Risk Factors of Early Mortality and Morbidity in Esophageal Atresia with Distal Tracheoesophageal Fistula: A Population-Based Cohort Study. Sfeir, R., Rousseau, V., Bonnard, A., Gelas, T., Aumar, M., Panait, N., Piolat, C., Irtan, S., Fouquet, V., Lemandat, A., De Napoli, S., Habonimana, E., Lamireau, T., Lemelle, J. L., El Baz, F., Talon, I., Polimerol, M. L., Allal, H., Buisson, P., Petit, T., Louis, D., Lardy, H., Schmitt, F., Levard, G., Scalabre, A., Michel, J. L., Jaby, O., Pelatan, C., De Vries, P., Borderon, C., Fourcade, L., Breaud, J., Pouzac, M., Tolg, C., Chaussy, Y., Ritz, S. J., Laplace, C., Drumez, E., & Gottrand, F. The Journal of Pediatrics, 234:99–105.e1, July, 2021. ![Risk Factors of Early Mortality and Morbidity in Esophageal Atresia with Distal Tracheoesophageal Fistula: A Population-Based Cohort Study [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex OBJECTIVE: To identify the risk factors for early mortality and morbidity in a population with distal esophageal atresia (EA)-tracheoesophageal fistula. STUDY DESIGN: Cohort study from a national register. Main outcomes and measures included early mortality, hospital length of stay (LoS), need for nutritional support at 1 year of age as a proxy measure of morbidity, and complications during the first year of life. RESULTS: In total, 1008 patients with a lower esophageal fistula were included from January 1, 2008, to December 31, 2014. The survival rate at 3 months was 94.9%. The cumulative hospital LoS was 31.0 (17.0-64.0) days. Multivariate analysis showed that intrahospital mortality at 3 months was associated with low birth weight (OR 0.52, 95% CI [0.38-0.72], P \textless .001), associated cardiac abnormalities (OR 6.09 [1.96-18.89], P = .002), and prenatal diagnosis (OR 2.96 [1.08-8.08], P = .034). LoS was associated with low birth weight (-0.225 ± 0.035, P \textless .001), associated malformations (0.082 ± 0.118, P \textless .001), surgical difficulties (0.270 ± 0.107, P \textless .001), and complications (0.535 ± 0.099, P \textless .001) during the first year of life. Predictive factors for dependency on nutrition support at 1 year of age were complications before 1 year (OR 3.28 [1.23-8.76], P \textless .02) and initial hospital LoS (OR 1.96 [1.15-3.33], P \textless .01). CONCLUSIONS: EA has a low rate of early mortality, but morbidity is high during the first year of life. Identifying factors associated with morbidity may help to improve neonatal care of this population.
@article{sfeir_risk_2021,
title = {Risk {Factors} of {Early} {Mortality} and {Morbidity} in {Esophageal} {Atresia} with {Distal} {Tracheoesophageal} {Fistula}: {A} {Population}-{Based} {Cohort} {Study}},
volume = {234},
issn = {1097-6833},
shorttitle = {Risk {Factors} of {Early} {Mortality} and {Morbidity} in {Esophageal} {Atresia} with {Distal} {Tracheoesophageal} {Fistula}},
url = {http://hdl.handle.net/20.500.12210/40495},
doi = {10.1016/j.jpeds.2021.02.064},
abstract = {OBJECTIVE: To identify the risk factors for early mortality and morbidity in a population with distal esophageal atresia (EA)-tracheoesophageal fistula.
STUDY DESIGN: Cohort study from a national register. Main outcomes and measures included early mortality, hospital length of stay (LoS), need for nutritional support at 1 year of age as a proxy measure of morbidity, and complications during the first year of life.
RESULTS: In total, 1008 patients with a lower esophageal fistula were included from January 1, 2008, to December 31, 2014. The survival rate at 3 months was 94.9\%. The cumulative hospital LoS was 31.0 (17.0-64.0) days. Multivariate analysis showed that intrahospital mortality at 3 months was associated with low birth weight (OR 0.52, 95\% CI [0.38-0.72], P {\textless} .001), associated cardiac abnormalities (OR 6.09 [1.96-18.89], P = .002), and prenatal diagnosis (OR 2.96 [1.08-8.08], P = .034). LoS was associated with low birth weight (-0.225 ± 0.035, P {\textless} .001), associated malformations (0.082 ± 0.118, P {\textless} .001), surgical difficulties (0.270 ± 0.107, P {\textless} .001), and complications (0.535 ± 0.099, P {\textless} .001) during the first year of life. Predictive factors for dependency on nutrition support at 1 year of age were complications before 1 year (OR 3.28 [1.23-8.76], P {\textless} .02) and initial hospital LoS (OR 1.96 [1.15-3.33], P {\textless} .01).
