Reproductive outcomes among women exposed to a brominated flame retardant in utero. Small, C. M, Murray, D., Terrell, M. L, & Marcus, M. Archives of environmental & occupational health, 66(4):201–8, January, 2011. Paper doi abstract bibtex The authors studied 194 women exposed to polybrominated biphenyls (PBB) in utero when their mothers consumed products accidentally contaminated in Michigan in 1973. Generalized estimating equations were used to examine the effect of in utero PBB exposure on adult pregnancy-related outcomes. Compared to those with the lowest exposure (≤1 ppb), those with mid-range (\textgreater1-3.16 ppb) and high (≥3.17 ppb) PBB exposure had increased odds of spontaneous abortion with wide confidence intervals (odds ratio [OR] = 2.75, 95% confidence interval [CI] = 0.64-11.79, OR = 4.08, 95% CI = 0.94-17.70; respectively; p for trend = .05). Exposure during infancy to PBB-contaminated breast milk further increased this risk. Time to pregnancy and infertility were not associated with in utero exposure to PBB. Future studies should examine the suggested relationship between spontaneous abortion and other brominated flame retardants.
@article{small_reproductive_2011,
title = {Reproductive outcomes among women exposed to a brominated flame retardant in utero.},
volume = {66},
issn = {1933-8244},
url = {http://www.ncbi.nlm.nih.gov/pubmed/22014192},
doi = {10.1080/19338244.2010.539640},
abstract = {The authors studied 194 women exposed to polybrominated biphenyls (PBB) in utero when their mothers consumed products accidentally contaminated in Michigan in 1973. Generalized estimating equations were used to examine the effect of in utero PBB exposure on adult pregnancy-related outcomes. Compared to those with the lowest exposure (≤1 ppb), those with mid-range ({\textbackslash}textgreater1-3.16 ppb) and high (≥3.17 ppb) PBB exposure had increased odds of spontaneous abortion with wide confidence intervals (odds ratio [OR] = 2.75, 95\% confidence interval [CI] = 0.64-11.79, OR = 4.08, 95\% CI = 0.94-17.70; respectively; p for trend = .05). Exposure during infancy to PBB-contaminated breast milk further increased this risk. Time to pregnancy and infertility were not associated with in utero exposure to PBB. Future studies should examine the suggested relationship between spontaneous abortion and other brominated flame retardants.},
number = {4},
journal = {Archives of environmental \& occupational health},
author = {Small, Chanley M and Murray, Deanna and Terrell, Metrecia L and Marcus, Michele},
month = jan,
year = {2011},
pmid = {22014192},
keywords = {Abortion, Adolescent, Adult, Female, Fertility, Fertility: drug effects, Flame Retardants: adverse effects, Flame Retardants: analysis, Flame retardants, Food Contamination, Human, Human: chemistry, Humans, Infertility, Infertility: chemically induced, Infertility: epidemiology, Limit of Detection, Michigan, Milk, Polybrominated Biphenyls, Polybrominated Biphenyls: adverse effects, Polybrominated Biphenyls: analysis, Polybrominated Biphenyls: blood, Pregnancy, Pregnancy Outcome, Pregnancy Outcome: epidemiology, Prenatal Exposure Delayed Effects, Prenatal Exposure Delayed Effects: chemically indu, Spontaneous, Spontaneous: chemically induced, Spontaneous: epidemiology, Young Adult},
pages = {201--8},
}
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Compared to those with the lowest exposure (≤1 ppb), those with mid-range (\\textgreater1-3.16 ppb) and high (≥3.17 ppb) PBB exposure had increased odds of spontaneous abortion with wide confidence intervals (odds ratio [OR] = 2.75, 95% confidence interval [CI] = 0.64-11.79, OR = 4.08, 95% CI = 0.94-17.70; respectively; p for trend = .05). Exposure during infancy to PBB-contaminated breast milk further increased this risk. Time to pregnancy and infertility were not associated with in utero exposure to PBB. Future studies should examine the suggested relationship between spontaneous abortion and other brominated flame retardants.","number":"4","journal":"Archives of environmental & occupational health","author":[{"propositions":[],"lastnames":["Small"],"firstnames":["Chanley","M"],"suffixes":[]},{"propositions":[],"lastnames":["Murray"],"firstnames":["Deanna"],"suffixes":[]},{"propositions":[],"lastnames":["Terrell"],"firstnames":["Metrecia","L"],"suffixes":[]},{"propositions":[],"lastnames":["Marcus"],"firstnames":["Michele"],"suffixes":[]}],"month":"January","year":"2011","pmid":"22014192","keywords":"Abortion, Adolescent, Adult, Female, Fertility, Fertility: drug effects, Flame Retardants: adverse effects, Flame Retardants: analysis, Flame retardants, Food Contamination, Human, Human: chemistry, Humans, Infertility, Infertility: chemically induced, Infertility: epidemiology, Limit of Detection, Michigan, Milk, Polybrominated Biphenyls, Polybrominated Biphenyls: adverse effects, Polybrominated Biphenyls: analysis, Polybrominated Biphenyls: blood, Pregnancy, Pregnancy Outcome, Pregnancy Outcome: epidemiology, Prenatal Exposure Delayed Effects, Prenatal Exposure Delayed Effects: chemically indu, Spontaneous, Spontaneous: chemically induced, Spontaneous: epidemiology, Young Adult","pages":"201–8","bibtex":"@article{small_reproductive_2011,\n\ttitle = {Reproductive outcomes among women exposed to a brominated flame retardant in utero.},\n\tvolume = {66},\n\tissn = {1933-8244},\n\turl = {http://www.ncbi.nlm.nih.gov/pubmed/22014192},\n\tdoi = {10.1080/19338244.2010.539640},\n\tabstract = {The authors studied 194 women exposed to polybrominated biphenyls (PBB) in utero when their mothers consumed products accidentally contaminated in Michigan in 1973. 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