Exploratory Analysis of Glyburide as a Novel Therapy for Preventing Brain Swelling. Sheth, K. N., Taylor Kimberly, W., Elm, J. J., Kent, T. A., Yoo, A. J., Thomalla, G., Campbell, B., Donnan, G. A., Davis, S. M., Albers, G. W., Jacobson, S., del Zoppo, G., Marc Simard, J., Stern, B. J., & Mandava, P. Neurocritical Care, 21(1):43–51, August, 2014. ![Exploratory Analysis of Glyburide as a Novel Therapy for Preventing Brain Swelling [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Background Malignant infarction is characterized by the formation of cerebral edema, and medical treatment is limited. Preclinical data suggest that glyburide, an inhibitor of SUR1-TRPM4, is effective in preventing edema. We previously reported feasibility of the GAMES-Pilot study, a two-center prospective, open label, phase IIa trial of 10 subjects at high risk for malignant infarction based on diffusion weighted imaging (DWI) threshold of 82 cm3 treated with RP-1127 (glyburide for injection). In this secondary analysis, we tested the hypothesis that RP-1127 may be efficacious in preventing poor outcome when compared to controls.
@article{sheth_exploratory_2014,
title = {Exploratory {Analysis} of {Glyburide} as a {Novel} {Therapy} for {Preventing} {Brain} {Swelling}},
volume = {21},
issn = {1541-6933, 1556-0961},
url = {http://link.springer.com/10.1007/s12028-014-9970-2},
doi = {10.1007/s12028-014-9970-2},
abstract = {Background Malignant infarction is characterized by the formation of cerebral edema, and medical treatment is limited. Preclinical data suggest that glyburide, an inhibitor of SUR1-TRPM4, is effective in preventing edema. We previously reported feasibility of the GAMES-Pilot study, a two-center prospective, open label, phase IIa trial of 10 subjects at high risk for malignant infarction based on diffusion weighted imaging (DWI) threshold of 82 cm3 treated with RP-1127 (glyburide for injection). In this secondary analysis, we tested the hypothesis that RP-1127 may be efficacious in preventing poor outcome when compared to controls.},
language = {en},
number = {1},
urldate = {2021-02-12},
journal = {Neurocritical Care},
author = {Sheth, Kevin N. and Taylor Kimberly, W. and Elm, Jordan J. and Kent, Thomas A. and Yoo, Albert J. and Thomalla, Götz and Campbell, Bruce and Donnan, Geoffrey A. and Davis, Stephen M. and Albers, Gregory W. and Jacobson, Sven and del Zoppo, Gregory and Marc Simard, J. and Stern, Barney J. and Mandava, Pitchaiah},
month = aug,
year = {2014},
pages = {43--51},
}
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