Molecular epidemiology and diversity of SARS-CoV-2 in Ethiopia, 2020-2022. Sisay, A., Tshiabuila, D., van Wyk, S., Tesfaye, A., Mboowa, G., Oyola, S. O, Tesema, S. K., Baxter, C., Martin, D., Lessells, R., Tegally, H., Moir, M., Giandhari, J., Pillay, S., Singh, L., Ramphal, Y., Maharaj, A., Pillay, Y., Maharaj, A., Naidoo, Y., Ramphal, U., Chabuka, L., Wilkinson, E., de Oliveira, T., Desta, A. F., & San, J. E Genes, 14(3):705, Multidisciplinary Digital Publishing Institute, mar, 2023. ![Molecular epidemiology and diversity of SARS-CoV-2 in Ethiopia, 2020-2022 [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Ethiopia is the second most populous country in Africa and the sixth most affected by COVID-19 on the continent. Despite having experienced five infection waves, \textgreater499,000 cases, and \ 7500 COVID-19-related deaths as of January 2023, there is still no detailed genomic epidemiological report on the introduction and spread of SARS-CoV-2 in Ethiopia. In this study, we reconstructed and elucidated the COVID-19 epidemic dynamics. Specifically, we investigated the introduction, local transmission, ongoing evolution, and spread of SARS-CoV-2 during the first four infection waves using 353 high-quality near-whole genomes sampled in Ethiopia. Our results show that whereas viral introductions seeded the first wave, subsequent waves were seeded by local transmission. The B.1.480 lineage emerged in the first wave and notably remained in circulation even after the emergence of the Alpha variant. The B.1.480 was outcompeted by the Delta variant. Notably, Ethiopia’s lack of local sequencing capacity was further limited by sporadic, uneven, and insufficient sampling that limited the incorporation of genomic epidemiology in the epidemic public health response in Ethiopia. These results highlight Ethiopia’s role in SARS-CoV-2 dissemination and the urgent need for balanced, near-real-time genomic sequencing.
@article{Sisay2023,
abstract = {Ethiopia is the second most populous country in Africa and the sixth most affected by COVID-19 on the continent. Despite having experienced five infection waves, {\textgreater}499,000 cases, and {\~{}}7500 COVID-19-related deaths as of January 2023, there is still no detailed genomic epidemiological report on the introduction and spread of SARS-CoV-2 in Ethiopia. In this study, we reconstructed and elucidated the COVID-19 epidemic dynamics. Specifically, we investigated the introduction, local transmission, ongoing evolution, and spread of SARS-CoV-2 during the first four infection waves using 353 high-quality near-whole genomes sampled in Ethiopia. Our results show that whereas viral introductions seeded the first wave, subsequent waves were seeded by local transmission. The B.1.480 lineage emerged in the first wave and notably remained in circulation even after the emergence of the Alpha variant. The B.1.480 was outcompeted by the Delta variant. Notably, Ethiopia{\&}rsquo;s lack of local sequencing capacity was further limited by sporadic, uneven, and insufficient sampling that limited the incorporation of genomic epidemiology in the epidemic public health response in Ethiopia. These results highlight Ethiopia{\&}rsquo;s role in SARS-CoV-2 dissemination and the urgent need for balanced, near-real-time genomic sequencing.},
author = {Sisay, Abay and Tshiabuila, Derek and van Wyk, Stephanie and Tesfaye, Abraham and Mboowa, Gerald and Oyola, Samuel O and Tesema, Sofonias Kifle and Baxter, Cheryl and Martin, Darren and Lessells, Richard and Tegally, Houriiyah and Moir, Monika and Giandhari, Jennifer and Pillay, Sureshnee and Singh, Lavanya and Ramphal, Yajna and Maharaj, Arisha and Pillay, Yusasha and Maharaj, Akhil and Naidoo, Yeshnee and Ramphal, Upasana and Chabuka, Lucious and Wilkinson, Eduan and de Oliveira, Tulio and Desta, Adey Feleke and San, James E},
doi = {10.3390/GENES14030705},
file = {:C$\backslash$:/Users/01462563/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Sisay et al. - 2023 - Molecular epidemiology and diversity of SARS-CoV-2 in Ethiopia, 2020-2022.pdf:pdf},
isbn = {3070900100},
issn = {2073-4425},
journal = {Genes},
keywords = {19,2,COVID,CoV,Ethiopia,OA,OA{\_}PMC,SARS,fund{\_}not{\_}ack,molecular epidemiology,original,whole genome sequence},
mendeley-tags = {OA,OA{\_}PMC,fund{\_}not{\_}ack,original},
month = {mar},
number = {3},
pages = {705},
pmid = {36980977},
publisher = {Multidisciplinary Digital Publishing Institute},
title = {{Molecular epidemiology and diversity of SARS-CoV-2 in Ethiopia, 2020-2022}},
url = {https://www.mdpi.com/2073-4425/14/3/705/htm https://www.mdpi.com/2073-4425/14/3/705},
volume = {14},
year = {2023}
}
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