@ARTICLE{Shen1988-bf,
  title    = "Development of {GABA} responsiveness in embryonic turtle cortical
              neurons",
  author   = "Shen, J M and Huguenard, J R and Kriegstein, A R",
  abstract = "The whole-cell patch-clamp method was used to study the
              development of functional GABA receptors in cortical neurons
              dissociated from embryonic turtles. GABA elicited an increase in
              membrane conductance, even from cells obtained from the earliest
              stages of corticogenesis. The GABA-mediated conductance had a
              mean value 7.4 times greater than membrane 'leak' conductance and
              increased with developmental age. In all stages studied, the
              response inverted polarity at a value approximating ECl- and was
              blocked by applications of bicuculline, suggesting that it was
              mediated by GABAA receptors. GABA receptors are thus present and
              functional very early in corticogenesis, preceding
              electrogenesis, synaptogenesis, and full neuronal
              differentiation.",
  journal  = "Neurosci Lett",
  volume   =  89,
  number   =  3,
  pages    = "335--341",
  month    =  jul,
  year     =  1988,
  address  = "Ireland",
  language = "en"
}

{"_id":"wSCyRn5hRtueQ4JoD","bibbaseid":"shen-huguenard-kriegstein-developmentofgabaresponsivenessinembryonicturtlecorticalneurons-1988","author_short":["Shen, J M","Huguenard, J R","Kriegstein, A R"],"bibdata":{"bibtype":"article","type":"article","title":"Development of GABA responsiveness in embryonic turtle cortical neurons","author":[{"propositions":[],"lastnames":["Shen"],"firstnames":["J","M"],"suffixes":[]},{"propositions":[],"lastnames":["Huguenard"],"firstnames":["J","R"],"suffixes":[]},{"propositions":[],"lastnames":["Kriegstein"],"firstnames":["A","R"],"suffixes":[]}],"abstract":"The whole-cell patch-clamp method was used to study the development of functional GABA receptors in cortical neurons dissociated from embryonic turtles. GABA elicited an increase in membrane conductance, even from cells obtained from the earliest stages of corticogenesis. The GABA-mediated conductance had a mean value 7.4 times greater than membrane 'leak' conductance and increased with developmental age. In all stages studied, the response inverted polarity at a value approximating ECl- and was blocked by applications of bicuculline, suggesting that it was mediated by GABAA receptors. GABA receptors are thus present and functional very early in corticogenesis, preceding electrogenesis, synaptogenesis, and full neuronal differentiation.","journal":"Neurosci Lett","volume":"89","number":"3","pages":"335–341","month":"July","year":"1988","address":"Ireland","language":"en","bibtex":"@ARTICLE{Shen1988-bf,\n title = \"Development of {GABA} responsiveness in embryonic turtle cortical\n neurons\",\n author = \"Shen, J M and Huguenard, J R and Kriegstein, A R\",\n abstract = \"The whole-cell patch-clamp method was used to study the\n development of functional GABA receptors in cortical neurons\n dissociated from embryonic turtles. GABA elicited an increase in\n membrane conductance, even from cells obtained from the earliest\n stages of corticogenesis. The GABA-mediated conductance had a\n mean value 7.4 times greater than membrane 'leak' conductance and\n increased with developmental age. In all stages studied, the\n response inverted polarity at a value approximating ECl- and was\n blocked by applications of bicuculline, suggesting that it was\n mediated by GABAA receptors. GABA receptors are thus present and\n functional very early in corticogenesis, preceding\n electrogenesis, synaptogenesis, and full neuronal\n differentiation.\",\n journal = \"Neurosci Lett\",\n volume = 89,\n number = 3,\n pages = \"335--341\",\n month = jul,\n year = 1988,\n address = \"Ireland\",\n language = \"en\"\n}\n\n","author_short":["Shen, J M","Huguenard, J R","Kriegstein, A R"],"key":"Shen1988-bf","id":"Shen1988-bf","bibbaseid":"shen-huguenard-kriegstein-developmentofgabaresponsivenessinembryonicturtlecorticalneurons-1988","role":"author","urls":{},"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/f/EJMp3HRuxirjxpcXh/references.bib","dataSources":["sAFYeB74DpbdXM9NN","4zx9n2tbeLTix3Wxr","k3cdWrThyTh5o59Rm","hq9pebjzmsTuyxGGx","h8Atv2SAy4PmShg5j"],"keywords":[],"search_terms":["development","gaba","responsiveness","embryonic","turtle","cortical","neurons","shen","huguenard","kriegstein"],"title":"Development of GABA responsiveness in embryonic turtle cortical neurons","year":1988}