Dynamic nature of atrial fibrillation substrate during development and reversal of heart failure in dogs. Shinagawa, K., Shi, Y., Tardif, J., Leung, T., & Nattel, S. j-C, 105(22):2672--2678, June, 2002. bibtex @Article{RSM:Shi2002,
author = "K. Shinagawa and Y.F. Shi and J.C. Tardif and T.K.
Leung and S. Nattel",
title = "Dynamic nature of atrial fibrillation substrate during
development and reversal of heart failure in dogs.",
journal = j-C,
year = "2002",
month = jun,
volume = "105",
number = "22",
pages = "2672--2678",
robnote = "Chronically instrumented dogs were subjected to 4 to 6
weeks of ventricular tachypacing (VTP; 220 to 240 bpm)
to induce congestive heart failure (CHF), followed by a
5-week recovery period leading to hemodynamic
normalization at 5-week recovery (Wk5(rec)). The
duration of burst pacing-induced AF under
ketamine/diazepam/isoflurane anesthesia increased
progressively during VTP and recovered toward baseline
during the recovery period, paralleling changes in
atrial dimensions. However, even at full recovery,
sustained AF could still be induced under relatively
vagotonic morphine/chloralose anesthesia. Wk5(rec) dogs
showed no recovery of CHF-induced atrial fibrosis
(3.1+/-0.3\% for controls versus 10.7+/-1.0\% for CHF
and 12.0+/-0.8\% for Wk5(rec) dogs) or local conduction
abnormalities (conduction heterogeneity index 1.8+/-0.1
in controls versus 2.3+/-0.1 in CHF and 2.2+/-0.2 in
Wk5(rec) dogs). One week of atrial tachypacing failed
to affect the right atrial effective refractory period
significantly in CHF dogs but caused highly significant
effective refractory period reductions and atrial
vulnerability increases in Wk5(rec) dogs. CONCLUSIONS:
Reversal of CHF is followed by normalized atrial
function and decreased duration of AF; however,
fibrosis and conduction abnormalities are not
reversible, and a substrate that can support prolonged
AF remains. Early intervention to prevent fixed
structural abnormalities may be important in patients
with conditions that predispose to the arrhythmia.",
bibdate = "Sun Jun 1 18:41:50 2008",
}
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{"_id":"gxi9MrkWAF27p8YAh","bibbaseid":"shinagawa-shi-tardif-leung-nattel-dynamicnatureofatrialfibrillationsubstrateduringdevelopmentandreversalofheartfailureindogs-2002","downloads":0,"creationDate":"2016-07-01T21:38:40.757Z","title":"Dynamic nature of atrial fibrillation substrate during development and reversal of heart failure in dogs.","author_short":["Shinagawa, K.","Shi, Y.","Tardif, J.","Leung, T.","Nattel, S."],"year":2002,"bibtype":"article","biburl":"http://www.sci.utah.edu/~macleod/Bibtex/biglit.bib","bibdata":{"bibtype":"article","type":"article","author":[{"firstnames":["K."],"propositions":[],"lastnames":["Shinagawa"],"suffixes":[]},{"firstnames":["Y.F."],"propositions":[],"lastnames":["Shi"],"suffixes":[]},{"firstnames":["J.C."],"propositions":[],"lastnames":["Tardif"],"suffixes":[]},{"firstnames":["T.K."],"propositions":[],"lastnames":["Leung"],"suffixes":[]},{"firstnames":["S."],"propositions":[],"lastnames":["Nattel"],"suffixes":[]}],"title":"Dynamic nature of atrial fibrillation substrate during development and reversal of heart failure in dogs.","journal":"j-C","year":"2002","month":"June","volume":"105","number":"22","pages":"2672--2678","robnote":"Chronically instrumented dogs were subjected to 4 to 6 weeks of ventricular tachypacing (VTP; 220 to 240 bpm) to induce congestive heart failure (CHF), followed by a 5-week recovery period leading to hemodynamic normalization at 5-week recovery (Wk5(rec)). The duration of burst pacing-induced AF under ketamine/diazepam/isoflurane anesthesia increased progressively during VTP and