@article{RN153,
   author = {Shukla-Dave, A. and Lee, N. Y. and Jansen, J. F. and Thaler, H. T. and Stambuk, H. E. and Fury, M. G. and Patel, S. G. and Moreira, A. L. and Sherman, E. and Karimi, S. and Wang, Y. and Kraus, D. and Shah, J. P. and Pfister, D. G. and Koutcher, J. A.},
   title = {Dynamic contrast-enhanced magnetic resonance imaging as a predictor of outcome in head-and-neck squamous cell carcinoma patients with nodal metastases},
   journal = {Int J Radiat Oncol Biol Phys},
   volume = {82},
   number = {5},
   pages = {1837-44},
   note = {Shukla-Dave, Amita
Lee, Nancy Y
Jansen, Jacobus F A
Thaler, Howard T
Stambuk, Hilda E
Fury, Matthew G
Patel, Snehal G
Moreira, Andre L
Sherman, Eric
Karimi, Sasan
Wang, Ya
Kraus, Dennis
Shah, Jatin P
Pfister, David G
Koutcher, Jason A
eng
R01 CA115895/CA/NCI NIH HHS/
R01 CA115895-05/CA/NCI NIH HHS/
1 R01 CA115895/CA/NCI NIH HHS/
Research Support, N.I.H., Extramural
2011/05/24 06:00
Int J Radiat Oncol Biol Phys. 2012 Apr 1;82(5):1837-44. doi: 10.1016/j.ijrobp.2011.03.006. Epub 2011 May 19.},
   abstract = {PURPOSE: Dynamic contrast-enhanced MRI (DCE-MRI) can provide information regarding tumor perfusion and permeability and has shown prognostic value in certain tumors types. The goal of this study was to assess the prognostic value of pretreatment DCE-MRI in head and neck squamous cell carcinoma (HNSCC) patients with nodal disease undergoing chemoradiation therapy or surgery. METHODS AND MATERIALS: Seventy-four patients with histologically proven squamous cell carcinoma and neck nodal metastases were eligible for the study. Pretreatment DCE-MRI was performed on a 1.5T MRI. Clinical follow-up was a minimum of 12 months. DCE-MRI data were analyzed using the Tofts model. DCE-MRI parameters were related to treatment outcome (progression-free survival [PFS] and overall survival [OS]). Patients were grouped as no evidence of disease (NED), alive with disease (AWD), dead with disease (DOD), or dead of other causes (DOC). Prognostic significance was assessed using the log-rank test for single variables and Cox proportional hazards regression for combinations of variables. RESULTS: At last clinical follow-up, for Stage III, all 12 patients were NED. For Stage IV, 43 patients were NED, 4 were AWD, 11 were DOD, and 4 were DOC. K(trans) is volume transfer constant. In a stepwise Cox regression, skewness of K(trans) (volume transfer constant) was the strongest predictor for Stage IV patients (PFS and OS: p <0.001). CONCLUSION: Our study shows that skewness of K(trans) was the strongest predictor of PFS and OS in Stage IV HNSCC patients with nodal disease. This study suggests an important role for pretreatment DCE-MRI parameter K(trans) as a predictor of outcome in these patients.},
   keywords = {Adult
Aged
Aged, 80 and over
Analysis of Variance
Carcinoma, Squamous Cell/*diagnosis/mortality/pathology/secondary/therapy
Chemoradiotherapy/methods
*Contrast Media
Disease-Free Survival
Female
Follow-Up Studies
Gadolinium DTPA
Humans
Lymphatic Metastasis
Magnetic Resonance Imaging/*methods
Male
Middle Aged
Mouth Neoplasms/*diagnosis/mortality/pathology/secondary/therapy
Neoplasm Staging
Oropharyngeal Neoplasms/*diagnosis/mortality/pathology/secondary/therapy
Proportional Hazards Models
Retrospective Studies
Statistics, Nonparametric
Treatment Outcome},
   ISSN = {1879-355X (Electronic)
0360-3016 (Linking)},
   DOI = {10.1016/j.ijrobp.2011.03.006},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/21601373
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177034/pdf/nihms299438.pdf},
   year = {2012},
   type = {Journal Article}
}

