@article{
 title = {Four-dimensional realistic modeling of pancreatic organogenesis.},
 type = {article},
 year = {2008},
 identifiers = {[object Object]},
 keywords = {Animals,Body Patterning,Body Patterning: genetics,Bone Morphogenetic Protein 4,Bone Morphogenetic Protein 4: genetics,Computer Simulation,Fibroblast Growth Factor 10,Fibroblast Growth Factor 10: genetics,Intercellular Signaling Peptides and Proteins,Intercellular Signaling Peptides and Proteins: gen,Mice,Models, Biological,Mutation,Organogenesis,Organogenesis: genetics,Pancreas,Pancreas: embryology,Pancreas: growth & development},
 pages = {20374-9},
 volume = {105},
 websites = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2629264&tool=pmcentrez&rendertype=abstract},
 month = {12},
 day = {23},
 id = {17fc014a-923f-351a-a440-b409b3758d5d},
 created = {2016-02-10T15:06:25.000Z},
 file_attached = {true},
 profile_id = {397d75f1-832d-36e0-bbe6-b6878f88c402},
 group_id = {cec5aa9e-65e1-3c21-bc44-78fa6504020e},
 last_modified = {2017-03-14T10:42:46.538Z},
 read = {true},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {Setty2008},
 folder_uuids = {8010415f-2a72-427e-8a93-e658ed2fb621},
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 abstract = {Organogenesis, the process by which organs develop from individual precursor stem cells, requires that the precursor cells proliferate, differentiate, and aggregate to form a functioning structure. This process progresses through changes in 4 dimensions: time and 3 dimensions of space-4D. Experimental analysis of organogenesis, by its nature, cuts the 4D developmental process into static, 2D histological images or into molecular or cellular markers and interactions with little or no spatial dimensionality and minimal dynamics. Understanding organogenesis requires integration of the piecemeal experimental data into a running, realistic and interactive 4D simulation that allows experimentation and hypothesis testing in silico. Here, we describe a fully executable, interactive, visual model for 4D simulation of organogenic development using the mouse pancreas as a representative case. Execution of the model provided a dynamic description of pancreas development, culminating in a structure that remarkably recapitulated morphologic features seen in the embryonic pancreas. In silico mutations in key signaling molecules resulted in altered patterning of the developing pancreas that were in general agreement with in vivo data. The modeling approach described here thus typifies a useful platform for studying organogenesis as a phenomenon in 4 dimensions.},
 bibtype = {article},
 author = {Setty, Yaki and Cohen, Irun R and Dor, Yuval and Harel, David},
 journal = {Proceedings of the National Academy of Sciences of the United States of America},
 number = {51}
}

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This process progresses through changes in 4 dimensions: time and 3 dimensions of space-4D. Experimental analysis of organogenesis, by its nature, cuts the 4D developmental process into static, 2D histological images or into molecular or cellular markers and interactions with little or no spatial dimensionality and minimal dynamics. Understanding organogenesis requires integration of the piecemeal experimental data into a running, realistic and interactive 4D simulation that allows experimentation and hypothesis testing in silico. Here, we describe a fully executable, interactive, visual model for 4D simulation of organogenic development using the mouse pancreas as a representative case. Execution of the model provided a dynamic description of pancreas development, culminating in a structure that remarkably recapitulated morphologic features seen in the embryonic pancreas. 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