Evidence for periaqueductal cholecystokinin-substance P neurons projecting to the spinal cord. Skirboll, L, Hokfelt, T, Dockray, G, Rehfeld, J, Brownstein, M, & Cuello, A. The Journal of Neuroscience, 3(6):1151, June, 1983. PMC6564612
Evidence for periaqueductal cholecystokinin-substance P neurons projecting to the spinal cord [link]Paper  doi  abstract   bibtex   
Using indirect immunofluorescence techniques combined with retrogradely transported fluorescent dyes, cholecystokinin (CCK)-like and substance P immunoreactive cell bodies in the periaqueductal central grey of the rat brain were studied. Data from both adjacent sections and elution- restaining techniques indicated that some of these central grey cells contain both a CCK-like peptide and substance P. Injection of the fluorescent dye, Fast Blue, into the cervical spinal cord indicated that this CCK-substance P cell group is a descending system. These findings provide evidence for two peptides in a single neuron, and the possible functional significance of such an occurrence is discussed.
@article{skirboll_evidence_1983,
	title = {Evidence for periaqueductal cholecystokinin-substance {P} neurons projecting to the spinal cord},
	volume = {3},
	url = {http://www.jneurosci.org/content/3/6/1151.abstract},
	doi = {10.1523/JNEUROSCI.03-06-01151.1983},
	abstract = {Using indirect immunofluorescence techniques combined with retrogradely transported fluorescent dyes, cholecystokinin (CCK)-like and substance P immunoreactive cell bodies in the periaqueductal central grey of the rat brain were studied. Data from both adjacent sections and elution- restaining techniques indicated that some of these central grey cells contain both a CCK-like peptide and substance P. Injection of the fluorescent dye, Fast Blue, into the cervical spinal cord indicated that this CCK-substance P cell group is a descending system. These findings provide evidence for two peptides in a single neuron, and the possible functional significance of such an occurrence is discussed.},
	number = {6},
	journal = {The Journal of Neuroscience},
	author = {Skirboll, L and Hokfelt, T and Dockray, G and Rehfeld, J and Brownstein, M and Cuello, AC},
	month = jun,
	year = {1983},
	note = {PMC6564612},
	keywords = {cholecystokinin, periaqueductal grey, spinal cord, substance P},
	pages = {1151},
}

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