Global epidemiology of hip fractures: a study protocol using a common analytical platform among multiple countries. Sing, C. W., Lin, T. C., Bartholomew, S., Bell, J. S., Bennett, C., Beyene, K., Bosco-Lévy, P., Chan, A. H. Y., Chandran, M., Cheung, C. L., Doyon, C. Y., Droz-Perroteau, C., Ganesan, G., Hartikainen, S., Ilomaki, J., Jeong, H. E., Kiel, D. P., Kubota, K., Lai, E. C., Lange, J., Lewiecki, E. M., Liu, J., Man, K. K. C., Mendes de Abreu, M., Moore, N., O'Kelly, J., Ooba, N., Pedersen, A. B., Prieto-Alhambra, D., Shin, J. Y., Sørensen, H. T., Tan, K. B., Tolppanen, A. M., Verhamme, K. M. C., Wang, G. H., Watcharathanakij, S., Zhao, H., & Wong, I. C. K. BMJ Open, 11(7):e047258, 2021. 2044-6055 Sing, Chor-Wing Orcid: 0000-0002-2180-3676 Lin, Tzu-Chieh Bartholomew, Sharon Bell, J Simon Bennett, Corina Beyene, Kebede Bosco-Lévy, Pauline Chan, Amy Hai Yan Chandran, Manju Cheung, Ching-Lung Doyon, Caroline Y Droz-Perroteau, Cécile Ganesan, Ganga Hartikainen, Sirpa Ilomaki, Jenni Jeong, Han Eol Kiel, Douglas P Kubota, Kiyoshi Lai, Edward Chia-Cheng Lange, Jeff Lewiecki, E Michael Liu, Jiannong Man, Kenneth K C Orcid: 0000-0001-8645-1942 Mendes de Abreu, Mirhelen Orcid: 0000-0002-2264-0442 Moore, Nicolas O'Kelly, James Ooba, Nobuhiro Pedersen, Alma B Prieto-Alhambra, Daniel Orcid: 0000-0002-3950-6346 Shin, Ju-Young Orcid: 0000-0002-2791-1037 Sørensen, Henrik T Tan, Kelvin Bryan Tolppanen, Anna-Maija Verhamme, Katia M C Orcid: 0000-0001-8162-4904 Wang, Grace Hsin-Min Watcharathanakij, Sawaeng Zhao, Hongxin Orcid: 0000-0001-7906-2797 Wong, Ian C K Journal Article Research Support, Non-U.S. Gov't England 2021/07/30 BMJ Open. 2021 Jul 28;11(7):e047258. doi: 10.1136/bmjopen-2020-047258.abstract bibtex INTRODUCTION: Hip fractures are associated with a high burden of morbidity and mortality. Globally, there is wide variation in the incidence of hip fracture in people aged 50 years and older. Longitudinal and cross-geographical comparisons of health data can provide insights on aetiology, risk factors, and healthcare practices. However, systematic reviews of studies that use different methods and study periods do not permit direct comparison across geographical regions. Thus, the objective of this study is to investigate global secular trends in hip fracture incidence, mortality and use of postfracture pharmacological treatment across Asia, Oceania, North and South America, and Western and Northern Europe using a unified methodology applied to health records. METHODS AND ANALYSIS: This retrospective cohort study will use a common protocol and an analytical common data model approach to examine incidence of hip fracture across population-based databases in different geographical regions and healthcare settings. The study period will be from 2005 to 2018 subject to data availability in study sites. Patients aged 50 years and older and hospitalised due to hip fracture during the study period will be included. The primary outcome will be expressed as the annual incidence of hip fracture. Secondary outcomes will be the pharmacological treatment rate and mortality within 12 months following initial hip fracture by year. For the primary outcome, crude and standardised incidence of hip fracture will be reported. Linear regression will be used to test for time trends in the annual incidence. For secondary outcomes, the crude mortality and standardised mortality incidence will be reported. ETHICS AND DISSEMINATION: Each participating site will follow the relevant local ethics and regulatory frameworks for study approval. The results of the study will be submitted for peer-reviewed scientific publications and presented at scientific conferences.