{"_id":"nRTWjSHabCfHbDk9D","bibbaseid":"shukladave-lee-jansen-thaler-stambuk-fury-patel-moreira-etal-dynamiccontrastenhancedmagneticresonanceimagingasapredictorofoutcomeinheadandnecksquamouscellcarcinomapatientswithnodalmetastases-2012","downloads":0,"creationDate":"2017-09-02T18:10:13.546Z","title":"Dynamic contrast-enhanced magnetic resonance imaging as a predictor of outcome in head-and-neck squamous cell carcinoma patients with nodal metastases","author_short":["Shukla-Dave, A.","Lee, N. Y.","Jansen, J. F.","Thaler, H. T.","Stambuk, H. E.","Fury, M. G.","Patel, S. G.","Moreira, A. L.","Sherman, E.","Karimi, S.","Wang, Y.","Kraus, D.","Shah, J. P.","Pfister, D. G.","Koutcher, J. A."],"year":2012,"bibtype":"article","biburl":"https://raw.githubusercontent.com/jansenjfa1/bibbase.github.io/master/jansenjfa.bib","bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Shukla-Dave"],"firstnames":["A."],"suffixes":[]},{"propositions":[],"lastnames":["Lee"],"firstnames":["N.","Y."],"suffixes":[]},{"propositions":[],"lastnames":["Jansen"],"firstnames":["J.","F."],"suffixes":[]},{"propositions":[],"lastnames":["Thaler"],"firstnames":["H.","T."],"suffixes":[]},{"propositions":[],"lastnames":["Stambuk"],"firstnames":["H.","E."],"suffixes":[]},{"propositions":[],"lastnames":["Fury"],"firstnames":["M.","G."],"suffixes":[]},{"propositions":[],"lastnames":["Patel"],"firstnames":["S.","G."],"suffixes":[]},{"propositions":[],"lastnames":["Moreira"],"firstnames":["A.","L."],"suffixes":[]},{"propositions":[],"lastnames":["Sherman"],"firstnames":["E."],"suffixes":[]},{"propositions":[],"lastnames":["Karimi"],"firstnames":["S."],"suffixes":[]},{"propositions":[],"lastnames":["Wang"],"firstnames":["Y."],"suffixes":[]},{"propositions":[],"lastnames":["Kraus"],"firstnames":["D."],"suffixes":[]},{"propositions":[],"lastnames":["Shah"],"firstnames":["J.","P."],"suffixes":[]},{"propositions":[],"lastnames":["Pfister"],"firstnames":["D.","G."],"suffixes":[]},{"propositions":[],"lastnames":["Koutcher"],"firstnames":["J.","A."],"suffixes":[]}],"title":"Dynamic contrast-enhanced magnetic resonance imaging as a predictor of outcome in head-and-neck squamous cell carcinoma patients with nodal metastases","journal":"Int J Radiat Oncol Biol Phys","volume":"82","number":"5","pages":"1837-44","note":"Shukla-Dave, Amita Lee, Nancy Y Jansen, Jacobus F A Thaler, Howard T Stambuk, Hilda E Fury, Matthew G Patel, Snehal G Moreira, Andre L Sherman, Eric Karimi, Sasan Wang, Ya Kraus, Dennis Shah, Jatin P Pfister, David G Koutcher, Jason A eng R01 CA115895/CA/NCI NIH HHS/ R01 CA115895-05/CA/NCI NIH HHS/ 1 R01 CA115895/CA/NCI NIH HHS/ Research Support, N.I.H., Extramural 2011/05/24 06:00 Int J Radiat Oncol Biol Phys. 2012 Apr 1;82(5):1837-44. doi: 10.1016/j.ijrobp.2011.03.006. Epub 2011 May 19.","abstract":"PURPOSE: Dynamic contrast-enhanced MRI (DCE-MRI) can provide information regarding tumor perfusion and permeability and has shown prognostic value in certain tumors types. The goal of this study was to assess the prognostic value of pretreatment DCE-MRI in head and neck squamous cell carcinoma (HNSCC) patients with nodal disease undergoing chemoradiation therapy or surgery. METHODS AND MATERIALS: Seventy-four patients with histologically proven squamous cell carcinoma and neck nodal metastases were eligible for the study. Pretreatment DCE-MRI was performed on a 1.5T MRI. Clinical follow-up was a minimum of 12 months. DCE-MRI data were analyzed using the Tofts model. DCE-MRI parameters were related to treatment outcome (progression-free survival [PFS] and overall survival [OS]). Patients were grouped as no evidence of disease (NED), alive with disease (AWD), dead with disease (DOD), or dead of other causes (DOC). Prognostic significance was assessed using the log-rank test for single variables and Cox proportional hazards regression for combinations of variables. RESULTS: At last clinical follow-up, for Stage III, all 12 patients were NED. For Stage IV, 43 patients were NED, 4 were AWD, 11 were DOD, and 4 were DOC. K(trans) is volume transfer constant. In a stepwise Cox regression, skewness of K(trans) (volume transfer constant) was the strongest predictor for Stage IV patients (PFS and OS: p <0.001). CONCLUSION: Our study shows that skewness of K(trans) was the strongest predictor of PFS and OS in Stage IV HNSCC patients with nodal disease. This study suggests an important role for pretreatment DCE-MRI parameter K(trans) as a predictor of outcome in these patients.","keywords":"Adult Aged Aged, 80 and over Analysis of Variance Carcinoma, Squamous Cell/*diagnosis/mortality/pathology/secondary/therapy Chemoradiotherapy/methods *Contrast Media Disease-Free Survival Female Follow-Up Studies Gadolinium DTPA Humans Lymphatic Metastasis Magnetic Resonance Imaging/*methods Male Middle Aged Mouth