@article{soliman_prolongation_2012,
	title = {Prolongation of {QTc} and risk of stroke: {The} {REGARDS} ({REasons} for {Geographic} and {Racial} {Differences} in {Stroke}) study},
	volume = {59},
	issn = {1558-3597},
	shorttitle = {Prolongation of {QTc} and risk of stroke},
	doi = {10.1016/j.jacc.2012.01.025},
	abstract = {OBJECTIVES: The purpose of this study was to examine the association between prolongation of QT interval corrected for heart rate (QTc) with incident stroke.
BACKGROUND: Unlike cardiovascular morbidity and mortality, little is known about the relationship between QTc and risk of stroke.
METHODS: A total of 27,411 participants age 45 years and older without previous stroke from the REGARDS (REasons for Geographic and Racial Differences in Stroke) study were included in this analysis. QTc was calculated using Framingham formula (QTc(Fram)). Stroke cases were identified and adjudicated during up to 8.2 years of follow-up (median, 5.1 years).
RESULTS: The risk of incident stroke in study participants with prolonged QTc(Fram) was almost 3 times the risk in those with normal QTc(Fram) (hazard ratio [HR] [95\% confidence interval (CI)]: 2.88 [2.12 to 3.92], p {\textless} 0.0001). After adjustment for demographics (age, race, and sex), traditional stroke risk factors (antihypertensive medication use, systolic blood pressure, current smoking, diabetes, left ventricular hypertrophy, atrial fibrillation, and previous cardiovascular disease), warfarin use, aspirin use, QRS duration and use of QTc-prolonging drugs, the risk of stroke remained significantly high (HR [95\% CI]: 1.67 [1.16 to 2.41], p = 0.0061) and was consistent across several subgroups of REGARDS study participants. Similar results were obtained when the risk of stroke was estimated per 1-SD increase in QTc(Fram), (HR [95\% CI]: 1.12 [1.03 to 1.21], p = 0.0053 in multivariable-adjusted model) and when other QTc correction formulas including those of Hodge, Bazett, and Fridericia were used.
CONCLUSIONS: QTc prolongation is associated with a significantly increased risk of incident stroke independent of traditional stroke risk factors. Examining the risk of stroke associated with QTc-prolonging drugs may be warranted.},
	language = {eng},
	number = {16},
	journal = {Journal of the American College of Cardiology},
	author = {Soliman, Elsayed Z and Howard, George and Cushman, Mary and Kissela, Brett and Kleindorfer, Dawn and Le, Anh and Judd, Suzanne and McClure, Leslie A and Howard, Virginia J},
	month = apr,
	year = {2012},
	pmid = {22497826},
	keywords = {Aged, Continental Population Groups, Electrocardiography, Female, Follow-Up Studies, Heart Rate, Humans, Incidence, Long QT Syndrome, Male, Middle Aged, Prognosis, Retrospective Studies, Risk Assessment, Risk Factors, Stroke, Survival Rate, United States},
	pages = {1460--1467}
}

{"_id":"5D6RiF8GZwQuf5ADR","bibbaseid":"soliman-howard-cushman-kissela-kleindorfer-le-judd-mcclure-etal-prolongationofqtcandriskofstroketheregardsreasonsforgeographicandracialdifferencesinstrokestudy-2012","downloads":0,"creationDate":"2018-12-05T13:23:20.318Z","title":"Prolongation of QTc and risk of stroke: The REGARDS (REasons for Geographic and Racial Differences in Stroke) study","author_short":["Soliman, E. Z","Howard, G.","Cushman, M.","Kissela, B.","Kleindorfer, D.","Le, A.","Judd, S.","McClure, L. A","Howard, V. J"],"year":2012,"bibtype":"article","biburl":"https://bibbase.org/zotero/emmanuel.chazard","bibdata":{"bibtype":"article","type":"article","title":"Prolongation of QTc and risk of stroke: The REGARDS (REasons for Geographic and Racial Differences in Stroke) study","volume":"59","issn":"1558-3597","shorttitle":"Prolongation