@article{
 title = {An ion funnel interface for improved ion focusing and sensitivity using electrospray ionization mass spectrometry.},
 type = {article},
 year = {1998},
 identifiers = {[object Object]},
 keywords = {Animals,Cattle,Cytochrome c Group,Cytochrome c Group: analysis,Erythrocytes,Erythrocytes: metabolism,Gramicidin,Gramicidin: analysis,Horses,Myocardium,Myocardium: metabolism,Myoglobin,Myoglobin: analysis,Reproducibility of Results,Spectrometry, Mass, Secondary Ion,Spectrometry, Mass, Secondary Ion: instrumentation,Spectrometry, Mass, Secondary Ion: methods,Ubiquitins,Ubiquitins: analysis},
 pages = {4111-9},
 volume = {70},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/9784749},
 month = {10},
 day = {1},
 id = {cfe7ff88-f3f7-3ee0-a6a5-2d2dc1376574},
 created = {2014-11-13T17:56:03.000Z},
 file_attached = {true},
 profile_id = {5a758209-74fb-3a9c-b322-2ae7f22f7b6c},
 group_id = {63e349d6-2c70-3938-9e67-2f6483f6cbab},
 last_modified = {2014-11-18T21:16:45.000Z},
 read = {true},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 abstract = {To improve upon the already impressive sensitivity achievable with electrospray ionization sources, a novel electrohydrodynamic ion funnel interface has been developed and implemented with a triple-quadrupole mass spectrometer. The ion funnel interface effectively consists of a series of ring electrodes of increasingly small internal diameters to which rf and dc electric potentials are coapplied. In the 1-10-Torr pressure range, the electric fields cause the collisionally damped ions to be more effectively focused and transmitted as a collimated ion beam. This paper describes the ion funnel design and presents an evaluation of its performance using a triple-quadrupole mass spectrometer. Ion transmission and m/z discriminating parameters (resulting in both effective low- and high-m/z cutoffs) are presented based upon both ion current measurements and mass spectra. Electrospray ionization mass spectra of selected protein solutions demonstrated well over 1 order of magnitude increase in signal relative to that of the instrument operated in its standard (inlet capillary-skimmer) configuration under similar conditions. The present results suggest that it will be feasible to realize close to 100% ion transmission efficiency for analytically relevant ions through the electrospray ionization interface and into the mass analyzer.},
 bibtype = {article},
 author = {Shaffer, S a and Prior, D C and Anderson, G a and Udseth, H R and Smith, R D},
 journal = {Analytical chemistry},
 number = {19}
}

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