@article{RN364,
   author = {Slegers, R. and Wagner, L. and van Kuijk, S. and Hilkman, D. and Hofman, P. and van Hoof, R. and Jansen, J. and van Kranen-Mastenbroek, V. and Rijkers, K. and Tousseyn, S. and Colon, A. and Schijns, O. and group, A. C. E. epilepsy surgery},
   title = {Stereo-electroencephalography-guided radiofrequency thermocoagulation restricted to periventricular nodular heterotopias in patients with drug-resistant epilepsy: A single center experience},
   journal = {Seizure},
   volume = {121},
   pages = {105-113},
   note = {Slegers, Rutger
Wagner, Louis
van Kuijk, Sander
Hilkman, Danny
Hofman, Paul
van Hoof, Raf
Jansen, Jacobus
van Kranen-Mastenbroek, Vivianne
Rijkers, Kim
Tousseyn, Simon
Colon, Albert
Schijns, Olaf
eng
England
2024/08/16
Seizure. 2024 Aug 8;121:105-113. doi: 10.1016/j.seizure.2024.07.016.},
   abstract = {INTRODUCTION: Periventricular nodular heterotopias (PVNH) are developmental abnormalities with neurons abnormally clustered around the cerebral ventricles. Patients frequently present with focal drug-resistant epilepsy (DRE). However, the relationship between PVNH and the seizure onset zone (SOZ) is complex. Stereo-electroencephalography (SEEG) is an invasive diagnostic procedure for patients with DRE. In selected patients, the SEEG may be converted into a therapeutic procedure, lesioning the probable (SOZ) with pulsed radiofrequency thermocoagulation (RFTC). The aim of our study was to evaluate the efficacy and safety of SEEG-RFTC in a series of DRE patients with PVNH. METHODS: Twenty-four patients with focal DRE related to PVNH and treated with SEEG-guided-RFTC restricted to nodules were prospectively collected between 2016 and 2023 and retrospectively analyzed after a follow-up of at least 12 months. RESULTS: Seventeen patients (71 %) responded (ILAE class 1-4) after SEEG-guided RFTC of whom eleven (46 %) became seizure-free (class 1) at last follow up, nine (45 %) despite residual PVNH tissue on MRI. SEEG seizure onset was restricted to PVNH in eleven patients (class 1 in 45 %) and simultaneously in PVNH and other cortical areas in thirteen patients (class 1 in 46 %). Out of 31 SEEG-RFTC procedures in twenty-four patients, adverse events, related to RFTC, were recorded in eight (26 %), of which two patients (8 %) had predicted permanent visual complaints whilst the other five had transient complaints. SIGNIFICANCE: This study demonstrates that a considerable percentage of patients, even with bilateral, multiple PVNH and involvement of adjacent cortical regions can be rendered seizure-free with SEEG-guided-RFTC restricted to the nodules. Furthermore, this study delivers evidence that the complete destruction of the entire nodule is not necessary to render a patient seizure free. This justifies the use of SEEG in patients with single, multiple or bilateral PVNHs to provide insight into the epileptogenic organization in and around these lesions.},
   keywords = {Epilepsy surgery
Safety outcome
Seizure outcome
Stereotactic surgery},
   ISSN = {1532-2688 (Electronic)
1059-1311 (Linking)},
   DOI = {10.1016/j.seizure.2024.07.016},
   url = {https://www.ncbi.nlm.nih.gov/pubmed/39146706},
   year = {2024},
   type = {Journal Article}
}

{"_id":"po5Jj4danMshKfiHD","bibbaseid":"slegers-wagner-vankuijk-hilkman-hofman-vanhoof-jansen-vankranenmastenbroek-etal-stereoelectroencephalographyguidedradiofrequencythermocoagulationrestrictedtoperiventricularnodularheterotopiasinpatientswithdrugresistantepilepsyasinglecenterexperience-2024","author_short":["Slegers, R.","Wagner, L.","van Kuijk, S.","Hilkman, D.","Hofman, P.","van Hoof, R.","Jansen, J.","van Kranen-Mastenbroek, V.","Rijkers, K.","Tousseyn, S.","Colon, A.","Schijns, O.","group , A. C. E. e. s."],"bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Slegers"],"firstnames":["R."],"suffixes":[]},{"propositions":[],"lastnames":["Wagner"],"firstnames":["L."],"suffixes":[]},{"propositions":["van"],"lastnames":["Kuijk"],"firstnames":["S."],"suffixes":[]},{"propositions":[],"lastnames":["Hilkman"],"firstnames":["D."],"suffixes":[]},{"propositions":[],"lastnames":["Hofman"],"firstnames":["P."],"suffixes":[]},{"propositions":["van"],"lastnames":["Hoof"],"firstnames":["R."],"suffixes":[]},{"propositions":[],"lastnames":["Jansen"],"firstnames":["J."],"suffixes":[]},{"propositions":["van"],"lastnames":["Kranen-Mastenbroek"],"firstnames":["V."],"suffixes":[]},{"propositions":[],"lastnames":["Rijkers"],"firstnames":["K."],"suffixes":[]},{"propositions":[],"lastnames":["Tousseyn"],"firstnames":["S."],"suffixes":[]},{"propositions":[],"lastnames":["Colon"],"firstnames":["A."],"suffixes":[]},{"propositions":[],"lastnames":["Schijns"],"firstnames":["O."],"suffixes":[]},{"propositions":["group"],"lastnames":[],"firstnames":["A.","C.","E.","epilepsy","surgery"],"suffixes":[]}],"title":"Stereo-electroencephalography-guided radiofrequency thermocoagulation restricted to periventricular nodular heterotopias in patients with drug-resistant epilepsy: A single center experience","journal":"Seizure","volume":"121","pages":"105-113","note":"Slegers, Rutger Wagner, Louis van Kuijk, Sander Hilkman, Danny Hofman, Paul van Hoof, Raf Jansen, Jacobus van Kranen-Mastenbroek, Vivianne Rijkers, Kim Tousseyn, Simon Colon, Albert Schijns, Olaf eng England 2024/08/16 Seizure. 2024 Aug 8;121:105-113. doi: 10.1016/j.seizure.2024.07.016.","abstract":"INTRODUCTION: Periventricular nodular heterotopias (PVNH) are developmental abnormalities with neurons abnormally clustered around the cerebral ventricles. Patients frequently present with focal drug-resistant epilepsy (DRE). However, the relationship between PVNH and the seizure onset zone (SOZ) is complex. Stereo-electroencephalography (SEEG) is an invasive diagnostic procedure for patients with DRE. In selected patients, the SEEG may be converted into a therapeutic procedure, lesioning the probable (SOZ) with pulsed radiofrequency thermocoagulation (RFTC). The aim of our study was to evaluate the efficacy and safety of SEEG-RFTC in a series of DRE patients with PVNH. METHODS: Twenty-four patients with focal DRE related to PVNH and treated with SEEG-guided-RFTC restricted to nodules were prospectively collected between 2016 and 2023 and retrospectively analyzed after a follow-up of at least 12 months. RESULTS: Seventeen patients (71 %) responded (ILAE class 1-4) after SEEG-guided RFTC of whom eleven (46 %) became seizure-free (class 1) at last follow up, nine (45 %) despite residual PVNH tissue on MRI. SEEG seizure onset was restricted to PVNH in eleven patients (class 1 in 45 %) and simultaneously in PVNH and other cortical areas in thirteen patients (class 1 in 46 %). Out of 31 SEEG-RFTC procedures in twenty-four patients, adverse events, related to RFTC, were recorded in eight (26 %), of which two patients (8 %) had predicted permanent visual complaints whilst the other five had transient complaints. SIGNIFICANCE: This study demonstrates that a considerable percentage of patients, even with bilateral, multiple PVNH and involvement of adjacent cortical regions can be rendered seizure-free with SEEG-guided-RFTC restricted to the nodules. Furthermore, this study delivers evidence that the complete destruction of the entire nodule is not necessary to render a patient seizure free. This justifies the use of SEEG in patients with single, multiple or bilateral PVNHs to provide insight into the epileptogenic organization in and around these lesions.","keywords":"Epilepsy surgery Safety outcome Seizure outcome Stereotactic surgery","issn":"1532-2688 (Electronic) 1059-1311 (Linking)","doi":"10.1016/j.seizure.2024.07.016","url":"https://www.ncbi.nlm.nih.gov/pubmed/39146706","year":"2024","bibtex":"@article{RN364,\n author = {Slegers, R. and Wagner, L. and van Kuijk, S. and Hilkman, D. and Hofman, P. and van Hoof, R. and Jansen, J. and van Kranen-Mastenbroek, V. and Rijkers, K. and Tousseyn, S. and Colon, A. and Schijns, O. and group, A. C. E. epilepsy surgery},\n title = {Stereo-electroencephalography-guided radiofrequency thermocoagulation restricted to periventricular nodular heterotopias in patients with drug-resistant epilepsy: A single center experience},\n journal = {Seizure},\n volume = {121},\n pages = {105-113},\n note = {Slegers, Rutger\nWagner, Louis\nvan Kuijk, Sander\nHilkman, Danny\nHofman, Paul\nvan Hoof, Raf\nJansen, Jacobus\nvan Kranen-Mastenbroek, Vivianne\nRijkers, Kim\nTousseyn, Simon\nColon, Albert\nSchijns, Olaf\neng\nEngland\n2024/08/16\nSeizure. 