Pediatric Achalasia in the Netherlands: Incidence, Clinical Course, and Quality of Life. Smits, M., van Lennep, M., Vrijlandt, R., Benninga, M., Oors, J., Houwen, R., Kokke, F., van der Zee, D., Escher, J., van den Neucker, A., de Meij, T., Bodewes, F., Schweizer, J., Damen, G., Busch, O., & van Wijk, M. The Journal of Pediatrics, 169:110–115.e3, February, 2016. doi abstract bibtex OBJECTIVE: To assess incidence and clinical course of Dutch patients with achalasia diagnosed before 18 years of age as well as their current symptoms and quality of life (QoL). STUDY DESIGN: Retrospective medical chart review and a cross-sectional study assessing current clinical status using the Eckardt score and reflux disease questionnaire. General QoL was measured using Kidscreen-52 for patients \textless18 years of age or to 36-Item Short Form Health Survey for patients ≥18 years of age. RESULTS: Between 1990 and 2013, 87 children (mean age 11.4 ± 3.4 years, 60% male) diagnosed with achalasia in the Netherlands were included. Mean incidence was 0.1/100,000/y (range 0.03-0.21). Initial treatment was pneumodilation (PD) in 68 (79%) patients and Heller myotomy (HM) in 18 (21%) patients. Retreatment was required more often after initial PD compared with initial HM (88% vs 22%; P \textless .0001). More complications of initial treatment occurred after HM compared with PD (55.6% vs 1.5%; P \textless .0001). Three esophageal perforations were seen after HM (16.7%), 1 after PD (1.5%). Sixty-three of 87 (72%) patients were prospectively contacted. Median Eckardt score was 3 (IQR 2-5), with 32 patients (44.5%) having positive scores suggesting active disease. Reflux disease questionnaire scores were higher after initial HM vs PD (1.71 [0.96-2.90] vs 0.58 [0-1.56]; P = .005). The 36-Item Short Form Health Survey (n = 52) was lower compared with healthy population norms for 7/8 domains. Kidscreen-52 (n = 20) was similar to population norms. CONCLUSIONS: Pediatric achalasia is rare and relapse rates are high after initial treatment, especially after pneumodilation, but with more complications after HM. Symptoms often persist into adulthood, without any clinical follow-up. QoL in adulthood was decreased.
@article{smits_pediatric_2016,
title = {Pediatric {Achalasia} in the {Netherlands}: {Incidence}, {Clinical} {Course}, and {Quality} of {Life}},
volume = {169},
issn = {1097-6833},
shorttitle = {Pediatric {Achalasia} in the {Netherlands}},
doi = {10.1016/j.jpeds.2015.10.057},
abstract = {OBJECTIVE: To assess incidence and clinical course of Dutch patients with achalasia diagnosed before 18 years of age as well as their current symptoms and quality of life (QoL).
STUDY DESIGN: Retrospective medical chart review and a cross-sectional study assessing current clinical status using the Eckardt score and reflux disease questionnaire. General QoL was measured using Kidscreen-52 for patients {\textless}18 years of age or to 36-Item Short Form Health Survey for patients ≥18 years of age.
RESULTS: Between 1990 and 2013, 87 children (mean age 11.4 ± 3.4 years, 60\% male) diagnosed with achalasia in the Netherlands were included. Mean incidence was 0.1/100,000/y (range 0.03-0.21). Initial treatment was pneumodilation (PD) in 68 (79\%) patients and Heller myotomy (HM) in 18 (21\%) patients. Retreatment was required more often after initial PD compared with initial HM (88\% vs 22\%; P {\textless} .0001). More complications of initial treatment occurred after HM compared with PD (55.6\% vs 1.5\%; P {\textless} .0001). Three esophageal perforations were seen after HM (16.7\%), 1 after PD (1.5\%). Sixty-three of 87 (72\%) patients were prospectively contacted. Median Eckardt score was 3 (IQR 2-5), with 32 patients (44.5\%) having positive scores suggesting active disease. Reflux disease questionnaire scores were higher after initial HM vs PD (1.71 [0.96-2.90] vs 0.58 [0-1.56]; P = .005). The 36-Item Short Form Health Survey (n = 52) was lower compared with healthy population norms for 7/8 domains. Kidscreen-52 (n = 20) was similar to population norms.
