Role of NMDA receptor GluN2D subunit in the antidepressant effects of enantiomers of ketamine. Soichiro Ide, Yuiko Ikekuboa, Masayoshi Mishina, Kenji Hashimoto, K., I. Journal of Pharmacological Sciences, Elsevier, 11, 2017.
Role of NMDA receptor GluN2D subunit in the antidepressant effects of enantiomers of ketamine [link]Website  abstract   bibtex   
We investigated the rapid and sustained antidepressant effects of enantiomers of ketamine in N-methyl-d-aspartate (NMDA) receptor GluN2D subunit knockout (GluN2D-KO) mice. Intraperitoneal administration of ketamine or its enantiomers 10 min before the tail-suspension test exerted significant antidepressant effects on restraint stress-induced depression in both wildtype and GluN2D-KO mice. The antidepressant effects of (RS)-ketamine and (S)-ketamine were sustained 96 h after the injection in both wildtype and GluN2D-KO mice, but such sustained antidepressant effects of (R)-ketamine were only observed in wildtype mice. These data suggest that the GluN2D subunit is critical for the sustained antidepressant effects of (R)-ketamine.
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 title = {Role of NMDA receptor GluN2D subunit in the antidepressant effects of enantiomers of ketamine},
 type = {article},
 year = {2017},
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 month = {11},
 publisher = {Elsevier},
 day = {10},
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 abstract = {We investigated the rapid and sustained antidepressant effects of enantiomers of ketamine in N-methyl-d-aspartate (NMDA) receptor GluN2D subunit knockout (GluN2D-KO) mice. Intraperitoneal administration of ketamine or its enantiomers 10 min before the tail-suspension test exerted significant antidepressant effects on restraint stress-induced depression in both wildtype and GluN2D-KO mice. The antidepressant effects of (RS)-ketamine and (S)-ketamine were sustained 96 h after the injection in both wildtype and GluN2D-KO mice, but such sustained antidepressant effects of (R)-ketamine were only observed in wildtype mice. These data suggest that the GluN2D subunit is critical for the sustained antidepressant effects of (R)-ketamine.},
 bibtype = {article},
 author = {Soichiro Ide, Yuiko Ikekuboa, Masayoshi Mishina, Kenji Hashimoto, Kazutaka Ikeda},
 journal = {Journal of Pharmacological Sciences}
}

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