@article{RN414,
author = {Sing, C. W. and Lin, T. C. and Bartholomew, S. and Bell, J. S. and Bennett, C. and Beyene, K. and Bosco-Lévy, P. and Chan, A. H. Y. and Chandran, M. and Cheung, C. L. and Doyon, C. Y. and Droz-Perroteau, C. and Ganesan, G. and Hartikainen, S. and Ilomaki, J. and Jeong, H. E. and Kiel, D. P. and Kubota, K. and Lai, E. C. and Lange, J. and Lewiecki, E. M. and Liu, J. and Man, K. K. C. and Mendes de Abreu, M. and Moore, N. and O'Kelly, J. and Ooba, N. and Pedersen, A. B. and Prieto-Alhambra, D. and Shin, J. Y. and Sørensen, H. T. and Tan, K. B. and Tolppanen, A. M. and Verhamme, K. M. C. and Wang, G. H. and Watcharathanakij, S. and Zhao, H. and Wong, I. C. K.},
title = {Global epidemiology of hip fractures: a study protocol using a common analytical platform among multiple countries},
journal = {BMJ Open},
volume = {11},
number = {7},
pages = {e047258},
note = {2044-6055 Sing, Chor-Wing Orcid: 0000-0002-2180-3676 Lin, Tzu-Chieh Bartholomew, Sharon Bell, J Simon Bennett, Corina Beyene, Kebede Bosco-Lévy, Pauline Chan, Amy Hai Yan Chandran, Manju Cheung, Ching-Lung Doyon, Caroline Y Droz-Perroteau, Cécile Ganesan, Ganga Hartikainen, Sirpa Ilomaki, Jenni Jeong, Han Eol Kiel, Douglas P Kubota, Kiyoshi Lai, Edward Chia-Cheng Lange, Jeff Lewiecki, E Michael Liu, Jiannong Man, Kenneth K C Orcid: 0000-0001-8645-1942 Mendes de Abreu, Mirhelen Orcid: 0000-0002-2264-0442 Moore, Nicolas O'Kelly, James Ooba, Nobuhiro Pedersen, Alma B Prieto-Alhambra, Daniel Orcid: 0000-0002-3950-6346 Shin, Ju-Young Orcid: 0000-0002-2791-1037 Sørensen, Henrik T Tan, Kelvin Bryan Tolppanen, Anna-Maija Verhamme, Katia M C Orcid: 0000-0001-8162-4904 Wang, Grace Hsin-Min Watcharathanakij, Sawaeng Zhao, Hongxin Orcid: 0000-0001-7906-2797 Wong, Ian C K Journal Article Research Support, Non-U.S. Gov't England 2021/07/30 BMJ Open. 2021 Jul 28;11(7):e047258. doi: 10.1136/bmjopen-2020-047258.},
abstract = {INTRODUCTION: Hip fractures are associated with a high burden of morbidity and mortality. Globally, there is wide variation in the incidence of hip fracture in people aged 50 years and older. Longitudinal and cross-geographical comparisons of health data can provide insights on aetiology, risk factors, and healthcare practices. However, systematic reviews of studies that use different methods and study periods do not permit direct comparison across geographical regions. Thus, the objective of this study is to investigate global secular trends in hip fracture incidence, mortality and use of postfracture pharmacological treatment across Asia, Oceania, North and South America, and Western and Northern Europe using a unified methodology applied to health records. METHODS AND ANALYSIS: This retrospective cohort study will use a common protocol and an analytical common data model approach to examine incidence of hip fracture across population-based databases in different geographical regions and healthcare settings. The study period will be from 2005 to 2018 subject to data availability in study sites. Patients aged 50 years and older and hospitalised due to hip fracture during the study period will be included. The primary outcome will be expressed as the annual incidence of hip fracture. Secondary outcomes will be the pharmacological treatment rate and mortality within 12 months following initial hip fracture by year. For the primary outcome, crude and standardised incidence of hip fracture will be reported. Linear regression will be used to test for time trends in the annual incidence. For secondary outcomes, the crude mortality and standardised mortality incidence will be reported. ETHICS AND DISSEMINATION: Each participating site will follow the relevant local ethics and regulatory frameworks for study approval. The results of the study will be submitted for peer-reviewed scientific publications and presented at scientific conferences.},