CONCLUSIONS: Pediatric achalasia is rare and relapse rates are high after initial treatment, especially after pneumodilation, but with more complications after HM. Symptoms often persist into adulthood, without any clinical follow-up. QoL in adulthood was decreased.},
language = {eng},
journal = {The Journal of Pediatrics},
author = {Smits, Marije and van Lennep, Marinde and Vrijlandt, Remy and Benninga, Marc and Oors, Jac and Houwen, Roderick and Kokke, Freddy and van der Zee, David and Escher, Johanne and van den Neucker, Anita and de Meij, Tim and Bodewes, Frank and Schweizer, Joachim and Damen, Gerard and Busch, Olivier and van Wijk, Michiel},
month = feb,
year = {2016},
keywords = {Adolescent, Child, Cross-Sectional Studies, Esophageal Achalasia, Female, Humans, Incidence, Male, Netherlands, Quality of Life, Retrospective Studies},
pages = {110--115.e3},
}
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{"_id":"tmBbps2CGRgNNN7sz","bibbaseid":"smits-vanlennep-vrijlandt-benninga-oors-houwen-kokke-vanderzee-etal-pediatricachalasiainthenetherlandsincidenceclinicalcourseandqualityoflife-2016","author_short":["Smits, M.","van Lennep, M.","Vrijlandt, R.","Benninga, M.","Oors, J.","Houwen, R.","Kokke, F.","van der Zee, D.","Escher, J.","van den Neucker, A.","de Meij, T.","Bodewes, F.","Schweizer, J.","Damen, G.","Busch, O.","van Wijk, M."],"bibdata":{"bibtype":"article","type":"article","title":"Pediatric Achalasia in the Netherlands: Incidence, Clinical Course, and Quality of Life","volume":"169","issn":"1097-6833","shorttitle":"Pediatric Achalasia in the Netherlands","doi":"10.1016/j.jpeds.2015.10.057","abstract":"OBJECTIVE: To assess incidence and clinical course of Dutch patients with achalasia diagnosed before 18 years of age as well as their current symptoms and quality of life (QoL). STUDY DESIGN: Retrospective medical chart review and a cross-sectional study assessing current clinical status using the Eckardt score and reflux disease questionnaire. General QoL was measured using Kidscreen-52 for patients \\textless18 years of age or to 36-Item Short Form Health Survey for patients ≥18 years of age. RESULTS: Between 1990 and 2013, 87 children (mean age 11.4 ± 3.4 years, 60% male) diagnosed with achalasia in the Netherlands were included. Mean incidence was 0.1/100,000/y (range 0.03-0.21). Initial treatment was pneumodilation (PD) in 68 (79%) patients and Heller myotomy (HM) in 18 (21%) patients. Retreatment was required more often after initial PD compared with initial HM (88% vs 22%; P \\textless .0001). More complications of initial treatment occurred after HM compared with PD (55.6% vs 1.5%; P \\textless .0001). Three esophageal perforations were seen after HM (16.7%), 1 after PD (1.5%). Sixty-three of 87 (72%) patients were prospectively contacted. Median Eckardt score was 3 (IQR 2-5), with 32 patients (44.5%) having positive scores suggesting active disease. Reflux disease questionnaire scores were higher after initial HM vs PD (1.71 [0.96-2.90] vs 0.58 [0-1.56]; P = .005). The 36-Item Short Form Health Survey (n = 52) was lower compared with healthy population norms for 7/8 domains. Kidscreen-52 (n = 20) was similar to population norms. CONCLUSIONS: Pediatric achalasia is rare and relapse rates are high after initial treatment, especially after pneumodilation, but with more complications after HM. Symptoms often persist into adulthood, without any clinical follow-up. QoL in adulthood was decreased.","language":"eng","journal":"The Journal of Pediatrics","author":[{"propositions":[],"lastnames":["Smits"],"firstnames":["Marije"],"suffixes":[]},{"propositions":["van"],"lastnames":["Lennep"],"firstnames":["Marinde"],"suffixes":[]},{"propositions":[],"lastnames":["Vrijlandt"],"firstnames":["Remy"],"suffixes":[]},{"propositions":[],"lastnames":["Benninga"],"firstnames":["Marc"],"suffixes":[]},{"propositions":[],"lastnames":["Oors"],"firstnames":["Jac"],"suffixes":[]},{"propositions":[],"lastnames":["Houwen"],"firstnames":["Roderick"],"suffixes":[]},{"propositions":[],"lastnames":["Kokke"],"firstnames":["Freddy"],"suffixes":[]},{"propositions":["van","der"],"lastnames":["Zee"],"firstnames":["David"],"suffixes":[]},{"propositions":[],"lastnames":["Escher"],"firstnames":["Johanne"],"suffixes":[]},{"propositions":["van","den"],"lastnames":["Neucker"],"firstnames":["Anita"],"suffixes":[]},{"propositions":["de"],"lastnames":["Meij"],"firstnames":["Tim"],"suffixes":[]},{"propositions":[],"lastnames":["Bodewes"],"firstnames":["Frank"],"suffixes":[]},{"propositions":[],"lastnames":["Schweizer"],"firstnames":["Joachim"],"suffixes":[]},{"propositions":[],"lastnames":["Damen"],"firstnames":["Gerard"],"suffixes":[]},{"propositions":[],"lastnames":["Busch"],"firstnames":["Olivier"],"suffixes":[]},{"propositions":["van"],"lastnames":["Wijk"],"firstnames":["Michiel"],"suffixes":[]}],"month":"February","year":"2016","keywords":"Adolescent, Child, Cross-Sectional