@article{shi_understanding_2023,
	title = {Understanding the risk of transmission of respiratory viral infections in childcare centres: protocol for the {DISeases} {TrANsmission} in {ChildcarE} ({DISTANCE})  multicentre cohort study.},
	volume = {10},
	copyright = {© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.},
	issn = {2052-4439},
	doi = {10.1136/bmjresp-2023-001617},
	abstract = {INTRODUCTION: Childcare centre is considered a high-risk setting for transmission of respiratory viruses. Further evidence is needed to understand the risk of  transmission in childcare centres. To this end, we established the DISeases  TrANsmission in ChildcarE (DISTANCE) study to understand the interaction among  contact patterns, detection of respiratory viruses from environment samples and  transmission of viral infections in childcare centres. METHODS AND ANALYSIS: The  DISTANCE study is a prospective cohort study in multiple childcare centres of  Jiangsu Province, China. Study subjects will be childcare attendees and teaching  staff of different grades. A range of information will be collected from the  study subjects and participating childcare centres, including attendance, contact  behaviours (collected by onsite observers), respiratory viral infection (weekly  respiratory throat swabs tested by multiplex PCR), presence of respiratory  viruses on touch surfaces of childcare centres and weekly follow-up survey on  respiratory symptoms and healthcare seeking among subjects tested positive for  any respiratory viruses. Detection patterns of respiratory viruses from study  subjects and environment samples, contact patterns, and transmission risk will be  analysed by developing statistical and mathematical models as appropriate. The  study has been initiated in September 2022 in 1 childcare centre in Wuxi City,  with a total of 104 children and 12 teaching staff included in the cohort; data  collection and follow-up is ongoing. One more childcare centre in Nanjing City  (anticipated to include 100 children and 10 teaching staff) will start  recruitment in 2023. ETHICS AND DISSEMINATION: The study has received ethics  approval from Nanjing Medical University Ethics Committee (No. 2022-936) and  ethics approval from Wuxi Center for Disease Control and Prevention Ethics  Committee (No. 2022-011). We plan to disseminate the study findings mainly  through publications in peer-reviewed journals and presentations in academic  conferences. Aggregated research data will be shared freely to researchers.},
	language = {eng},
	number = {1},
	journal = {BMJ open respiratory research},
	author = {Shi, Chao and Wang, Xin and Ye, Sheng and Deng, Shuyu and Cong, Bingbing and Lu, Bing and Li, You},
	month = apr,
	year = {2023},
	pmid = {37028911},
	pmcid = {PMC10083867},
	note = {Place: England},
	keywords = {Humans, Prospective Studies, *Virus Diseases/diagnosis/epidemiology, *Viruses, Child, Child Care, Child Day Care Centers, Multicenter Studies as Topic, Respiratory Infection, Viral infection},
}

{"_id":"2GrC3p7cZ63qgxou4","bibbaseid":"shi-wang-ye-deng-cong-lu-li-understandingtheriskoftransmissionofrespiratoryviralinfectionsinchildcarecentresprotocolforthediseasestransmissioninchildcaredistancemulticentrecohortstudy-2023","author_short":["Shi, C.","Wang, X.","Ye, S.","Deng, S.","Cong, B.","Lu, B.","Li, Y."],"bibdata":{"bibtype":"article","type":"article","title":"Understanding the risk of transmission of respiratory viral infections in childcare centres: protocol for the DISeases TrANsmission in ChildcarE (DISTANCE) multicentre cohort study.","volume":"10","copyright":"© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.","issn":"2052-4439","doi":"10.1136/bmjresp-2023-001617","abstract":"INTRODUCTION: Childcare centre is considered a high-risk setting for transmission of respiratory viruses. Further evidence is needed to understand the risk of transmission in childcare centres. To this end, we established the DISeases TrANsmission in ChildcarE (DISTANCE) study to understand the interaction among contact patterns, detection of respiratory viruses from environment samples and transmission of viral infections in childcare centres. METHODS AND ANALYSIS: The DISTANCE study is a prospective cohort study in multiple childcare centres of Jiangsu Province, China. Study subjects will be childcare attendees and teaching staff of different grades. A range of information will be collected from the study subjects and participating childcare centres, including attendance, contact behaviours (collected by onsite observers), respiratory viral infection (weekly respiratory throat swabs tested