The entry of nanoparticles into solid tumours. Sindhwani, S., Syed, A. M., Ngai, J., Kingston, B. R., Maiorino, L., Rothschild, J., MacMillan, P., Zhang, Y., Rajesh, N. U., Hoang, T., Wu, J. L. Y., Wilhelm, S., Zilman, A., Gadde, S., Sulaiman, A., Ouyang, B., Lin, Z., Wang, L., Egeblad, M., & Chan, W. C. W. Nat. Mater., 19(5):566–575, May, 2020. Bandiera_abtest: a Cg_type: Nature Research Journals Number: 5 Primary_atype: Research Publisher: Nature Publishing Group Subject_term: Cancer microenvironment;Imaging techniques;Nanoparticles;Nanotechnology in cancer Subject_term_id: cancer-microenvironment;imaging-techniques;nanoparticles;nanotechnology-in-cancer
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Paper Paper doi abstract bibtex 11 downloads The concept of nanoparticle transport through gaps between endothelial cells (inter-endothelial gaps) in the tumour blood vessel is a central paradigm in cancer nanomedicine. The size of these gaps was found to be up to 2,000 nm. This justified the development of nanoparticles to treat solid tumours as their size is small enough to extravasate and access the tumour microenvironment. Here we show that these inter-endothelial gaps are not responsible for the transport of nanoparticles into solid tumours. Instead, we found that up to 97% of nanoparticles enter tumours using an active process through endothelial cells. This result is derived from analysis of four different mouse models, three different types of human tumours, mathematical simulation and modelling, and two different types of imaging techniques. These results challenge our current rationale for developing cancer nanomedicine and suggest that understanding these active pathways will unlock strategies to enhance tumour accumulation.
@article{sindhwani_entry_2020,
title = {The entry of nanoparticles into solid tumours},
volume = {19},
copyright = {2020 The Author(s), under exclusive licence to Springer Nature Limited},
issn = {1476-4660},
url = {https://www.nature.com/articles/s41563-019-0566-2},
doi = {10.1038/s41563-019-0566-2},
abstract = {The concept of nanoparticle transport through gaps between endothelial cells (inter-endothelial gaps) in the tumour blood vessel is a central paradigm in cancer nanomedicine. The size of these gaps was found to be up to 2,000 nm. This justified the development of nanoparticles to treat solid tumours as their size is small enough to extravasate and access the tumour microenvironment. Here we show that these inter-endothelial gaps are not responsible for the transport of nanoparticles into solid tumours. Instead, we found that up to 97\% of nanoparticles enter tumours using an active process through endothelial cells. This result is derived from analysis of four different mouse models, three different types of human tumours, mathematical simulation and modelling, and two different types of imaging techniques. These results challenge our current rationale for developing cancer nanomedicine and suggest that understanding these active pathways will unlock strategies to enhance tumour accumulation.},
language = {en},
number = {5},
urldate = {2021-11-06},
journal = {Nat. Mater.},
author = {Sindhwani, Shrey and Syed, Abdullah Muhammad and Ngai, Jessica and Kingston, Benjamin R. and Maiorino, Laura and Rothschild, Jeremy and MacMillan, Presley and Zhang, Yuwei and Rajesh, Netra Unni and Hoang, Tran and Wu, Jamie L. Y. and Wilhelm, Stefan and Zilman, Anton and Gadde, Suresh and Sulaiman, Andrew and Ouyang, Ben and Lin, Zachary and Wang, Lisheng and Egeblad, Mikala and Chan, Warren C. W.},
month = may,
year = {2020},
note = {Bandiera\_abtest: a
Cg\_type: Nature Research Journals
Number: 5
Primary\_atype: Research
Publisher: Nature Publishing Group
Subject\_term: Cancer microenvironment;Imaging techniques;Nanoparticles;Nanotechnology in cancer
Subject\_term\_id: cancer-microenvironment;imaging-techniques;nanoparticles;nanotechnology-in-cancer},
keywords = {Cancer microenvironment, Imaging techniques, Nanoparticles, Nanotechnology in cancer},
pages = {566--575},
file = {Full Text PDF:files/1806/Sindhwani et al. - 2020 - The entry of nanoparticles into solid tumours.pdf:application/pdf;Snapshot:files/1808/s41563-019-0566-2.html:text/html},
url_Paper = {https://inbs.med.utoronto.ca/wp-content/uploads/2022/01/Sindhwani-et-al.-2020-The-entry-of-nanoparticles-into-solid-tumours.pdf}
}Downloads: 11
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