Lack of neutralizing antibody response to HIV-1 predisposes to superinfection. Smith, D. M., Strain, M. C., Frost, S. D. W., Pillai, S. K., Wong, J. K., Wrin, T., Liu, Y., Petropolous, C. J., Daar, E. S., Little, S. J., & Richman, D. D. Virology, 355(1):1–5, November, 2006.
doi  abstract   bibtex   
Occurrences of HIV-1 superinfection offer a unique opportunity to investigate the correlates of immune protection. Here we describe the neutralizing antibody responses of a cohort of recently infected individuals who were screened for HIV superinfection. Three individuals identified with HIV superinfection had less cross-protective and autologous neutralizing antibody response than their non-superinfected case-controls. Neutralizing antibody may be crucial in the protection against superinfection and may explain why superinfection has only been documented following recent infection or treatment interruption. These data have considerable implications for vaccine development.
@article{smith_lack_2006,
	title = {Lack of neutralizing antibody response to {HIV}-1 predisposes to superinfection},
	volume = {355},
	issn = {0042-6822},
	doi = {10.1016/j.virol.2006.08.009},
	abstract = {Occurrences of HIV-1 superinfection offer a unique opportunity to investigate the correlates of immune protection. Here we describe the neutralizing antibody responses of a cohort of recently infected individuals who were screened for HIV superinfection. Three individuals identified with HIV superinfection had less cross-protective and autologous neutralizing antibody response than their non-superinfected case-controls. Neutralizing antibody may be crucial in the protection against superinfection and may explain why superinfection has only been documented following recent infection or treatment interruption. These data have considerable implications for vaccine development.},
	language = {eng},
	number = {1},
	journal = {Virology},
	author = {Smith, Davey M. and Strain, Matthew C. and Frost, Simon D. W. and Pillai, Satish K. and Wong, Joseph K. and Wrin, Terri and Liu, Yang and Petropolous, Christos J. and Daar, Eric S. and Little, Susan J. and Richman, Douglas D.},
	month = nov,
	year = {2006},
	pmid = {16962152},
	keywords = {Adult, Case-Control Studies, HIV Antibodies, HIV-1, Humans, Middle Aged, Neutralization Tests, Superinfection},
	pages = {1--5}
}

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