keywords = {Aged
Asia
Europe
*Hip Fractures/epidemiology
Humans
Incidence
Middle Aged
Retrospective Studies
South America
calcium & bone
diabetes & endocrinology
epidemiology
public health ,
ISSN = 2044-6055 ,
DOI = 10.1136/bmjopen-2020-047258},
year = {2021},
type = {Journal Article}
}
Downloads: 0
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K."],"bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Sing"],"firstnames":["C.","W."],"suffixes":[]},{"propositions":[],"lastnames":["Lin"],"firstnames":["T.","C."],"suffixes":[]},{"propositions":[],"lastnames":["Bartholomew"],"firstnames":["S."],"suffixes":[]},{"propositions":[],"lastnames":["Bell"],"firstnames":["J.","S."],"suffixes":[]},{"propositions":[],"lastnames":["Bennett"],"firstnames":["C."],"suffixes":[]},{"propositions":[],"lastnames":["Beyene"],"firstnames":["K."],"suffixes":[]},{"propositions":[],"lastnames":["Bosco-Lévy"],"firstnames":["P."],"suffixes":[]},{"propositions":[],"lastnames":["Chan"],"firstnames":["A.","H.","Y."],"suffixes":[]},{"propositions":[],"lastnames":["Chandran"],"firstnames":["M."],"suffixes":[]},{"propositions":[],"lastnames":["Cheung"],"firstnames":["C.","L."],"suffixes":[]},{"propositions":[],"lastnames":["Doyon"],"firstnames":["C.","Y."],"suffixes":[]},{"propositions":[],"lastnames":["Droz-Perroteau"],"firstnames":["C."],"suffixes":[]},{"propositions":[],"lastnames":["Ganesan"],"firstnames":["G."],"suffixes":[]},{"propositions":[],"lastnames":["Hartikainen"],"firstnames":["S."],"suffixes":[]},{"propositions":[],"lastnames":["Ilomaki"],"firstnames":["J."],"suffixes":[]},{"propositions":[],"lastnames":["Jeong"],"firstnames":["H.","E."],"suffixes":[]},{"propositions":[],"lastnames":["Kiel"],"firstnames":["D.","P."],"suffixes":[]},{"propositions":[],"lastnames":["Kubota"],"firstnames":["K."],"suffixes":[]},{"propositions":[],"lastnames":["Lai"],"firstnames":["E.","C."],"suffixes":[]},{"propositions":[],"lastnames":["Lange"],"firstnames":["J."],"suffixes":[]},{"propositions":[],"lastnames":["Lewiecki"],"firstnames":["E.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Liu"],"firstnames":["J."],"suffixes":[]},{"propositions":[],"lastnames":["Man"],"firstnames":["K.","K.","C."],"suffixes":[]},{"propositions":["Mendes","de"],"lastnames":["Abreu"],"firstnames":["M."],"suffixes":[]},{"propositions":[],"lastnames":["Moore"],"firstnames":["N."],"suffixes":[]},{"propositions":[],"lastnames":["O'Kelly"],"firstnames":["J."],"suffixes":[]},{"propositions":[],"lastnames":["Ooba"],"firstnames":["N."],"suffixes":[]},{"propositions":[],"lastnames":["Pedersen"],"firstnames":["A.","B."],"suffixes":[]},{"propositions":[],"lastnames":["Prieto-Alhambra"],"firstnames":["D."],"suffixes":[]},{"propositions":[],"lastnames":["Shin"],"firstnames":["J.","Y."],"suffixes":[]},{"propositions":[],"lastnames":["Sørensen"],"firstnames":["H.","T."],"suffixes":[]},{"propositions":[],"lastnames":["Tan"],"firstnames":["K.","B."],"suffixes":[]},{"propositions":[],"lastnames":["Tolppanen"],"firstnames":["A.