recovered toward baseline during the recovery period, paralleling changes in atrial dimensions. However, even at full recovery, sustained AF could still be induced under relatively vagotonic morphine/chloralose anesthesia. Wk5(rec) dogs showed no recovery of CHF-induced atrial fibrosis (3.1+/-0.3% for controls versus 10.7+/-1.0% for CHF and 12.0+/-0.8% for Wk5(rec) dogs) or local conduction abnormalities (conduction heterogeneity index 1.8+/-0.1 in controls versus 2.3+/-0.1 in CHF and 2.2+/-0.2 in Wk5(rec) dogs). One week of atrial tachypacing failed to affect the right atrial effective refractory period significantly in CHF dogs but caused highly significant effective refractory period reductions and atrial vulnerability increases in Wk5(rec) dogs. CONCLUSIONS: Reversal of CHF is followed by normalized atrial function and decreased duration of AF; however, fibrosis and conduction abnormalities are not reversible, and a substrate that can support prolonged AF remains. Early intervention to prevent fixed structural abnormalities may be important in patients with conditions that predispose to the arrhythmia.","bibdate":"Sun Jun 1 18:41:50 2008","bibtex":"@Article{RSM:Shi2002,\n author = \"K. Shinagawa and Y.F. Shi and J.C. Tardif and T.K.\n Leung and S. Nattel\",\n title = \"Dynamic nature of atrial fibrillation substrate during\n development and reversal of heart failure in dogs.\",\n journal = j-C,\n year = \"2002\",\n month = jun,\n volume = \"105\",\n number = \"22\",\n pages = \"2672--2678\",\n robnote = \"Chronically instrumented dogs were subjected to 4 to 6\n weeks of ventricular tachypacing (VTP; 220 to 240 bpm)\n to induce congestive heart failure (CHF), followed by a\n 5-week recovery period leading to hemodynamic\n normalization at 5-week recovery (Wk5(rec)). The\n duration of burst pacing-induced AF under\n ketamine/diazepam/isoflurane anesthesia increased\n progressively during VTP and recovered toward baseline\n during the recovery period, paralleling changes in\n atrial dimensions. However, even at full recovery,\n sustained AF could still be induced under relatively\n vagotonic morphine/chloralose anesthesia. Wk5(rec) dogs\n showed no recovery of CHF-induced atrial fibrosis\n (3.1+/-0.3\\% for controls versus 10.7+/-1.0\\% for CHF\n and 12.0+/-0.8\\% for Wk5(rec) dogs) or local conduction\n abnormalities (conduction heterogeneity index 1.8+/-0.1\n in controls versus 2.3+/-0.1 in CHF and 2.2+/-0.2 in\n Wk5(rec) dogs). One week of atrial tachypacing failed\n to affect the right atrial effective refractory period\n significantly in CHF dogs but caused highly significant\n effective refractory period reductions and atrial\n vulnerability increases in Wk5(rec) dogs. CONCLUSIONS:\n Reversal of CHF is followed by normalized atrial\n function and decreased duration of AF; however,\n fibrosis and conduction abnormalities are not\n reversible, and a substrate that can support prolonged\n AF remains. Early intervention to prevent fixed\n structural abnormalities may be important in patients\n with conditions that predispose to the arrhythmia.\",\n bibdate = \"Sun Jun 1 18:41:50 2008\",\n}\n\n","author_short":["Shinagawa, K.","Shi, Y.","Tardif, J.","Leung, T.","Nattel, S."],"key":"RSM:Shi2002","id":"RSM:Shi2002","bibbaseid":"shinagawa-shi-tardif-leung-nattel-dynamicnatureofatrialfibrillationsubstrateduringdevelopmentandreversalofheartfailureindogs-2002","role":"author","urls":{},"downloads":0,"html":""},"search_terms":["dynamic","nature","atrial","fibrillation","substrate","during","development","reversal","heart","failure","dogs","shinagawa","shi","tardif","leung","nattel"],"keywords":[],"authorIDs":[],"dataSources":["5HG3Kp8zRwDd7FotB"]}