An Electrocardiographic Model of Myocardial Ischemia Injury. Smith, G., Geary, G., Blanchard, W., Roelofs, T., Ruf, W., & McNamara, J. j-JE, 16(3):223–234, 1983. bibtex @Article{RSM:Smi83b,
author = "G.T. Smith and G.G. Geary and W. Blanchard and T.H.
Roelofs and W. Ruf and J.J. McNamara",
title = "An Electrocardiographic Model of Myocardial Ischemia
Injury",
journal = j-JE,
year = "1983",
volume = "16",
number = "3",
pages = "223--234",
robnote = "In previous models of ischemia, the distribution and
amplitude of ST segment deflections are considered to
arise from a polarized surface interfacing normal and
ischemic myocardium. This concept in modeling ischemic
injury was derived from the application of principles
of electric field theory which had been successfully
applied previously to ventricular activation in which
QRS potentials are considered to arise from polarized
surfaces representing the relatively narrow interfaces
between depolarized and nondepolarized myocardium. The
present paper outlines the limitations of modeling
ischemic injury as a polarized surface in terms of the
failure of the predictions of such a model to be
supported by the experimentally observed: 1)
distribution and relative amplitude of epicardial ST
segment elevation overlying a region of ischemia; 2)
directional changes in epicardial ST segment elevation
that occur with changes in the size of an ischemic
region; and 3) nonuniform distribution of transmembrane
potential changes which occur within a region of
ischemia. A new electrocardiographic model of ischemic
injury is formulated which accounts for the nonuniform
distribution of transmembrane potential changes which
occur throughout a region of ischemia. The model
accurately describes experimental observations
regarding ST segment deflections which had remained
inconsistent with previous models.",
}
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