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Verhamme"],"firstnames":["K.","M.","C."],"suffixes":[]},{"propositions":[],"lastnames":["Wang"],"firstnames":["G.","H."],"suffixes":[]},{"propositions":[],"lastnames":["Watcharathanakij"],"firstnames":["S."],"suffixes":[]},{"propositions":[],"lastnames":["Zhao"],"firstnames":["H."],"suffixes":[]},{"propositions":[],"lastnames":["Wong"],"firstnames":["I.","C.","K."],"suffixes":[]}],"title":"Global epidemiology of hip fractures: a study protocol using a common analytical platform among multiple countries","journal":"BMJ Open","volume":"11","number":"7","pages":"e047258","note":"2044-6055 Sing, Chor-Wing Orcid: 0000-0002-2180-3676 Lin, Tzu-Chieh Bartholomew, Sharon Bell, J Simon Bennett, Corina Beyene, Kebede Bosco-Lévy, Pauline Chan, Amy Hai Yan Chandran, Manju Cheung, Ching-Lung Doyon, Caroline Y Droz-Perroteau, Cécile Ganesan, Ganga Hartikainen, Sirpa Ilomaki, Jenni Jeong, Han Eol Kiel, Douglas P Kubota, Kiyoshi Lai, Edward Chia-Cheng Lange, Jeff Lewiecki, E Michael Liu, Jiannong Man, Kenneth K C Orcid: 0000-0001-8645-1942 Mendes de Abreu, Mirhelen Orcid: 0000-0002-2264-0442 Moore, Nicolas O'Kelly, James Ooba, Nobuhiro Pedersen, Alma B Prieto-Alhambra, Daniel Orcid: 0000-0002-3950-6346 Shin, Ju-Young Orcid: 0000-0002-2791-1037 Sørensen, Henrik T Tan, Kelvin Bryan Tolppanen, Anna-Maija Verhamme, Katia M C Orcid: 0000-0001-8162-4904 Wang, Grace Hsin-Min Watcharathanakij, Sawaeng Zhao, Hongxin Orcid: 0000-0001-7906-2797 Wong, Ian C K Journal Article Research Support, Non-U.S. Gov't England 2021/07/30 BMJ Open. 2021 Jul 28;11(7):e047258. doi: 10.1136/bmjopen-2020-047258.","abstract":"INTRODUCTION: Hip fractures are associated with a high burden of morbidity and mortality. Globally, there is wide variation in the incidence of hip fracture in people aged 50 years and older. Longitudinal and cross-geographical comparisons of health data can provide insights on aetiology, risk factors, and healthcare practices. However, systematic reviews of studies that use different methods and study periods do not permit direct comparison across geographical regions. Thus, the objective of this study is to investigate global secular trends in hip fracture incidence, mortality and use of postfracture pharmacological treatment across Asia, Oceania, North and South America, and Western and Northern Europe using a unified methodology applied to health records. METHODS AND ANALYSIS: This retrospective cohort study will use a common protocol and an analytical common data model approach to examine incidence of hip fracture across population-based databases in different geographical regions and healthcare settings. The study period will be from 2005 to 2018 subject to data availability in study sites. Patients aged 50 years and older and hospitalised due to hip fracture during the study period will be included. The primary outcome will be expressed as the annual incidence of hip fracture. Secondary outcomes will be the pharmacological treatment rate and mortality within 12 months following initial hip fracture by year. For the primary outcome, crude and standardised incidence of hip fracture will be reported. Linear regression will be used to test for time trends in the annual incidence. For secondary outcomes, the crude mortality and standardised mortality incidence will be reported. ETHICS AND DISSEMINATION: Each participating site will