Cellular models to study schizophrenia: A systematic review. Seshadri, M., Banerjee, D., Viswanath, B., Ramakrishnan, K., Purushottam, M., Venkatasubramanian, G., & Jain, S. Asian journal of psychiatry, 25:46–53, February, 2017. Place: Netherlandsdoi abstract bibtex BACKGROUND: Advancements in cellular reprogramming techniques have made it possible to directly study brain cells from patients with neuropsychiatric disorders. We have systematically reviewed the applications of induced pluripotent stem cells (IPSCs) and their neural derivatives in understanding the biological basis of schizophrenia. METHOD: We searched the scientific literature published in MEDLINE with the following search strategy: (Pluripotent) AND (Schizophrenia OR Antipsychotic OR Psychosis). Studies written in English that used IPSCs derived from patients with schizophrenia were included. RESULTS: Out of 23 articles, which had used IPSCs from patients with schizophrenia, neurons or neural stem cells had been derived from them in a majority. Several parameters had been studied; the key cellular phenotypes identified included those of synaptic pathology, neural migration/proliferation deficits, and abnormal oxidative phosphorylation. CONCLUSION: Cellular modelling using IPSCs could improve the biological understanding of schizophrenia. Emerging findings are consistent with those of other study designs (post-mortem brain expression, animal studies, genome-wide association, brain imaging). Future studies should focus on refined study designs (family-based, pharmacogenomics, gene editing) and a combination of cellular studies with deep clinical phenotyping.
@article{seshadri_cellular_2017,
title = {Cellular models to study schizophrenia: {A} systematic review.},
volume = {25},
copyright = {Copyright (c) 2016 Elsevier B.V. All rights reserved.},
issn = {1876-2026 1876-2018},
doi = {10.1016/j.ajp.2016.10.015},
abstract = {BACKGROUND: Advancements in cellular reprogramming techniques have made it possible to directly study brain cells from patients with neuropsychiatric disorders. We have systematically reviewed the applications of induced pluripotent stem cells (IPSCs) and their neural derivatives in understanding the biological basis of schizophrenia. METHOD: We searched the scientific literature published in MEDLINE with the following search strategy: (Pluripotent) AND (Schizophrenia OR Antipsychotic OR Psychosis). Studies written in English that used IPSCs derived from patients with schizophrenia were included. RESULTS: Out of 23 articles, which had used IPSCs from patients with schizophrenia, neurons or neural stem cells had been derived from them in a majority. Several parameters had been studied; the key cellular phenotypes identified included those of synaptic pathology, neural migration/proliferation deficits, and abnormal oxidative phosphorylation. CONCLUSION: Cellular modelling using IPSCs could improve the biological understanding of schizophrenia. Emerging findings are consistent with those of other study designs (post-mortem brain expression, animal studies, genome-wide association, brain imaging). Future studies should focus on refined study designs (family-based, pharmacogenomics, gene editing) and a combination of cellular studies with deep clinical phenotyping.},
language = {eng},
journal = {Asian journal of psychiatry},
author = {Seshadri, Manasa and Banerjee, Debanjan and Viswanath, Biju and Ramakrishnan, K. and Purushottam, Meera and Venkatasubramanian, Ganesan and Jain, Sanjeev},
month = feb,
year = {2017},
pmid = {28262173},
note = {Place: Netherlands},
keywords = {*Induced Pluripotent Stem Cells, *Models, Biological, *Schizophrenia, Cell model, Humans, Neuron, Pluripotent, Psychosis, Schizophrenia},
pages = {46--53},
}
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METHOD: We searched the scientific literature published in MEDLINE with the following search strategy: (Pluripotent) AND (Schizophrenia OR Antipsychotic OR Psychosis). Studies written in English that used IPSCs derived from patients with schizophrenia were included. RESULTS: Out of 23 articles, which had used IPSCs from patients with schizophrenia, neurons or neural stem cells had been derived from them in a majority. Several parameters had been studied; the key cellular phenotypes identified included those of synaptic pathology, neural migration/proliferation deficits, and abnormal oxidative phosphorylation. CONCLUSION: Cellular modelling using IPSCs could improve the biological understanding of schizophrenia. Emerging findings are consistent with those of other study designs (post-mortem brain expression, animal studies, genome-wide association, brain imaging). Future studies should focus on refined study designs (family-based, pharmacogenomics, gene editing) and a combination of cellular studies with deep clinical phenotyping.","language":"eng","journal":"Asian journal of psychiatry","author":[{"propositions":[],"lastnames":["Seshadri"],"firstnames":["Manasa"],"suffixes":[]},{"propositions":[],"lastnames":["Banerjee"],"firstnames":["Debanjan"],"suffixes":[]},{"propositions":[],"lastnames":["Viswanath"],"firstnames":["Biju"],"suffixes":[]},{"propositions":[],"lastnames":["Ramakrishnan"],"firstnames":["K."],"suffixes":[]},{"propositions":[],"lastnames":["Purushottam"],"firstnames":["Meera"],"suffixes":[]},{"propositions":[],"lastnames":["Venkatasubramanian"],"firstnames":["Ganesan"],"suffixes":[]},{"propositions":[],"lastnames":["Jain"],"firstnames":["Sanjeev"],"suffixes":[]}],"month":"February","year":"2017","pmid":"28262173","note":"Place: Netherlands","keywords":"*Induced Pluripotent Stem Cells, *Models, Biological, *Schizophrenia, Cell model, Humans, Neuron, Pluripotent, Psychosis, Schizophrenia","pages":"46–53","bibtex":"@article{seshadri_cellular_2017,\n\ttitle = {Cellular models to study schizophrenia: {A} systematic review.},\n\tvolume = {25},\n\tcopyright = {Copyright (c) 2016 Elsevier B.V. All rights reserved.},\n\tissn = {1876-2026 1876-2018},\n\tdoi = {10.1016/j.ajp.2016.10.015},\n\tabstract = {BACKGROUND: Advancements in cellular reprogramming techniques have made it possible to directly study brain cells from patients with neuropsychiatric disorders. We have systematically reviewed the applications of induced pluripotent stem cells (IPSCs) and their neural derivatives in understanding the biological basis of schizophrenia. METHOD: We searched the scientific literature published in MEDLINE with the following search strategy: (Pluripotent) AND (Schizophrenia OR Antipsychotic OR Psychosis). Studies written in English that used IPSCs derived from patients with schizophrenia were included. RESULTS: Out of 23 articles, which had used IPSCs from patients with schizophrenia, neurons or neural stem cells had been derived from them in a majority. Several parameters had been studied; the key cellular phenotypes identified included those of synaptic pathology, neural migration/proliferation deficits, and abnormal oxidative phosphorylation. CONCLUSION: Cellular modelling using IPSCs could improve the biological understanding of schizophrenia. Emerging findings are consistent with those of other study designs (post-mortem brain expression, animal studies, genome-wide association, brain imaging). 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