CONCLUSIONS: EA has a low rate of early mortality, but morbidity is high during the first year of life. Identifying factors associated with morbidity may help to improve neonatal care of this population.},
language = {eng},
journal = {The Journal of Pediatrics},
author = {Sfeir, Rony and Rousseau, Veronique and Bonnard, Arnaud and Gelas, Thomas and Aumar, Madeleine and Panait, Nicoleta and Piolat, Christian and Irtan, Sabine and Fouquet, Virginie and Lemandat, Aurelie and De Napoli, Stephan and Habonimana, Edouard and Lamireau, Thierry and Lemelle, Jean Louis and El Baz, Frederic and Talon, Isabelle and Polimerol, Marie Laurence and Allal, Hussein and Buisson, Philippe and Petit, Thierry and Louis, David and Lardy, Hubert and Schmitt, Francoise and Levard, Guillaume and Scalabre, Aurélien and Michel, Jean Luc and Jaby, Olivier and Pelatan, Cecile and De Vries, Philine and Borderon, Corinne and Fourcade, Laurent and Breaud, Jean and Pouzac, Myriam and Tolg, Cecilia and Chaussy, Yann and Ritz, Sandy Jochault and Laplace, Christophe and Drumez, Elodie and Gottrand, Frederic},
month = jul,
year = {2021},
pmid = {33667507},
keywords = {Esophageal Atresia, Female, France, Heart Defects, Congenital, Humans, Infant, Infant, Low Birth Weight, Infant, Newborn, Length of Stay, Male, Nutritional Support, Prenatal Diagnosis, Registries, Risk Factors, Surveys and Questionnaires, Tracheoesophageal Fistula, congenital abnormalities, population-based registry, prenatal diagnosis},
pages = {99--105.e1},
}
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{"_id":"8oWg9a2Cju5RqcPyd","bibbaseid":"sfeir-rousseau-bonnard-gelas-aumar-panait-piolat-irtan-etal-riskfactorsofearlymortalityandmorbidityinesophagealatresiawithdistaltracheoesophagealfistulaapopulationbasedcohortstudy-2021","author_short":["Sfeir, R.","Rousseau, V.","Bonnard, A.","Gelas, T.","Aumar, M.","Panait, N.","Piolat, C.","Irtan, S.","Fouquet, V.","Lemandat, A.","De Napoli, S.","Habonimana, E.","Lamireau, T.","Lemelle, J. L.","El Baz, F.","Talon, I.","Polimerol, M. L.","Allal, H.","Buisson, P.","Petit, T.","Louis, D.","Lardy, H.","Schmitt, F.","Levard, G.","Scalabre, A.","Michel, J. L.","Jaby, O.","Pelatan, C.","De Vries, P.","Borderon, C.","Fourcade, L.","Breaud, J.","Pouzac, M.","Tolg, C.","Chaussy, Y.","Ritz, S. J.","Laplace, C.","Drumez, E.","Gottrand, F."],"bibdata":{"bibtype":"article","type":"article","title":"Risk Factors of Early Mortality and Morbidity in Esophageal Atresia with Distal Tracheoesophageal Fistula: A Population-Based Cohort Study","volume":"234","issn":"1097-6833","shorttitle":"Risk Factors of Early Mortality and Morbidity in Esophageal Atresia with Distal Tracheoesophageal Fistula","url":"http://hdl.handle.net/20.500.12210/40495","doi":"10.1016/j.jpeds.2021.02.064","abstract":"OBJECTIVE: To identify the risk factors for early mortality and morbidity in a population with distal esophageal atresia (EA)-tracheoesophageal fistula. STUDY DESIGN: Cohort study from a national register. Main outcomes and measures included early mortality, hospital length of stay (LoS), need for nutritional support at 1 year of age as a proxy measure of morbidity, and complications during the first year of life. RESULTS: In total, 1008 patients with a lower esophageal fistula were included from January 1, 2008, to December 31, 2014. The survival rate at 3 months was 94.9%. The cumulative hospital LoS was 31.0 (17.0-64.0) days. Multivariate analysis showed that intrahospital mortality at 3 months was associated with low