@article{shankarappa_effect_2017,
	title = {Effect of {CLU} and {PICALM} polymorphisms on {AD} risk: {A} study from south {India}.},
	volume = {27},
	copyright = {Copyright (c) 2016. Published by Elsevier B.V.},
	issn = {1876-2026 1876-2018},
	doi = {10.1016/j.ajp.2016.12.017},
	abstract = {OBJECTIVES: To study the association of apolipoprotein E (APOE), Clusterin (CLU) and phosphatidylinositol binding clathrin assembly protein (PICALM) polymorphisms in Alzheimer's disease (AD) subjects compared to cognitively normal control subjects in an Indian population. METHODS: The study subjects included persons with AD (N=243) and age group matched healthy controls (N=164). All the AD subjects were evaluated using a standard protocol. DNA was isolated from whole blood. APOE (rs7412, rs429358), CLU (rs11136000) and PICALM (rs3851179) were genotyped. General linear model was used to test the association between the individual risk genotypes and AD. RESULTS: The presence of APOE epsilon4 was associated with AD after adjusting for age and gender (p{\textless}0.0001). There was no association observed with AD at both rs11136000 CLU (p=0.25) and rs3851179 PICALM (p=0.54). CONCLUSION: Our results confirmed a significant association of APOE epsilon4 carrier status with AD. No association was observed for CLU and PICALM with AD. This might be due to a different genetic background. There are no previous reports of these polymorphisms in an Indian cohort. Future Indian AD studies should investigate additional SNPs in a larger sample size in these genes.},
	language = {eng},
	journal = {Asian journal of psychiatry},
	author = {Shankarappa, Bhagyalakshmi Mallapura and Kota, Lakshmi Narayanan and Purushottam, Meera and Nagpal, Kavita and Mukherjee, Odity and Viswanath, Biju and Varghese, Mathew and Bharath, Srikala and Jain, Sanjeev},
	month = jun,
	year = {2017},
	pmid = {28558900},
	note = {Place: Netherlands},
	keywords = {Aged, Alzheimer Disease/*genetics, Apolipoprotein E4/genetics, Clusterin/*genetics, Female, Humans, India, Male, Middle Aged, Monomeric Clathrin Assembly Proteins/*genetics, Polymorphism, Single Nucleotide, Risk},
	pages = {7--11},
}

{"_id":"EaydxbMaoYHz5pKNC","bibbaseid":"shankarappa-kota-purushottam-nagpal-mukherjee-viswanath-varghese-bharath-etal-effectofcluandpicalmpolymorphismsonadriskastudyfromsouthindia-2017","author_short":["Shankarappa, B. M.","Kota, L. N.","Purushottam, M.","Nagpal, K.","Mukherjee, O.","Viswanath, B.","Varghese, M.","Bharath, S.","Jain, S."],"bibdata":{"bibtype":"article","type":"article","title":"Effect of CLU and PICALM polymorphisms on AD risk: A study from south India.","volume":"27","copyright":"Copyright (c) 2016. Published by Elsevier B.V.","issn":"1876-2026 1876-2018","doi":"10.1016/j.ajp.2016.12.017","abstract":"OBJECTIVES: To study the association of apolipoprotein E (APOE), Clusterin (CLU) and phosphatidylinositol binding clathrin assembly protein (PICALM) polymorphisms in Alzheimer's disease (AD) subjects compared to cognitively normal control subjects in an Indian population. METHODS: The study subjects included persons with AD (N=243) and age group matched healthy controls (N=164). All the AD subjects were evaluated using a standard protocol. DNA was isolated from whole blood. APOE (rs7412, rs429358), CLU (rs11136000) and PICALM (rs3851179) were genotyped. General linear model was used to test the association between the individual risk genotypes and AD. RESULTS: The presence of APOE epsilon4 was associated with AD after adjusting for age and gender (p\\textless0.0001). There was no association observed with AD at both rs11136000 CLU (p=0.25) and rs3851179 PICALM (p=0.54). CONCLUSION: Our results confirmed a significant association of APOE epsilon4 carrier status