	title = {Asthma outcomes improve with continuous positive airway pressure for obstructive sleep apnea},
	volume = {72},
	issn = {1398-9995},
	doi = {10.1111/all.13070},
	abstract = {BACKGROUND: Continuous positive airway pressure (CPAP) in asthma patients with concomitant obstructive sleep apnea syndrome (OSAS) seems to have a favorable impact on asthma, but data are inconsistent due to methodological limitations of previous studies.
METHODS: Prospective, multicenter study. We examined asthma outcomes after 6 months of CPAP in 99 adult asthma patients (mean age 57 years) with OSAS (respiratory disturbance index ≥20). Asthma control and quality of life were assessed with the Asthma Control Questionnaire (ACQ) and the Mini Asthma Quality of Life Questionnaire (MiniAQLQ), respectively. Data were analyzed by intention-to-treat basis.
RESULTS: The mean ± SD score of the ACQ decreased from 1.39 ± 0.91 at baseline to 1.0 ± 0.78 at 6 months (P = 0.003), the percentage of patients with uncontrolled asthma from 41.4\% to 17.2\% (P = 0.006), and the percentage of patients with asthma attacks in the 6 months before and after treatment from 35.4\% to 17.2\% (P = 0.015). The score of the mAQLQ increased from 5.12 ± 1.38 to 5.63 ± 1.17 (P = 0.009). There were also significant improvements in symptoms of gastroesophageal reflux and rhinitis, bronchial reversibility, and exhaled nitric oxide values (all P {\textless} 0.05). No significant changes were observed in drug therapy for asthma or their comorbidities nor in the patients' weight.
CONCLUSIONS: Asthma control (both actual and future risk), quality of life, and lung function improved after starting continuous positive airway pressure in asthmatics with moderate to severe obstructive sleep apnea syndrome.},
	language = {ENG},
	number = {5},
	journal = {Allergy},
	author = {Serrano-Pariente, J. and Plaza, V. and Soriano, J. B. and Mayos, M. and López-Viña, A. and Picado, C. and Vigil, L. and {CPASMA Trial Group}},
	year = {2017},
	pmid = {27732758},
	keywords = {Article, Asthma, Continuous positive airway pressure, Quality of Life, acute stroke, bronchial hyperreactivity, obstructive sleep apnea syndrome},
	pages = {802--12},
}

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