birth weight (OR 0.52, 95% CI [0.38-0.72], P \\textless .001), associated cardiac abnormalities (OR 6.09 [1.96-18.89], P = .002), and prenatal diagnosis (OR 2.96 [1.08-8.08], P = .034). LoS was associated with low birth weight (-0.225 ± 0.035, P \\textless .001), associated malformations (0.082 ± 0.118, P \\textless .001), surgical difficulties (0.270 ± 0.107, P \\textless .001), and complications (0.535 ± 0.099, P \\textless .001) during the first year of life. Predictive factors for dependency on nutrition support at 1 year of age were complications before 1 year (OR 3.28 [1.23-8.76], P \\textless .02) and initial hospital LoS (OR 1.96 [1.15-3.33], P \\textless .01). CONCLUSIONS: EA has a low rate of early mortality, but morbidity is high during the first year of life. Identifying factors associated with morbidity may help to improve neonatal care of this population.","language":"eng","journal":"The Journal of Pediatrics","author":[{"propositions":[],"lastnames":["Sfeir"],"firstnames":["Rony"],"suffixes":[]},{"propositions":[],"lastnames":["Rousseau"],"firstnames":["Veronique"],"suffixes":[]},{"propositions":[],"lastnames":["Bonnard"],"firstnames":["Arnaud"],"suffixes":[]},{"propositions":[],"lastnames":["Gelas"],"firstnames":["Thomas"],"suffixes":[]},{"propositions":[],"lastnames":["Aumar"],"firstnames":["Madeleine"],"suffixes":[]},{"propositions":[],"lastnames":["Panait"],"firstnames":["Nicoleta"],"suffixes":[]},{"propositions":[],"lastnames":["Piolat"],"firstnames":["Christian"],"suffixes":[]},{"propositions":[],"lastnames":["Irtan"],"firstnames":["Sabine"],"suffixes":[]},{"propositions":[],"lastnames":["Fouquet"],"firstnames":["Virginie"],"suffixes":[]},{"propositions":[],"lastnames":["Lemandat"],"firstnames":["Aurelie"],"suffixes":[]},{"propositions":[],"lastnames":["De","Napoli"],"firstnames":["Stephan"],"suffixes":[]},{"propositions":[],"lastnames":["Habonimana"],"firstnames":["Edouard"],"suffixes":[]},{"propositions":[],"lastnames":["Lamireau"],"firstnames":["Thierry"],"suffixes":[]},{"propositions":[],"lastnames":["Lemelle"],"firstnames":["Jean","Louis"],"suffixes":[]},{"propositions":[],"lastnames":["El","Baz"],"firstnames":["Frederic"],"suffixes":[]},{"propositions":[],"lastnames":["Talon"],"firstnames":["Isabelle"],"suffixes":[]},{"propositions":[],"lastnames":["Polimerol"],"firstnames":["Marie","Laurence"],"suffixes":[]},{"propositions":[],"lastnames":["Allal"],"firstnames":["Hussein"],"suffixes":[]},{"propositions":[],"lastnames":["Buisson"],"firstnames":["Philippe"],"suffixes":[]},{"propositions":[],"lastnames":["Petit"],"firstnames":["Thierry"],"suffixes":[]},{"propositions":[],"lastnames":["Louis"],"firstnames":["David"],"suffixes":[]},{"propositions":[],"lastnames":["Lardy"],"firstnames":["Hubert"],"suffixes":[]},{"propositions":[],"lastnames":["Schmitt"],"firstnames":["Francoise"],"suffixes":[]},{"propositions":[],"lastnames":["Levard"],"firstnames":["Guillaume"],"suffixes":[]},{"propositions":[],"lastnames":["Scalabre"],"firstnames":["Aurélien"],"suffixes":[]},{"propositions":[],"lastnames":["Michel"],"firstnames":["Jean","Luc"],"suffixes":[]},{"propositions":[],"lastnames":["Jaby"],"firstnames":["Olivier"],"suffixes":[]},{"propositions":[],"lastnames":["Pelatan"],"firstnames":["Cecile"],"suffixes":[]},{"propositions":[],"lastnames":["De","Vries"],"firstnames":["Philine"],"suffixes":[]},{"propositions":[],"lastnames":["Borderon"],"firstnames":["Corinne"],"suffixes":[]},{"propositions":[],"lastnames":["Fourcade"],"firstnames":["Laurent"],"suffixes":[]},{"propositions":[],"lastnames":["Breaud"],"firstnames":["Jean"],"suffixes":[]},{"propositions":[],"lastnames":["Pouzac"],"firstnames":["Myriam"],"suffixes":[]},{"propositions":[],"lastnames":["Tolg"],"firstnames":["Cecilia"],"suffixes":[]},{"propositions":[],"lastnames":["Chaussy"],"firstnames":["Yann"],"suffixes":[]},{"propositions":[],"lastnames":["Ritz"],"firstnames":["Sandy","Jochault"],"suffixes":[]},{"propositions":[],"lastnames":["Laplace"],"firstnames":["Christophe"],"suffixes":[]},{"propositions":[],"lastnames":["Drumez"],"firstnames":["Elodie"],"suffixes":[]},{"propositions":[],"lastnames":["Gottrand"],"firstnames":["Frederic"],"suffixes":[]}],"month":"July","year":"2021","pmid":"33667507","keywords":"Esophageal Atresia, Female, France, Heart Defects, Congenital, Humans, Infant, Infant, Low Birth Weight, Infant, Newborn, Length of Stay, Male, Nutritional Support, Prenatal Diagnosis, Registries, Risk Factors, Surveys and Questionnaires, Tracheoesophageal Fistula, congenital abnormalities, population-based registry, prenatal diagnosis","pages":"99–105.e1","bibtex":"@article{sfeir_risk_2021,\n\ttitle = {Risk {Factors} of {Early} {Mortality} and {Morbidity} in {Esophageal} {Atresia} with {Distal} {Tracheoesophageal} {Fistula}: {A} {Population}-{Based} {Cohort} {Study}},\n\tvolume = {234},\n\tissn = {1097-6833},\n\tshorttitle = {Risk {Factors} of {Early} {Mortality} and {Morbidity} in {Esophageal} {Atresia} with {Distal} {Tracheoesophageal} {Fistula}},\n\turl = {http://hdl.handle.net/20.500.12210/40495},\n\tdoi = {10.1016/j.jpeds.2021.02.064},\n\tabstract = {OBJECTIVE: To identify the risk factors for early mortality and morbidity in a population with distal esophageal atresia (EA)-tracheoesophageal fistula.\nSTUDY DESIGN: Cohort study from a national register. Main outcomes and measures included early mortality, hospital length of stay (LoS), need for nutritional support at 1 year of age as a proxy measure of morbidity, and complications during the first year of life.\nRESULTS: In total, 1008 patients with a lower esophageal fistula were included from January 1, 2008, to December 31, 2014. The survival rate at 3 months was 94.9\\%. The cumulative hospital LoS was 31.0 (17.0-64.0) days. Multivariate analysis showed that intrahospital mortality at 3 months was associated with low birth weight (OR 0.52, 95\\% CI [0.38-0.72], P {\\textless} .001), associated cardiac abnormalities (OR 6.09 [1.96-18.89], P = .002), and prenatal diagnosis (OR 2.96 [1.08-8.08], P = .034). LoS was associated with low birth weight (-0.225 ± 0.035, P {\\textless} .001), associated malformations (0.082 ± 0.118, P {\\textless} .001), surgical difficulties (0.270 ± 0.107, P {\\textless} .001), and complications (0.535 ± 0.099, P {\\textless} .001) during the first year of life. Predictive factors for dependency on nutrition support at 1 year of age were complications before 1 year (OR 3.28 [1.23-8.76], P {\\textless} .02) and initial hospital LoS (OR 1.96 [1.15-3.33], P {\\textless} .01).\nCONCLUSIONS: EA has a low rate of early mortality, but morbidity is high during the first year of life. Identifying factors associated with morbidity may help to improve neonatal care of this population.