@Article{RSM:Smi83b,
  author =       "G.T. Smith and G.G. Geary and W. Blanchard and T.H.
                 Roelofs and W. Ruf and J.J. McNamara",
  title =        "An Electrocardiographic Model of Myocardial Ischemia
                 Injury",
  journal =      j-JE,
  year =         "1983",
  volume =       "16",
  number =       "3",
  pages =        "223--234",
  robnote =      "In previous models of ischemia, the distribution and
                 amplitude of ST segment deflections are considered to
                 arise from a polarized surface interfacing normal and
                 ischemic myocardium. This concept in modeling ischemic
                 injury was derived from the application of principles
                 of electric field theory which had been successfully
                 applied previously to ventricular activation in which
                 QRS potentials are considered to arise from polarized
                 surfaces representing the relatively narrow interfaces
                 between depolarized and nondepolarized myocardium. The
                 present paper outlines the limitations of modeling
                 ischemic injury as a polarized surface in terms of the
                 failure of the predictions of such a model to be
                 supported by the experimentally observed: 1)
                 distribution and relative amplitude of epicardial ST
                 segment elevation overlying a region of ischemia; 2)
                 directional changes in epicardial ST segment elevation
                 that occur with changes in the size of an ischemic
                 region; and 3) nonuniform distribution of transmembrane
                 potential changes which occur within a region of
                 ischemia. A new electrocardiographic model of ischemic
                 injury is formulated which accounts for the nonuniform
                 distribution of transmembrane potential changes which
                 occur throughout a region of ischemia. The model
                 accurately describes experimental observations
                 regarding ST segment deflections which had remained
                 inconsistent with previous models.",
}

{"_id":"MNTshmwrJkSRc9QfW","bibbaseid":"smith-geary-blanchard-roelofs-ruf-mcnamara-anelectrocardiographicmodelofmyocardialischemiainjury-1983","downloads":0,"creationDate":"2016-07-01T21:38:40.949Z","title":"An Electrocardiographic Model of Myocardial Ischemia Injury","author_short":["Smith, G.","Geary, G.","Blanchard, W.","Roelofs, T.","Ruf, W.","McNamara, J."],"year":1983,"bibtype":"article","biburl":"http://www.sci.utah.edu/~macleod/Bibtex/biglit.bib","bibdata":{"bibtype":"article","type":"article","author":[{"firstnames":["G.T."],"propositions":[],"lastnames":["Smith"],"suffixes":[]},{"firstnames":["G.G."],"propositions":[],"lastnames":["Geary"],"suffixes":[]},{"firstnames":["W."],"propositions":[],"lastnames":["Blanchard"],"suffixes":[]},{"firstnames":["T.H."],"propositions":[],"lastnames":["Roelofs"],"suffixes":[]},{"firstnames":["W."],"propositions":[],"lastnames":["Ruf"],"suffixes":[]},{"firstnames":["J.J."],"propositions":[],"lastnames":["McNamara"],"suffixes":[]}],"title":"An Electrocardiographic Model of Myocardial Ischemia Injury","journal":"j-JE","year":"1983","volume":"16","number":"3","pages":"223–234","robnote":"In previous models of ischemia, the distribution and amplitude of ST segment deflections are considered to arise from a polarized surface interfacing normal and ischemic myocardium. This concept in modeling ischemic injury was derived from the application of principles of electric field theory which had been successfully applied previously to ventricular activation in which QRS potentials are considered to arise from polarized surfaces representing the relatively narrow interfaces between depolarized and nondepolarized myocardium. The present paper outlines the limitations of modeling ischemic injury as a polarized surface in terms of the failure of the predictions of such a model to be supported by the experimentally observed: 1) distribution and relative amplitude of epicardial ST segment elevation overlying a region of ischemia; 2) directional changes in epicardial ST segment elevation that occur with changes in the size of an ischemic region; and 3) nonuniform distribution of transmembrane potential changes which occur within a region of ischemia. A new electrocardiographic model of ischemic injury is formulated which accounts for the nonuniform distribution of transmembrane potential changes which occur throughout a region of ischemia. The model accurately describes experimental observations regarding ST segment deflections which had remained inconsistent with previous models.","bibtex":"@Article{RSM:Smi83b,\n author = \"G.T. Smith and G.G. Geary and W. Blanchard and T.H.\n Roelofs and W. Ruf and J.J. McNamara\",\n title = \"An Electrocardiographic Model of Myocardial Ischemia\n Injury\",\n journal = j-JE,\n year = \"1983\",\n volume = \"16\",\n number = \"3\",\n pages = \"223--234\",\n robnote = \"In previous models of ischemia, the distribution and\n amplitude of ST segment deflections are considered to\n arise from a polarized surface interfacing normal and\n ischemic myocardium. This concept in modeling ischemic\n injury was derived from the application of principles\n of electric field theory which had been successfully\n applied previously to ventricular activation in which\n QRS potentials are considered to arise from polarized\n surfaces representing the relatively narrow interfaces\n between depolarized and nondepolarized myocardium. The\n present paper outlines the limitations of modeling\n ischemic injury as a polarized surface in terms of the\n failure of the predictions of such a model to be\n supported by the experimentally observed: 1)\n distribution and relative amplitude of epicardial ST\n segment elevation overlying a region of ischemia; 2)\n directional changes in epicardial ST segment elevation\n that occur with changes in the size of an ischemic\n region; and 3) nonuniform distribution of transmembrane\n potential changes which occur within a region of\n ischemia. A new electrocardiographic model of ischemic\n injury is formulated which accounts for the nonuniform\n distribution of transmembrane potential changes which\n occur throughout a region of ischemia. The model\n accurately describes experimental observations\n regarding ST segment deflections which had remained\n inconsistent with previous models.\",\n}\n\n","author_short":["Smith, G.","Geary, G.","Blanchard, W.","Roelofs, T.","Ruf, W.","McNamara, J."],"key":"RSM:Smi83b","id":"RSM:Smi83b","bibbaseid":"smith-geary-blanchard-roelofs-ruf-mcnamara-anelectrocardiographicmodelofmyocardialischemiainjury-1983","role":"author","urls":{},"metadata":{"authorlinks":{}},"downloads":0,"html":""},"search_terms":["electrocardiographic","model","myocardial","ischemia","injury","smith","geary","blanchard","roelofs","ruf","mcnamara"],"keywords":[],"authorIDs":[],"dataSources":["5HG3Kp8zRwDd7FotB"]}