Pathological evolution of hepatitis C virus-"Healthy carriers". Sobesky, R., Lebray, P., Nalpas, B., Vallet-Pichard, A., Fontaine, H., Lagneau, J. L., & Pol, S. World J Gastroenterol, 14(24):3861–5, June, 2008.
abstract   bibtex   
AIM: To determine factors associated with fibrosis progression in hepatitis C virus (HCV)-infected patients without significant initial pathological lesions. METHODS: Seventy six untreated HCV-infected patients with initially normal liver as defined by a Knodell score \textless or = 3, with 2 liver biopsies and detectable HCV-RNA were included. Markers of fibrosis progression were assessed. RESULTS: Median duration of infection and time between paired biopsies was 13 (95% CI: 1-28) and 4 (95% CI: 2-16) years respectively. Alanine-transaminase (ALT) activity was normal in 43.4% of cases. 50% demonstrated progression of the necro-inflammation and 34% of fibrosis after a median time evolution of 4 years (95% CI: 2-16). The median difference in the necro-inflammation and fibrosis score between biopsies was low, 1.5 and 0.0 respectively. Univariate analysis showed there was no difference between fibrosis activity or evolution according to genotype or viral load. A higher fibrosis progression (P = 0.03) was observed in patients with body mass index (BMI) \textgreater 25. Fibrosis progression correlated with the time interval between biopsies (P = 0.01). A significant progression of activity (1.7 vs 0.4, P \textless 0.05) or fibrosis (0.9 vs 0.0, P \textless 0.01) was observed in patients with elevated ALT. There was a significant correlation between activity progression and fibrosis progression (P = 0.003). Multivariate analysis demonstrated that fibrosis progression was associated with elevated ALT, BMI \textgreater 25 and the time interval between 2 biopsies. CONCLUSION: There is no fibrosis progression in 66% of patients without significant initial histopathological lesion. Fibrosis progression is associated with elevated ALT and BMI \textgreater 25.
@article{sobesky_pathological_2008,
	title = {Pathological evolution of hepatitis {C} virus-"{Healthy} carriers"},
	volume = {14},
	issn = {1007-9327 (PRINT); 1007-9327 (LINKING)},
	shorttitle = {Pathological evolution of hepatitis {C} virus-"{Healthy} carriers"},
	abstract = {AIM: To determine factors associated with fibrosis progression in hepatitis C virus (HCV)-infected patients without significant initial pathological lesions. METHODS: Seventy six untreated HCV-infected patients with initially normal liver as defined by a Knodell score {\textless} or = 3, with 2 liver biopsies and detectable HCV-RNA were included. Markers of fibrosis progression were assessed. RESULTS: Median duration of infection and time between paired biopsies was 13 (95\% CI: 1-28) and 4 (95\% CI: 2-16) years respectively. Alanine-transaminase (ALT) activity was normal in 43.4\% of cases. 50\% demonstrated progression of the necro-inflammation and 34\% of fibrosis after a median time evolution of 4 years (95\% CI: 2-16). The median difference in the necro-inflammation and fibrosis score between biopsies was low, 1.5 and 0.0 respectively. Univariate analysis showed there was no difference between fibrosis activity or evolution according to genotype or viral load. A higher fibrosis progression (P = 0.03) was observed in patients with body mass index (BMI) {\textgreater} 25. Fibrosis progression correlated with the time interval between biopsies (P = 0.01). A significant progression of activity (1.7 vs 0.4, P {\textless} 0.05) or fibrosis (0.9 vs 0.0, P {\textless} 0.01) was observed in patients with elevated ALT. There was a significant correlation between activity progression and fibrosis progression (P = 0.003). Multivariate analysis demonstrated that fibrosis progression was associated with elevated ALT, BMI {\textgreater} 25 and the time interval between 2 biopsies. CONCLUSION: There is no fibrosis progression in 66\% of patients without significant initial histopathological lesion. Fibrosis progression is associated with elevated ALT and BMI {\textgreater} 25.},
	number = {24},
	journal = {World J Gastroenterol},
	author = {Sobesky, R. and Lebray, P. and Nalpas, B. and Vallet-Pichard, A. and Fontaine, H. and Lagneau, J. L. and Pol, S.},
	month = jun,
	year = {2008},
	keywords = {Viral/blood Severity of Illness Index Viral Load},
	pages = {3861--5}
}

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