},\n\tlanguage = {eng},\n\tjournal = {The Journal of Pediatrics},\n\tauthor = {Sfeir, Rony and Rousseau, Veronique and Bonnard, Arnaud and Gelas, Thomas and Aumar, Madeleine and Panait, Nicoleta and Piolat, Christian and Irtan, Sabine and Fouquet, Virginie and Lemandat, Aurelie and De Napoli, Stephan and Habonimana, Edouard and Lamireau, Thierry and Lemelle, Jean Louis and El Baz, Frederic and Talon, Isabelle and Polimerol, Marie Laurence and Allal, Hussein and Buisson, Philippe and Petit, Thierry and Louis, David and Lardy, Hubert and Schmitt, Francoise and Levard, Guillaume and Scalabre, Aurélien and Michel, Jean Luc and Jaby, Olivier and Pelatan, Cecile and De Vries, Philine and Borderon, Corinne and Fourcade, Laurent and Breaud, Jean and Pouzac, Myriam and Tolg, Cecilia and Chaussy, Yann and Ritz, Sandy Jochault and Laplace, Christophe and Drumez, Elodie and Gottrand, Frederic},\n\tmonth = jul,\n\tyear = {2021},\n\tpmid = {33667507},\n\tkeywords = {Esophageal Atresia, Female, France, Heart Defects, Congenital, Humans, Infant, Infant, Low Birth Weight, Infant, Newborn, Length of Stay, Male, Nutritional Support, Prenatal Diagnosis, Registries, Risk Factors, Surveys and Questionnaires, Tracheoesophageal Fistula, congenital abnormalities, population-based registry, prenatal diagnosis},\n\tpages = {99--105.e1},\n}\n\n\n\n","author_short":["Sfeir, R.","Rousseau, V.","Bonnard, A.","Gelas, T.","Aumar, M.","Panait, N.","Piolat, C.","Irtan, S.","Fouquet, V.","Lemandat, A.","De Napoli, S.","Habonimana, E.","Lamireau, T.","Lemelle, J. L.","El Baz, F.","Talon, I.","Polimerol, M. L.","Allal, H.","Buisson, P.","Petit, T.","Louis, D.","Lardy, H.","Schmitt, F.","Levard, G.","Scalabre, A.","Michel, J. L.","Jaby, O.","Pelatan, C.","De Vries, P.","Borderon, C.","Fourcade, L.","Breaud, J.","Pouzac, M.","Tolg, C.","Chaussy, Y.","Ritz, S. J.","Laplace, C.","Drumez, E.","Gottrand, F."],"key":"sfeir_risk_2021","id":"sfeir_risk_2021","bibbaseid":"sfeir-rousseau-bonnard-gelas-aumar-panait-piolat-irtan-etal-riskfactorsofearlymortalityandmorbidityinesophagealatresiawithdistaltracheoesophagealfistulaapopulationbasedcohortstudy-2021","role":"author","urls":{"Paper":"http://hdl.handle.net/20.500.12210/40495"},"keyword":["Esophageal Atresia","Female","France","Heart Defects","Congenital","Humans","Infant","Infant","Low Birth Weight","Infant","Newborn","Length of Stay","Male","Nutritional Support","Prenatal Diagnosis","Registries","Risk Factors","Surveys and Questionnaires","Tracheoesophageal Fistula","congenital abnormalities","population-based registry","prenatal diagnosis"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/zotero-group/Leromela/5632740","dataSources":["xEepG2Bu5H8yCXNLe","9KDMJQgGj9aC6ujCM","tJu2LQsng3WaoKpcL"],"keywords":["esophageal atresia","female","france","heart defects","congenital","humans","infant","infant","low birth weight","infant","newborn","length of stay","male","nutritional support","prenatal diagnosis","registries","risk factors","surveys and questionnaires","tracheoesophageal fistula","congenital abnormalities","population-based registry","prenatal diagnosis"],"search_terms":["risk","factors","early","mortality","morbidity","esophageal","atresia","distal","tracheoesophageal","fistula","population","based","cohort","study","sfeir","rousseau","bonnard","gelas","aumar","panait","piolat","irtan","fouquet","lemandat","de napoli","habonimana","lamireau","lemelle","el baz","talon","polimerol","allal","buisson","petit","louis","lardy","schmitt","levard","scalabre","michel","jaby","pelatan","de vries","borderon","fourcade","breaud","pouzac","tolg","chaussy","ritz","laplace","drumez","gottrand"],"title":"Risk Factors of Early Mortality and Morbidity in Esophageal Atresia with Distal Tracheoesophageal Fistula: A Population-Based Cohort Study","year":2021}