with AD. No association was observed for CLU and PICALM with AD. This might be due to a different genetic background. There are no previous reports of these polymorphisms in an Indian cohort. Future Indian AD studies should investigate additional SNPs in a larger sample size in these genes.","language":"eng","journal":"Asian journal of psychiatry","author":[{"propositions":[],"lastnames":["Shankarappa"],"firstnames":["Bhagyalakshmi","Mallapura"],"suffixes":[]},{"propositions":[],"lastnames":["Kota"],"firstnames":["Lakshmi","Narayanan"],"suffixes":[]},{"propositions":[],"lastnames":["Purushottam"],"firstnames":["Meera"],"suffixes":[]},{"propositions":[],"lastnames":["Nagpal"],"firstnames":["Kavita"],"suffixes":[]},{"propositions":[],"lastnames":["Mukherjee"],"firstnames":["Odity"],"suffixes":[]},{"propositions":[],"lastnames":["Viswanath"],"firstnames":["Biju"],"suffixes":[]},{"propositions":[],"lastnames":["Varghese"],"firstnames":["Mathew"],"suffixes":[]},{"propositions":[],"lastnames":["Bharath"],"firstnames":["Srikala"],"suffixes":[]},{"propositions":[],"lastnames":["Jain"],"firstnames":["Sanjeev"],"suffixes":[]}],"month":"June","year":"2017","pmid":"28558900","note":"Place: Netherlands","keywords":"Aged, Alzheimer Disease/*genetics, Apolipoprotein E4/genetics, Clusterin/*genetics, Female, Humans, India, Male, Middle Aged, Monomeric Clathrin Assembly Proteins/*genetics, Polymorphism, Single Nucleotide, Risk","pages":"7–11","bibtex":"@article{shankarappa_effect_2017,\n\ttitle = {Effect of {CLU} and {PICALM} polymorphisms on {AD} risk: {A} study from south {India}.},\n\tvolume = {27},\n\tcopyright = {Copyright (c) 2016. Published by Elsevier B.V.},\n\tissn = {1876-2026 1876-2018},\n\tdoi = {10.1016/j.ajp.2016.12.017},\n\tabstract = {OBJECTIVES: To study the association of apolipoprotein E (APOE), Clusterin (CLU) and phosphatidylinositol binding clathrin assembly protein (PICALM) polymorphisms in Alzheimer's disease (AD) subjects compared to cognitively normal control subjects in an Indian population. METHODS: The study subjects included persons with AD (N=243) and age group matched healthy controls (N=164). All the AD subjects were evaluated using a standard protocol. DNA was isolated from whole blood. APOE (rs7412, rs429358), CLU (rs11136000) and PICALM (rs3851179) were genotyped. General linear model was used to test the association between the individual risk genotypes and AD. RESULTS: The presence of APOE epsilon4 was associated with AD after adjusting for age and gender (p{\\textless}0.0001). There was no association observed with AD at both rs11136000 CLU (p=0.25) and rs3851179 PICALM (p=0.54). CONCLUSION: Our results confirmed a significant association of APOE epsilon4 carrier status with AD. No association was observed for CLU and PICALM with AD. This might be due to a different genetic background. There are no previous reports of these polymorphisms in an Indian cohort. Future Indian AD studies should investigate additional SNPs in a larger sample size in these genes.},\n\tlanguage = {eng},\n\tjournal = {Asian journal of psychiatry},\n\tauthor = {Shankarappa, Bhagyalakshmi Mallapura and Kota, Lakshmi Narayanan and Purushottam, Meera and Nagpal, Kavita and Mukherjee, Odity and Viswanath, Biju and Varghese, Mathew and Bharath, Srikala and Jain, Sanjeev},\n\tmonth = jun,\n\tyear = {2017},\n\tpmid = {28558900},\n\tnote = {Place: Netherlands},\n\tkeywords = {Aged, Alzheimer Disease/*genetics, Apolipoprotein E4/genetics, Clusterin/*genetics, Female, Humans, India, Male, Middle Aged, Monomeric Clathrin Assembly Proteins/*genetics, Polymorphism, Single Nucleotide, Risk},\n\tpages = {7--11},\n}\n\n","author_short":["Shankarappa, B. M.","Kota, L. 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