Transmission of Extensively Drug-Resistant Tuberculosis in South Africa. Shah, N. S., Auld, S. C., Brust, J. C., Mathema, B., Ismail, N., Moodley, P., Mlisana, K., Allana, S., Campbell, A., Mthiyane, T., Morris, N., Mpangase, P., van der Meulen, H., Omar, S. V., Brown, T. S., Narechania, A., Shaskina, E., Kapwata, T., Kreiswirth, B., & Gandhi, N. R. New England Journal of Medicine, 376(3):243–253, January, 2017. 00047![Transmission of Extensively Drug-Resistant Tuberculosis in South Africa [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Drug-resistant tuberculosis threatens recent gains in the treatment of tuberculosis and human immunodeficiency virus (HIV) infection worldwide. A widespread epidemic of extensively drug-resistant (XDR) tuberculosis is occurring in South Africa, where cases have increased substantially since 2002. The factors driving this rapid increase have not been fully elucidated, but such knowledge is needed to guide public health interventions. The majority of cases of XDR tuberculosis in KwaZulu-Natal, South Africa, an area with a high tuberculosis burden, were probably due to transmission rather than to inadequate treatment of MDR tuberculosis. These data suggest that control of the epidemic of drug-resistant tuberculosis requires an increased focus on interrupting transmission. (Funded by the National Institute of Allergy and Infectious Diseases and others.)
@article{shah_transmission_2017,
title = {Transmission of {Extensively} {Drug}-{Resistant} {Tuberculosis} in {South} {Africa}},
volume = {376},
issn = {0028-4793, 1533-4406},
url = {http://www.nejm.org/doi/10.1056/NEJMoa1604544},
doi = {10.1056/NEJMoa1604544},
abstract = {Drug-resistant tuberculosis threatens recent gains in the treatment of tuberculosis and human immunodeficiency virus (HIV) infection worldwide. A widespread epidemic of extensively drug-resistant (XDR) tuberculosis is occurring in South Africa, where cases have increased substantially since 2002. The factors driving this rapid increase have not been fully elucidated, but such knowledge is needed to guide public health interventions.
The majority of cases of XDR tuberculosis in KwaZulu-Natal, South Africa, an area with a high tuberculosis burden, were probably due to transmission rather than to inadequate treatment of MDR tuberculosis. These data suggest that control of the epidemic of drug-resistant tuberculosis requires an increased focus on interrupting transmission. (Funded by the National Institute of Allergy and Infectious Diseases and others.)},
language = {en},
number = {3},
urldate = {2017-01-21},
journal = {New England Journal of Medicine},
author = {Shah, N. Sarita and Auld, Sara C. and Brust, James C.M. and Mathema, Barun and Ismail, Nazir and Moodley, Pravi and Mlisana, Koleka and Allana, Salim and Campbell, Angela and Mthiyane, Thuli and Morris, Natashia and Mpangase, Primrose and van der Meulen, Hermina and Omar, Shaheed V. and Brown, Tyler S. and Narechania, Apurva and Shaskina, Elena and Kapwata, Thandi and Kreiswirth, Barry and Gandhi, Neel R.},
month = jan,
year = {2017},
note = {00047},
keywords = {collapse, health-epidemics-pandemics},
pages = {243--253},
file = {Shah et al. - 2017 - Transmission of Extensively Drug-Resistant Tubercu.pdf:C\:\\Users\\rsrs\\Documents\\Zotero Database\\storage\\NFUFNTCK\\Shah et al. - 2017 - Transmission of Extensively Drug-Resistant Tubercu.pdf:application/pdf}
}
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A widespread epidemic of extensively drug-resistant (XDR) tuberculosis is occurring in South Africa, where cases have increased substantially since 2002. The factors driving this rapid increase have not been fully elucidated, but such knowledge is needed to guide public health interventions. The majority of cases of XDR tuberculosis in KwaZulu-Natal, South Africa, an area with a high tuberculosis burden, were probably due to transmission rather than to inadequate treatment of MDR tuberculosis. These data suggest that control of the epidemic of drug-resistant tuberculosis requires an increased focus on interrupting transmission. 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