Neoplasms/*diagnosis/mortality/pathology/secondary/therapy Neoplasm Staging Oropharyngeal Neoplasms/*diagnosis/mortality/pathology/secondary/therapy Proportional Hazards Models Retrospective Studies Statistics, Nonparametric Treatment Outcome","issn":"1879-355X (Electronic) 0360-3016 (Linking)","doi":"10.1016/j.ijrobp.2011.03.006","url":"http://www.ncbi.nlm.nih.gov/pubmed/21601373 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177034/pdf/nihms299438.pdf","year":"2012","bibtex":"@article{RN153,\n author = {Shukla-Dave, A. and Lee, N. Y. and Jansen, J. F. and Thaler, H. T. and Stambuk, H. E. and Fury, M. G. and Patel, S. G. and Moreira, A. L. and Sherman, E. and Karimi, S. and Wang, Y. and Kraus, D. and Shah, J. P. and Pfister, D. G. and Koutcher, J. A.},\n title = {Dynamic contrast-enhanced magnetic resonance imaging as a predictor of outcome in head-and-neck squamous cell carcinoma patients with nodal metastases},\n journal = {Int J Radiat Oncol Biol Phys},\n volume = {82},\n number = {5},\n pages = {1837-44},\n note = {Shukla-Dave, Amita\nLee, Nancy Y\nJansen, Jacobus F A\nThaler, Howard T\nStambuk, Hilda E\nFury, Matthew G\nPatel, Snehal G\nMoreira, Andre L\nSherman, Eric\nKarimi, Sasan\nWang, Ya\nKraus, Dennis\nShah, Jatin P\nPfister, David G\nKoutcher, Jason A\neng\nR01 CA115895/CA/NCI NIH HHS/\nR01 CA115895-05/CA/NCI NIH HHS/\n1 R01 CA115895/CA/NCI NIH HHS/\nResearch Support, N.I.H., Extramural\n2011/05/24 06:00\nInt J Radiat Oncol Biol Phys. 2012 Apr 1;82(5):1837-44. doi: 10.1016/j.ijrobp.2011.03.006. Epub 2011 May 19.},\n abstract = {PURPOSE: Dynamic contrast-enhanced MRI (DCE-MRI) can provide information regarding tumor perfusion and permeability and has shown prognostic value in certain tumors types. The goal of this study was to assess the prognostic value of pretreatment DCE-MRI in head and neck squamous cell carcinoma (HNSCC) patients with nodal disease undergoing chemoradiation therapy or surgery. METHODS AND MATERIALS: Seventy-four patients with histologically proven squamous cell carcinoma and neck nodal metastases were eligible for the study. Pretreatment DCE-MRI was performed on a 1.5T MRI. Clinical follow-up was a minimum of 12 months. DCE-MRI data were analyzed using the Tofts model. DCE-MRI parameters were related to treatment outcome (progression-free survival [PFS] and overall survival [OS]). Patients were grouped as no evidence of disease (NED), alive with disease (AWD), dead with disease (DOD), or dead of other causes (DOC). Prognostic significance was assessed using the log-rank test for single variables and Cox proportional hazards regression for combinations of variables. RESULTS: At last clinical follow-up, for Stage III, all 12 patients were NED. For Stage IV, 43 patients were NED, 4 were AWD, 11 were DOD, and 4 were DOC. K(trans) is volume transfer constant. In a stepwise Cox regression, skewness of K(trans) (volume transfer constant) was the strongest predictor for Stage IV patients (PFS and OS: p <0.001). CONCLUSION: Our study shows that skewness of K(trans) was the strongest predictor of PFS and OS in Stage IV HNSCC patients with nodal disease. This study suggests an important role for pretreatment DCE-MRI parameter K(trans) as a predictor of outcome in these patients.},\n keywords = {Adult\nAged\nAged, 80 and over\nAnalysis of Variance\nCarcinoma, Squamous Cell/*diagnosis/mortality/pathology/secondary/therapy\nChemoradiotherapy/methods\n*Contrast Media\nDisease-Free Survival\nFemale\nFollow-Up Studies\nGadolinium DTPA\nHumans\nLymphatic Metastasis\nMagnetic Resonance Imaging/*methods\nMale\nMiddle Aged\nMouth Neoplasms/*diagnosis/mortality/pathology/secondary/therapy\nNeoplasm Staging\nOropharyngeal Neoplasms/*diagnosis/mortality/pathology/secondary/therapy\nProportional Hazards Models\nRetrospective Studies\nStatistics, Nonparametric\nTreatment Outcome},\n ISSN = {1879-355X (Electronic)\n0360-3016 (Linking)},\n DOI = {10.1016/j.ijrobp.2011.03.006},\n url = {http://www.ncbi.nlm.nih.gov/pubmed/21601373\nhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177034/pdf/nihms299438.pdf},\n year = {2012},\n type = {Journal Article}\n}\n\n","author_short":["Shukla-Dave, A.","Lee, N. 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