Studies, Esophageal Achalasia, Female, Humans, Incidence, Male, Netherlands, Quality of Life, Retrospective Studies","pages":"110–115.e3","bibtex":"@article{smits_pediatric_2016,\n\ttitle = {Pediatric {Achalasia} in the {Netherlands}: {Incidence}, {Clinical} {Course}, and {Quality} of {Life}},\n\tvolume = {169},\n\tissn = {1097-6833},\n\tshorttitle = {Pediatric {Achalasia} in the {Netherlands}},\n\tdoi = {10.1016/j.jpeds.2015.10.057},\n\tabstract = {OBJECTIVE: To assess incidence and clinical course of Dutch patients with achalasia diagnosed before 18 years of age as well as their current symptoms and quality of life (QoL).\nSTUDY DESIGN: Retrospective medical chart review and a cross-sectional study assessing current clinical status using the Eckardt score and reflux disease questionnaire. General QoL was measured using Kidscreen-52 for patients {\\textless}18 years of age or to 36-Item Short Form Health Survey for patients ≥18 years of age.\nRESULTS: Between 1990 and 2013, 87 children (mean age 11.4 ± 3.4 years, 60\\% male) diagnosed with achalasia in the Netherlands were included. Mean incidence was 0.1/100,000/y (range 0.03-0.21). Initial treatment was pneumodilation (PD) in 68 (79\\%) patients and Heller myotomy (HM) in 18 (21\\%) patients. Retreatment was required more often after initial PD compared with initial HM (88\\% vs 22\\%; P {\\textless} .0001). More complications of initial treatment occurred after HM compared with PD (55.6\\% vs 1.5\\%; P {\\textless} .0001). Three esophageal perforations were seen after HM (16.7\\%), 1 after PD (1.5\\%). Sixty-three of 87 (72\\%) patients were prospectively contacted. Median Eckardt score was 3 (IQR 2-5), with 32 patients (44.5\\%) having positive scores suggesting active disease. Reflux disease questionnaire scores were higher after initial HM vs PD (1.71 [0.96-2.90] vs 0.58 [0-1.56]; P = .005). The 36-Item Short Form Health Survey (n = 52) was lower compared with healthy population norms for 7/8 domains. Kidscreen-52 (n = 20) was similar to population norms.\nCONCLUSIONS: Pediatric achalasia is rare and relapse rates are high after initial treatment, especially after pneumodilation, but with more complications after HM. Symptoms often persist into adulthood, without any clinical follow-up. QoL in adulthood was decreased.},\n\tlanguage = {eng},\n\tjournal = {The Journal of Pediatrics},\n\tauthor = {Smits, Marije and van Lennep, Marinde and Vrijlandt, Remy and Benninga, Marc and Oors, Jac and Houwen, Roderick and Kokke, Freddy and van der Zee, David and Escher, Johanne and van den Neucker, Anita and de Meij, Tim and Bodewes, Frank and Schweizer, Joachim and Damen, Gerard and Busch, Olivier and van Wijk, Michiel},\n\tmonth = feb,\n\tyear = {2016},\n\tkeywords = {Adolescent, Child, Cross-Sectional Studies, Esophageal Achalasia, Female, Humans, Incidence, Male, Netherlands, Quality of Life, Retrospective Studies},\n\tpages = {110--115.e3},\n}\n\n\n\n","author_short":["Smits, M.","van Lennep, M.","Vrijlandt, R.","Benninga, M.","Oors, J.","Houwen, R.","Kokke, F.","van der Zee, D.","Escher, J.","van den Neucker, A.","de Meij, T.","Bodewes, F.","Schweizer, J.","Damen, G.","Busch, O.","van Wijk, M."],"key":"smits_pediatric_2016","id":"smits_pediatric_2016","bibbaseid":"smits-vanlennep-vrijlandt-benninga-oors-houwen-kokke-vanderzee-etal-pediatricachalasiainthenetherlandsincidenceclinicalcourseandqualityoflife-2016","role":"author","urls":{},"keyword":["Adolescent","Child","Cross-Sectional Studies","Esophageal Achalasia","Female","Humans","Incidence","Male","Netherlands","Quality of Life","Retrospective Studies"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/zotero-group/Leromela/5826776","dataSources":["tJu2LQsng3WaoKpcL","epXRk2zQpWZQCqqGz"],"keywords":["adolescent","child","cross-sectional studies","esophageal achalasia","female","humans","incidence","male","netherlands","quality of life","retrospective studies"],"search_terms":["pediatric","achalasia","netherlands","incidence","clinical","course","quality","life","smits","van lennep","vrijlandt","benninga","oors","houwen","kokke","van der zee","escher","van den neucker","de meij","bodewes","schweizer","damen","busch","van wijk"],"title":"Pediatric Achalasia in the Netherlands: Incidence, Clinical Course, and Quality of Life","year":2016}