@CONFERENCE{Shtam2017,
author={Shtam, T. and Samsonov, R. and Kamyshinsky, R. and Pantina, R. and Verlov, N. and Vasiliev, A. and Konevega, A.L. and Malek, A.V.},
title={Exosomes: Some approaches to cancer diagnosis and therapy},
journal={AIP Conference Proceedings},
year={2017},
volume={1882},
doi={10.1063/1.5001645},
art_number={020066},
note={cited By 5; Conference of International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017 ; Conference Date: 23 May 2017 Through 26 May 2017;  Conference Code:133914},
url={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85041662414&doi=10.1063%2f1.5001645&partnerID=40&md5=d908b66243d4ade3a27c45bad492f886},
affiliation={Petersburg Nuclear Physics Institute of National Research Centre, Kurchatov Institute, Gatchina, Russian Federation; Petrov Institute of Oncology, Saint-Petersburg, Russian Federation; Ltd. Oncosystem, Skolkovo, Russian Federation; Peter the Great Saint-Petersburg Polytechnic University, St. Petersburg, Russian Federation; National Research Center, Kurchatov Institute, Moscow, Russian Federation},
abstract={Exosomes are membrane-bound, intercellular communication shuttle vesicles that are defined by their endocytic origin and size range of 30-120 nm. Secreted by nearly all mammalian cell types and present in bodily fluids, exosomes confer messages between cells, by transporting functionally relevant proteins, nucleic acids, and lipids. The capability of tumor exosomes to house tumorigenic information and induce cellular responses that promote disease pathogenesis make tumor exosomes an attractive tool in identifying cancer biomarkers and exploiting exosomes for therapy. In this paper, we sum up our previous findings to utilize exosomes as biomarkers for early detection, diagnosis and therapy selection of prostate and thyroid cancer and present our results on exosomes in colon cancer. Some of plasma exosomal miRNAs showed their potential as diagnostic markers for colon cancer. All together, the data suggested the potentials of circulating exosomal miRNAs as liquid biopsy markers for cancer. Here we also present the possibilities of delivering therapeutic molecules by exosomes. Previously, we had demonstrated the potential of exosome-mediated siRNA delivery. Here, we present the possibility of carrying the exogenous p53 protein by exosomes in vitro. © 2017 Author(s).},
correspondence_address1={Shtam, T.; Petersburg Nuclear Physics Institute of National Research Centre, Kurchatov InstituteRussian Federation; email: tatyana_shtam@mail.ru},
editor={Gutmanas E.Y., Naimark O.B., Sharkeev Y.P.},
sponsors={Institute of Continuous Media Mechanics of UrB RAS; Institute of Strength Physics and Materials Science of SB RAS; National Research Tomsk Polytechnic University; National Research Tomsk State University; Tomsk Research Institute of Oncology},
publisher={American Institute of Physics Inc.},
issn={0094243X},
isbn={9780735415621},
language={English},
abbrev_source_title={AIP Conf. Proc.},
document_type={Conference Paper},
source={Scopus},
}

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In this paper, we sum up our previous findings to utilize exosomes as biomarkers for early detection, diagnosis and therapy selection of prostate and thyroid cancer and present our results on exosomes in colon cancer. Some of plasma exosomal miRNAs showed their potential as diagnostic markers for colon cancer. All together, the data suggested the potentials of circulating exosomal miRNAs as liquid biopsy markers for cancer. Here we also present the possibilities of delivering therapeutic molecules by exosomes. Previously, we had demonstrated the potential of exosome-mediated siRNA delivery. 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