@InProceedings{Shtam2017a,
  author    = {Shtam, T. and Samsonov, R. and Kamyshinsky, R. and Pantina, R. and Verlov, N. and Vasiliev, A. and Konevega, A.~L. and Malek, A.~V.},
  booktitle = {Physics of Cancer: Interdisciplinary Problems and Clinical Applications},
  title     = {Exosomes: Some approaches to cancer diagnosis and therapy},
  year      = {2017},
  month     = sep,
  pages     = {020066},
  series    = {American Institute of Physics Conference Series},
  volume    = {1882},
  abstract  = {Exosomes are membrane-bound, intercellular communication shuttle         vesicles that are defined by their endocytic origin and size         range of 30-120 nm. Secreted by nearly all mammalian cell types         and present in bodily fluids, exosomes confer messages between         cells, by transporting functionally relevant proteins, nucleic         acids, and lipids. The capability of tumor exosomes to house         tumorigenic information and induce cellular responses that         promote disease pathogenesis make tumor exosomes an attractive         tool in identifying cancer biomarkers and exploiting exosomes         for therapy. In this paper, we sum up our previous findings to         utilize exosomes as biomarkers for early detection, diagnosis         and therapy selection of prostate and thyroid cancer and present         our results on exosomes in colon cancer. Some of plasma exosomal         miRNAs showed their potential as diagnostic markers for colon         cancer. All together, the data suggested the potentials of         circulating exosomal miRNAs as liquid biopsy markers for cancer.         Here we also present the possibilities of delivering therapeutic         molecules by exosomes. Previously, we had demonstrated the         potential of exosome-mediated siRNA delivery. Here, we present         the possibility of carrying the exogenous p53 protein by         exosomes in vitro.},
  doi       = {10.1063/1.5001645},
  eid       = {020066},
  url       = {https://ui.adsabs.harvard.edu/abs/2017AIPC.1882b0066S},
}

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Secreted by nearly all mammalian cell types and present in bodily fluids, exosomes confer messages between cells, by transporting functionally relevant proteins, nucleic acids, and lipids. The capability of tumor exosomes to house tumorigenic information and induce cellular responses that promote disease pathogenesis make tumor exosomes an attractive tool in identifying cancer biomarkers and exploiting exosomes for therapy. In this paper, we sum up our previous findings to utilize exosomes as biomarkers for early detection, diagnosis and therapy selection of prostate and thyroid cancer and present our results on exosomes in colon cancer. Some of plasma exosomal miRNAs showed their potential as diagnostic markers for colon cancer. All together, the data suggested the potentials of circulating exosomal miRNAs as liquid biopsy markers for cancer. Here we also present the possibilities of delivering therapeutic molecules by exosomes. Previously, we had demonstrated the potential of exosome-mediated siRNA delivery. Here, we present the possibility of carrying the exogenous p53 protein by exosomes in vitro.","doi":"10.1063/1.5001645","eid":"020066","url":"https://ui.adsabs.harvard.edu/abs/2017AIPC.1882b0066S","bibtex":"@InProceedings{Shtam2017a,\n author = {Shtam, T. and Samsonov, R. and Kamyshinsky, R. and Pantina, R. and Verlov, N. and Vasiliev, A. and Konevega, A.~L. and Malek, A.~V.},\n booktitle = {Physics of Cancer: Interdisciplinary Problems and Clinical Applications},\n title = {Exosomes: Some approaches to cancer diagnosis and therapy},\n year = {2017},\n month = sep,\n pages = {020066},\n series = {American Institute of Physics Conference Series},\n volume = {1882},\n abstract = {Exosomes are membrane-bound, intercellular communication shuttle vesicles that are defined by their endocytic origin and size range of 30-120 nm. Secreted by nearly all mammalian cell types and present in bodily fluids, exosomes confer messages between cells, by transporting functionally relevant proteins, nucleic acids, and lipids. The capability of tumor exosomes to house tumorigenic information and induce cellular responses that promote disease pathogenesis make tumor exosomes an attractive tool in identifying cancer biomarkers and exploiting exosomes for therapy. In this paper, we sum up our previous findings to utilize exosomes as biomarkers for early detection, diagnosis and therapy selection of prostate and thyroid cancer and present our results on exosomes in colon cancer. Some of plasma exosomal miRNAs showed their potential as diagnostic markers for colon cancer. All together, the data suggested the potentials of circulating exosomal miRNAs as liquid biopsy markers for cancer. Here we also present the possibilities of delivering therapeutic molecules by exosomes. Previously, we had demonstrated the potential of exosome-mediated siRNA delivery. Here, we present the possibility of carrying the exogenous p53 protein by exosomes in vitro.},\n doi = {10.1063/1.5001645},\n eid = {020066},\n url = {https://ui.adsabs.harvard.edu/abs/2017AIPC.1882b0066S},\n}\n\n","author_short":["Shtam, T.","Samsonov, R.","Kamyshinsky, R.","Pantina, R.","Verlov, N.","Vasiliev, A.","Konevega, A.","Malek, A."],"key":"Shtam2017a","id":"Shtam2017a","bibbaseid":"shtam-samsonov-kamyshinsky-pantina-verlov-vasiliev-konevega-malek-exosomessomeapproachestocancerdiagnosisandtherapy-2017","role":"author","urls":{"Paper":"https://ui.adsabs.harvard.edu/abs/2017AIPC.1882b0066S"},"metadata":{"authorlinks":{}},"downloads":1},"bibtype":"inproceedings","biburl":"https://bio.pnpi.nrcki.ru/wp-content/uploads/2024/02/lmbni_2023.txt","creationDate":"2019-11-05T13:48:15.610Z","downloads":1,"keywords":[],"search_terms":["exosomes","approaches","cancer","diagnosis","therapy","shtam","samsonov","kamyshinsky","pantina","verlov","vasiliev","konevega","malek"],"title":"Exosomes: Some approaches to cancer diagnosis and therapy","year":2017,"dataSources":["TRehu3DvnmfePetpJ","cJ5ZpoJMJycEnWRby","ANN8J2YQK3QRMfMc8","yJybRvieupxj5bbie","x6wsWRRxTjczPPh9A"]}