of QTc and risk of stroke","doi":"10.1016/j.jacc.2012.01.025","abstract":"OBJECTIVES: The purpose of this study was to examine the association between prolongation of QT interval corrected for heart rate (QTc) with incident stroke. BACKGROUND: Unlike cardiovascular morbidity and mortality, little is known about the relationship between QTc and risk of stroke. METHODS: A total of 27,411 participants age 45 years and older without previous stroke from the REGARDS (REasons for Geographic and Racial Differences in Stroke) study were included in this analysis. QTc was calculated using Framingham formula (QTc(Fram)). Stroke cases were identified and adjudicated during up to 8.2 years of follow-up (median, 5.1 years). RESULTS: The risk of incident stroke in study participants with prolonged QTc(Fram) was almost 3 times the risk in those with normal QTc(Fram) (hazard ratio [HR] [95% confidence interval (CI)]: 2.88 [2.12 to 3.92], p \\textless 0.0001). After adjustment for demographics (age, race, and sex), traditional stroke risk factors (antihypertensive medication use, systolic blood pressure, current smoking, diabetes, left ventricular hypertrophy, atrial fibrillation, and previous cardiovascular disease), warfarin use, aspirin use, QRS duration and use of QTc-prolonging drugs, the risk of stroke remained significantly high (HR [95% CI]: 1.67 [1.16 to 2.41], p = 0.0061) and was consistent across several subgroups of REGARDS study participants. Similar results were obtained when the risk of stroke was estimated per 1-SD increase in QTc(Fram), (HR [95% CI]: 1.12 [1.03 to 1.21], p = 0.0053 in multivariable-adjusted model) and when other QTc correction formulas including those of Hodge, Bazett, and Fridericia were used. CONCLUSIONS: QTc prolongation is associated with a significantly increased risk of incident stroke independent of traditional stroke risk factors. Examining the risk of stroke associated with QTc-prolonging drugs may be warranted.","language":"eng","number":"16","journal":"Journal of the American College of Cardiology","author":[{"propositions":[],"lastnames":["Soliman"],"firstnames":["Elsayed","Z"],"suffixes":[]},{"propositions":[],"lastnames":["Howard"],"firstnames":["George"],"suffixes":[]},{"propositions":[],"lastnames":["Cushman"],"firstnames":["Mary"],"suffixes":[]},{"propositions":[],"lastnames":["Kissela"],"firstnames":["Brett"],"suffixes":[]},{"propositions":[],"lastnames":["Kleindorfer"],"firstnames":["Dawn"],"suffixes":[]},{"propositions":[],"lastnames":["Le"],"firstnames":["Anh"],"suffixes":[]},{"propositions":[],"lastnames":["Judd"],"firstnames":["Suzanne"],"suffixes":[]},{"propositions":[],"lastnames":["McClure"],"firstnames":["Leslie","A"],"suffixes":[]},{"propositions":[],"lastnames":["Howard"],"firstnames":["Virginia","J"],"suffixes":[]}],"month":"April","year":"2012","pmid":"22497826","keywords":"Aged, Continental Population Groups, Electrocardiography, Female, Follow-Up Studies, Heart Rate, Humans, Incidence, Long QT Syndrome, Male, Middle Aged, Prognosis, Retrospective Studies, Risk Assessment, Risk Factors, Stroke, Survival Rate, United States","pages":"1460–1467","bibtex":"@article{soliman_prolongation_2012,\n\ttitle = {Prolongation of {QTc} and risk of stroke: {The} {REGARDS} ({REasons} for {Geographic} and {Racial} {Differences} in {Stroke}) study},\n\tvolume = {59},\n\tissn = {1558-3597},\n\tshorttitle = {Prolongation of {QTc} and risk of stroke},\n\tdoi = {10.1016/j.jacc.2012.01.025},\n\tabstract = {OBJECTIVES: The purpose of this study was to examine the association between prolongation of QT interval corrected for heart rate (QTc) with incident stroke.