Altered miRNA expression patterns in Tff2 knock-out mice correlate with cellular pathways of neoplastic development and caloric metabolism. Shah, A. A., Leidinger, P., Keller, A., Wendschlag, A., Meese, E., & Blin, N. International journal of molecular medicine, 29:637–643, April, 2012. doi abstract bibtex The trefoil peptide family, consisting in mammals of three members namely TFF1, 2 and 3, plays a cytoprotective role in epithelial cells of various tissues, mainly in the digestive tract. Tff1, Tff2 or Tff3 knock-out mouse models developed various kinds of gastrointestinal impairment. microRNAs are known to be novel gene regulators. We aimed to investigate the physiological role of such miRNAs in Tff2 knock-out mice. Whole miRNome profiling and in silico analysis were performed for Tff2-KO and WT mice. Our latest data explored the role of miRNAs in the regulatory cascades and molecular processes of Tff2-/- mice. As much as 6% of the Tff2-KO mice miRNome was significantly dys-regulated. Further in silico analysis suggests that the respective dys-regulated part of the miRNome is involved in human pathological processes, including pancreatic, colorectal and basal cell cancer. Additionally, the dys-regulated miRNome targets pathways involved in carbohydrate metabolism and adipocytokine signaling. The latter links deficient caloric maintenance in Tff2 and previous observation in Tff3-KO mice with miRNAs. In summary, our proof-of-concept study indicates that miRNAs may play an important role in the regulatory processes of the trefoil peptide family, especially in the regulation of cancer-related cascades.
@Article{Shah2012,
author = {Shah, Aftab Ali and Leidinger, Petra and Keller, Andreas and Wendschlag, Anke and Meese, Eckart and Blin, Nikolaus},
title = {Altered miRNA expression patterns in Tff2 knock-out mice correlate with cellular pathways of neoplastic development and caloric metabolism.},
journal = {International journal of molecular medicine},
year = {2012},
volume = {29},
pages = {637--643},
month = apr,
issn = {1791-244X},
abstract = {The trefoil peptide family, consisting in mammals of three members namely TFF1, 2 and 3, plays a cytoprotective role in epithelial cells of various tissues, mainly in the digestive tract. Tff1, Tff2 or Tff3 knock-out mouse models developed various kinds of gastrointestinal impairment. microRNAs are known to be novel gene regulators. We aimed to investigate the physiological role of such miRNAs in Tff2 knock-out mice. Whole miRNome profiling and in silico analysis were performed for Tff2-KO and WT mice. Our latest data explored the role of miRNAs in the regulatory cascades and molecular processes of Tff2-/- mice. As much as 6% of the Tff2-KO mice miRNome was significantly dys-regulated. Further in silico analysis suggests that the respective dys-regulated part of the miRNome is involved in human pathological processes, including pancreatic, colorectal and basal cell cancer. Additionally, the dys-regulated miRNome targets pathways involved in carbohydrate metabolism and adipocytokine signaling. The latter links deficient caloric maintenance in Tff2 and previous observation in Tff3-KO mice with miRNAs. In summary, our proof-of-concept study indicates that miRNAs may play an important role in the regulatory processes of the trefoil peptide family, especially in the regulation of cancer-related cascades.},
chemicals = {Adipokines, MicroRNAs, Mucins, Muscle Proteins, Peptides, TFF2 protein, human, TFF2 protein, mouse, Trefoil Factor-2},
citation-subset = {IM},
completed = {2012-05-29},
country = {Greece},
doi = {10.3892/ijmm.2012.881},
issn-linking = {1107-3756},
issue = {4},
keywords = {Adipokines, genetics, metabolism; Animals; Carbohydrate Metabolism, genetics; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genes, Regulator; Mice; Mice, Knockout; MicroRNAs, genetics, metabolism; Mucins, genetics, metabolism; Muscle Proteins, genetics, metabolism; Peptides, genetics, metabolism; Signal Transduction; Trefoil Factor-2},
nlm-id = {9810955},
owner = {NLM},
pmc = {PMC3573770},
pmid = {22245972},
pubmodel = {Print-Electronic},
pubstatus = {ppublish},
revised = {2016-11-25},
}
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A.","Leidinger, P.","Keller, A.","Wendschlag, A.","Meese, E.","Blin, N."],"year":2012,"bibtype":"article","biburl":"https://www.ccb.uni-saarland.de/wp-content/uploads/2024/01/references.bib_.txt","bibdata":{"bibtype":"article","type":"article","author":[{"propositions":[],"lastnames":["Shah"],"firstnames":["Aftab","Ali"],"suffixes":[]},{"propositions":[],"lastnames":["Leidinger"],"firstnames":["Petra"],"suffixes":[]},{"propositions":[],"lastnames":["Keller"],"firstnames":["Andreas"],"suffixes":[]},{"propositions":[],"lastnames":["Wendschlag"],"firstnames":["Anke"],"suffixes":[]},{"propositions":[],"lastnames":["Meese"],"firstnames":["Eckart"],"suffixes":[]},{"propositions":[],"lastnames":["Blin"],"firstnames":["Nikolaus"],"suffixes":[]}],"title":"Altered miRNA expression patterns in Tff2 knock-out mice correlate with cellular pathways of neoplastic development and caloric metabolism.","journal":"International journal of molecular medicine","year":"2012","volume":"29","pages":"637–643","month":"April","issn":"1791-244X","abstract":"The trefoil peptide family, consisting in mammals of three members namely TFF1, 2 and 3, plays a cytoprotective role in epithelial cells of various tissues, mainly in the digestive tract. Tff1, Tff2 or Tff3 knock-out mouse models developed various kinds of gastrointestinal impairment. microRNAs are known to be novel gene regulators. We aimed to investigate the physiological role of such miRNAs in Tff2 knock-out mice. Whole miRNome profiling and in silico analysis were performed for Tff2-KO and WT mice. Our latest data explored the role of miRNAs in the regulatory cascades and molecular processes of Tff2-/- mice. As much as 6% of the Tff2-KO mice miRNome was significantly dys-regulated. Further in silico analysis suggests that the respective dys-regulated part of the miRNome is involved in human pathological processes, including pancreatic, colorectal and basal cell cancer. Additionally, the dys-regulated miRNome targets pathways involved in carbohydrate metabolism and adipocytokine signaling. The latter links deficient caloric maintenance in Tff2 and previous observation in Tff3-KO mice with miRNAs. 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