2024 Aug 8;121:105-113. doi: 10.1016/j.seizure.2024.07.016.},\n abstract = {INTRODUCTION: Periventricular nodular heterotopias (PVNH) are developmental abnormalities with neurons abnormally clustered around the cerebral ventricles. Patients frequently present with focal drug-resistant epilepsy (DRE). However, the relationship between PVNH and the seizure onset zone (SOZ) is complex. Stereo-electroencephalography (SEEG) is an invasive diagnostic procedure for patients with DRE. In selected patients, the SEEG may be converted into a therapeutic procedure, lesioning the probable (SOZ) with pulsed radiofrequency thermocoagulation (RFTC). The aim of our study was to evaluate the efficacy and safety of SEEG-RFTC in a series of DRE patients with PVNH. METHODS: Twenty-four patients with focal DRE related to PVNH and treated with SEEG-guided-RFTC restricted to nodules were prospectively collected between 2016 and 2023 and retrospectively analyzed after a follow-up of at least 12 months. RESULTS: Seventeen patients (71 %) responded (ILAE class 1-4) after SEEG-guided RFTC of whom eleven (46 %) became seizure-free (class 1) at last follow up, nine (45 %) despite residual PVNH tissue on MRI. SEEG seizure onset was restricted to PVNH in eleven patients (class 1 in 45 %) and simultaneously in PVNH and other cortical areas in thirteen patients (class 1 in 46 %). Out of 31 SEEG-RFTC procedures in twenty-four patients, adverse events, related to RFTC, were recorded in eight (26 %), of which two patients (8 %) had predicted permanent visual complaints whilst the other five had transient complaints. SIGNIFICANCE: This study demonstrates that a considerable percentage of patients, even with bilateral, multiple PVNH and involvement of adjacent cortical regions can be rendered seizure-free with SEEG-guided-RFTC restricted to the nodules. Furthermore, this study delivers evidence that the complete destruction of the entire nodule is not necessary to render a patient seizure free. This justifies the use of SEEG in patients with single, multiple or bilateral PVNHs to provide insight into the epileptogenic organization in and around these lesions.},\n keywords = {Epilepsy surgery\nSafety outcome\nSeizure outcome\nStereotactic surgery},\n ISSN = {1532-2688 (Electronic)\n1059-1311 (Linking)},\n DOI = {10.1016/j.seizure.2024.07.016},\n url = {https://www.ncbi.nlm.nih.gov/pubmed/39146706},\n year = {2024},\n type = {Journal Article}\n}\n\n","author_short":["Slegers, R.","Wagner, L.","van Kuijk, S.","Hilkman, D.","Hofman, P.","van Hoof, R.","Jansen, J.","van Kranen-Mastenbroek, V.","Rijkers, K.","Tousseyn, S.","Colon, A.","Schijns, O.","group , A. C. E. e. s."],"key":"RN364","id":"RN364","bibbaseid":"slegers-wagner-vankuijk-hilkman-hofman-vanhoof-jansen-vankranenmastenbroek-etal-stereoelectroencephalographyguidedradiofrequencythermocoagulationrestrictedtoperiventricularnodularheterotopiasinpatientswithdrugresistantepilepsyasinglecenterexperience-2024","role":"author","urls":{"Paper":"https://www.ncbi.nlm.nih.gov/pubmed/39146706"},"keyword":["Epilepsy surgery Safety outcome Seizure outcome Stereotactic surgery"],"metadata":{"authorlinks":{}},"html":""},"bibtype":"article","biburl":"https://raw.githubusercontent.com/jansenjfa1/bibbase.github.io/master/jansenjfa.bib","dataSources":["TCkfRWJAZvbLAZi29"],"keywords":["epilepsy surgery safety outcome seizure outcome stereotactic surgery"],"search_terms":["stereo","electroencephalography","guided","radiofrequency","thermocoagulation","restricted","periventricular","nodular","heterotopias","patients","drug","resistant","epilepsy","single","center","experience","slegers","wagner","van kuijk","hilkman","hofman","van hoof","jansen","van kranen-mastenbroek","rijkers","tousseyn","colon","schijns","group "],"title":"Stereo-electroencephalography-guided radiofrequency thermocoagulation restricted to periventricular nodular heterotopias in patients with drug-resistant epilepsy: A single center experience","year":2024}