\nBACKGROUND: Unlike cardiovascular morbidity and mortality, little is known about the relationship between QTc and risk of stroke.\nMETHODS: A total of 27,411 participants age 45 years and older without previous stroke from the REGARDS (REasons for Geographic and Racial Differences in Stroke) study were included in this analysis. QTc was calculated using Framingham formula (QTc(Fram)). Stroke cases were identified and adjudicated during up to 8.2 years of follow-up (median, 5.1 years).\nRESULTS: The risk of incident stroke in study participants with prolonged QTc(Fram) was almost 3 times the risk in those with normal QTc(Fram) (hazard ratio [HR] [95\\% confidence interval (CI)]: 2.88 [2.12 to 3.92], p {\\textless} 0.0001). After adjustment for demographics (age, race, and sex), traditional stroke risk factors (antihypertensive medication use, systolic blood pressure, current smoking, diabetes, left ventricular hypertrophy, atrial fibrillation, and previous cardiovascular disease), warfarin use, aspirin use, QRS duration and use of QTc-prolonging drugs, the risk of stroke remained significantly high (HR [95\\% CI]: 1.67 [1.16 to 2.41], p = 0.0061) and was consistent across several subgroups of REGARDS study participants. Similar results were obtained when the risk of stroke was estimated per 1-SD increase in QTc(Fram), (HR [95\\% CI]: 1.12 [1.03 to 1.21], p = 0.0053 in multivariable-adjusted model) and when other QTc correction formulas including those of Hodge, Bazett, and Fridericia were used.\nCONCLUSIONS: QTc prolongation is associated with a significantly increased risk of incident stroke independent of traditional stroke risk factors. Examining the risk of stroke associated with QTc-prolonging drugs may be warranted.},\n\tlanguage = {eng},\n\tnumber = {16},\n\tjournal = {Journal of the American College of Cardiology},\n\tauthor = {Soliman, Elsayed Z and Howard, George and Cushman, Mary and Kissela, Brett and Kleindorfer, Dawn and Le, Anh and Judd, Suzanne and McClure, Leslie A and Howard, Virginia J},\n\tmonth = apr,\n\tyear = {2012},\n\tpmid = {22497826},\n\tkeywords = {Aged, Continental Population Groups, Electrocardiography, Female, Follow-Up Studies, Heart Rate, Humans, Incidence, Long QT Syndrome, Male, Middle Aged, Prognosis, Retrospective Studies, Risk Assessment, Risk Factors, Stroke, Survival Rate, United States},\n\tpages = {1460--1467}\n}\n\n","author_short":["Soliman, E. Z","Howard, G.","Cushman, M.","Kissela, B.","Kleindorfer, D.","Le, A.","Judd, S.","McClure, L. A","Howard, V. J"],"key":"soliman_prolongation_2012","id":"soliman_prolongation_2012","bibbaseid":"soliman-howard-cushman-kissela-kleindorfer-le-judd-mcclure-etal-prolongationofqtcandriskofstroketheregardsreasonsforgeographicandracialdifferencesinstrokestudy-2012","role":"author","urls":{},"keyword":["Aged","Continental Population Groups","Electrocardiography","Female","Follow-Up Studies","Heart Rate","Humans","Incidence","Long QT Syndrome","Male","Middle Aged","Prognosis","Retrospective Studies","Risk Assessment","Risk Factors","Stroke","Survival Rate","United States"],"downloads":0},"search_terms":["prolongation","qtc","risk","stroke","regards","reasons","geographic","racial","differences","stroke","study","soliman","howard","cushman","kissela","kleindorfer","le","judd","mcclure","howard"],"keywords":["aged","continental population groups","electrocardiography","female","follow-up studies","heart rate","humans","incidence","long qt syndrome","male","middle aged","prognosis","retrospective studies","risk assessment","risk factors","stroke","survival rate","united states"],"authorIDs":[],"dataSources":["XiRGowmyYWQpwjiC9"]}