follow the relevant local ethics and regulatory frameworks for study approval. The results of the study will be submitted for peer-reviewed scientific publications and presented at scientific conferences.","keywords":"Aged Asia Europe *Hip Fractures/epidemiology Humans Incidence Middle Aged Retrospective Studies South America calcium & bone diabetes & endocrinology epidemiology public health , ISSN = 2044-6055 , DOI = 10.1136/bmjopen-2020-047258","year":"2021","bibtex":"@article{RN414,\r\n author = {Sing, C. W. and Lin, T. C. and Bartholomew, S. and Bell, J. S. and Bennett, C. and Beyene, K. and Bosco-Lévy, P. and Chan, A. H. Y. and Chandran, M. and Cheung, C. L. and Doyon, C. Y. and Droz-Perroteau, C. and Ganesan, G. and Hartikainen, S. and Ilomaki, J. and Jeong, H. E. and Kiel, D. P. and Kubota, K. and Lai, E. C. and Lange, J. and Lewiecki, E. M. and Liu, J. and Man, K. K. C. and Mendes de Abreu, M. and Moore, N. and O'Kelly, J. and Ooba, N. and Pedersen, A. B. and Prieto-Alhambra, D. and Shin, J. Y. and Sørensen, H. T. and Tan, K. B. and Tolppanen, A. M. and Verhamme, K. M. C. and Wang, G. H. and Watcharathanakij, S. and Zhao, H. and Wong, I. C. K.},\r\n title = {Global epidemiology of hip fractures: a study protocol using a common analytical platform among multiple countries},\r\n journal = {BMJ Open},\r\n volume = {11},\r\n number = {7},\r\n pages = {e047258},\r\n note = {2044-6055 Sing, Chor-Wing Orcid: 0000-0002-2180-3676 Lin, Tzu-Chieh Bartholomew, Sharon Bell, J Simon Bennett, Corina Beyene, Kebede Bosco-Lévy, Pauline Chan, Amy Hai Yan Chandran, Manju Cheung, Ching-Lung Doyon, Caroline Y Droz-Perroteau, Cécile Ganesan, Ganga Hartikainen, Sirpa Ilomaki, Jenni Jeong, Han Eol Kiel, Douglas P Kubota, Kiyoshi Lai, Edward Chia-Cheng Lange, Jeff Lewiecki, E Michael Liu, Jiannong Man, Kenneth K C Orcid: 0000-0001-8645-1942 Mendes de Abreu, Mirhelen Orcid: 0000-0002-2264-0442 Moore, Nicolas O'Kelly, James Ooba, Nobuhiro Pedersen, Alma B Prieto-Alhambra, Daniel Orcid: 0000-0002-3950-6346 Shin, Ju-Young Orcid: 0000-0002-2791-1037 Sørensen, Henrik T Tan, Kelvin Bryan Tolppanen, Anna-Maija Verhamme, Katia M C Orcid: 0000-0001-8162-4904 Wang, Grace Hsin-Min Watcharathanakij, Sawaeng Zhao, Hongxin Orcid: 0000-0001-7906-2797 Wong, Ian C K Journal Article Research Support, Non-U.S. Gov't England 2021/07/30 BMJ Open. 2021 Jul 28;11(7):e047258. doi: 10.1136/bmjopen-2020-047258.},\r\n abstract = {INTRODUCTION: Hip fractures are associated with a high burden of morbidity and mortality. 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The study period will be from 2005 to 2018 subject to data availability in study sites. Patients aged 50 years and older and hospitalised due to hip fracture during the study period will be included. The primary outcome will be expressed as the annual incidence of hip fracture. Secondary outcomes will be the pharmacological treatment rate and mortality within 12 months following initial hip fracture by year. For the primary outcome, crude and standardised incidence of hip fracture will be reported. Linear regression will be used to test for time trends in the annual incidence. For secondary outcomes, the crude mortality and standardised mortality incidence will be reported. ETHICS AND DISSEMINATION: Each participating site will follow the relevant local ethics and regulatory frameworks for study approval. 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