Protein corona composition of poly(ethylene glycol)- and poly(phosphoester)-coated nanoparticles correlates strongly with the amino acid composition of the protein surface. Settanni, G., Zhou, J., Suo, T., Schöttler, S., Landfester, K., Schmid, F., & Mailänder, V. Nanoscale, 9:2138-2144, The Royal Society of Chemistry, 2017.
Protein corona composition of poly(ethylene glycol)- and poly(phosphoester)-coated nanoparticles correlates strongly with the amino acid composition of the protein surface [link]Paper  doi  abstract   bibtex   
Extensive molecular dynamics simulations reveal that the interactions between proteins and poly(ethylene glycol) (PEG) can be described in terms of the surface composition of the proteins. PEG molecules accumulate around non-polar residues while avoiding the polar ones. A solvent-accessible-surface-area model of protein adsorption accurately fits a large set of data on the composition of the protein corona of poly(ethylene glycol)- and poly(phosphoester)-coated nanoparticles recently obtained by label-free proteomic mass spectrometry.
@article{Settanni2017,
   abstract = {Extensive molecular dynamics simulations reveal that the interactions between proteins and poly(ethylene glycol) (PEG) can be described in terms of the surface composition of the proteins. PEG molecules accumulate around non-polar residues while avoiding the polar ones. A solvent-accessible-surface-area model of protein adsorption accurately fits a large set of data on the composition of the protein corona of poly(ethylene glycol)- and poly(phosphoester)-coated nanoparticles recently obtained by label-free proteomic mass spectrometry.},
   author = {Giovanni Settanni and Jiajia Zhou and Tongchuan Suo and Susanne Schöttler and Katharina Landfester and Friederike Schmid and Volker Mailänder},
   doi = {10.1039/C6NR07022A},
   issn = {20403372},
   issue = {6},
   journal = {Nanoscale},
   pages = {2138-2144},
   publisher = {The Royal Society of Chemistry},
   title = {Protein corona composition of poly(ethylene glycol)- and poly(phosphoester)-coated nanoparticles correlates strongly with the amino acid composition of the protein surface},
   volume = {9},
   url = {http://dx.doi.org/10.1039/C6NR07022A},
   year = {2017},
}

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