@ARTICLE{Shtam2004126,
author={Shtam, T.A. and Vostrukhina, O.A. and Gulyaev, A.V. and Pozharisskij, K.M. and Lantsov, V.A.},
title={General changes of progression of hereditary nonpolyposis colorectal cancer},
journal={Doklady Akademii Nauk},
year={2004},
volume={395},
number={1},
pages={126-131},
note={cited By 0},
url={https://www.scopus.com/inward/record.uri?eid=2-s2.0-8644283771&partnerID=40&md5=c9a985e57637b1209b06c1acb79c9333},
affiliation={Peterburgskij Inst. Yadernoj Fiziki, RAN, Sankt-Peterburg, Russian Federation},
abstract={Retrospective analysis of genetic changes in cells of a patient with inheritable nonpolypoid large intestine cancer has been carried out. Neoplastic progression appeared to be a result of damages in a system of non-paired DNA bases correction. New inheritable mutation in hMLH1 gene has been described. This mutation induced 3 consecutive stages of disease: 1) appearance of mutations, aggravating the damage of DNA reparation system; 2) accumulation of mutations and metastasizing of transformed cell; 3) independent development of new clones and appearance of a large number of tumors.},
correspondence_address1={Shtam, T.A.; Peterburgskij Inst. Yadernoj Fiziki, RAN, Sankt-Peterburg, Russian Federation},
issn={08695652},
coden={DAKNE},
language={Russian},
abbrev_source_title={Dokl Akad Nauk},
document_type={Article},
source={Scopus},
}

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