by multiplex PCR), presence of respiratory viruses on touch surfaces of childcare centres and weekly follow-up survey on respiratory symptoms and healthcare seeking among subjects tested positive for any respiratory viruses. Detection patterns of respiratory viruses from study subjects and environment samples, contact patterns, and transmission risk will be analysed by developing statistical and mathematical models as appropriate. The study has been initiated in September 2022 in 1 childcare centre in Wuxi City, with a total of 104 children and 12 teaching staff included in the cohort; data collection and follow-up is ongoing. One more childcare centre in Nanjing City (anticipated to include 100 children and 10 teaching staff) will start recruitment in 2023. ETHICS AND DISSEMINATION: The study has received ethics approval from Nanjing Medical University Ethics Committee (No. 2022-936) and ethics approval from Wuxi Center for Disease Control and Prevention Ethics Committee (No. 2022-011). We plan to disseminate the study findings mainly through publications in peer-reviewed journals and presentations in academic conferences. Aggregated research data will be shared freely to researchers.","language":"eng","number":"1","journal":"BMJ open respiratory research","author":[{"propositions":[],"lastnames":["Shi"],"firstnames":["Chao"],"suffixes":[]},{"propositions":[],"lastnames":["Wang"],"firstnames":["Xin"],"suffixes":[]},{"propositions":[],"lastnames":["Ye"],"firstnames":["Sheng"],"suffixes":[]},{"propositions":[],"lastnames":["Deng"],"firstnames":["Shuyu"],"suffixes":[]},{"propositions":[],"lastnames":["Cong"],"firstnames":["Bingbing"],"suffixes":[]},{"propositions":[],"lastnames":["Lu"],"firstnames":["Bing"],"suffixes":[]},{"propositions":[],"lastnames":["Li"],"firstnames":["You"],"suffixes":[]}],"month":"April","year":"2023","pmid":"37028911","pmcid":"PMC10083867","note":"Place: England","keywords":"Humans, Prospective Studies, *Virus Diseases/diagnosis/epidemiology, *Viruses, Child, Child Care, Child Day Care Centers, Multicenter Studies as Topic, Respiratory Infection, Viral infection","bibtex":"@article{shi_understanding_2023,\n\ttitle = {Understanding the risk of transmission of respiratory viral infections in childcare centres: protocol for the {DISeases} {TrANsmission} in {ChildcarE} ({DISTANCE}) multicentre cohort study.},\n\tvolume = {10},\n\tcopyright = {© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.},\n\tissn = {2052-4439},\n\tdoi = {10.1136/bmjresp-2023-001617},\n\tabstract = {INTRODUCTION: Childcare centre is considered a high-risk setting for transmission of respiratory viruses. Further evidence is needed to understand the risk of transmission in childcare centres. To this end, we established the DISeases TrANsmission in ChildcarE (DISTANCE) study to understand the interaction among contact patterns, detection of respiratory viruses from environment samples and transmission of viral infections in childcare centres. METHODS AND ANALYSIS: The DISTANCE study is a prospective cohort study in multiple childcare centres of Jiangsu Province, China. Study subjects will be childcare attendees and teaching staff of different grades. A range of information will be collected from the study subjects and participating childcare centres, including attendance, contact behaviours (collected by onsite observers), respiratory viral infection (weekly respiratory throat swabs tested by multiplex PCR), presence of respiratory viruses on touch surfaces of childcare centres and weekly follow-up survey on respiratory symptoms and healthcare seeking among subjects tested positive for any respiratory viruses. Detection patterns of respiratory viruses from study subjects and environment samples, contact patterns, and transmission risk will be analysed by developing statistical and mathematical models as appropriate. The study has been initiated in September 2022 in 1 childcare centre in Wuxi City, with a total of 104 children and 12 teaching staff included in the cohort; data collection and follow-up is ongoing. One more childcare centre in Nanjing City (anticipated to include 100 children and 10 teaching staff) will start recruitment in 2023. ETHICS AND DISSEMINATION: The study has received ethics approval from Nanjing Medical University Ethics Committee (No. 2022-936) and ethics approval from Wuxi Center for Disease Control and Prevention Ethics Committee (No. 2022-011). We plan to disseminate the study findings mainly through publications in peer-reviewed journals and presentations in academic conferences. 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