@article{ sommer_frameless_2014,
  title = {Frameless stereotactic functional neuronavigation combined with intraoperative magnetic resonance imaging as a strategy in highly eloquent located tumors causing epilepsy.},
  volume = {92},
  url = {http://www.ncbi.nlm.nih.gov/pubmed/24356382},
  doi = {10.1159/000355216},
  abstract = {BACKGROUND: Intractable epilepsy due to tumors located in highly eloquent brain regions is often considered surgically inaccessible because of a high risk of postoperative neurological deterioration. Intraoperative MRI and functional navigation contribute to overcome this problem. OBJECTIVES: To retrospectively investigate the long-term results and impact of functional neuronavigation and 1.5-tesla intraoperative MRI on patients who underwent surgery of tumors associated with epilepsy located close to or within eloquent brain areas. METHODS: Nineteen patients (9 female, 10 male, mean age 41.4 ± 13.4 years, 11 low-grade and 8 high-grade glial tumors) were evaluated preoperatively using BOLD imaging, diffusion-tensor imaging tractography and magnetoencephalography. Functional data were implemented into neuronavigation in this multimodal approach. RESULTS: In 14 of 19 patients (74%), complete resection was achieved, and in 5 patients significant tumor volume reduction was accomplished. Eight of 14 (57%) complete resections were achieved only by performing an intraoperative image update. Neurological deterioration was found permanently in 2 patients. After a mean follow-up of 43.8 ± 23.8 months, 15 patients (79%) became seizure free (Engel class Ia). CONCLUSIONS: Despite the highly eloquent location of tumors causing intractable epilepsy, our multimodal approach led to complete resection in more than two-thirds of patients with an acceptable neurological morbidity and excellent long-term seizure control.},
  number = {1},
  journal = {Stereotactic and functional neurosurgery},
  author = {Sommer, Bjoern and Grummich, Peter and Hamer, Hajo and Bluemcke, Ingmar and Coras, Roland and Buchfelder, Michael and Roessler, Karl},
  month = {January},
  year = {2014},
  keywords = {Adult, Brain Neoplasms, Brain Neoplasms: complications, Brain Neoplasms: pathology, Brain Neoplasms: surgery, Cerebral Cortex, Cerebral Cortex: pathology, Electroencephalography, Epilepsy, Epilepsy: epidemiology, Epilepsy: etiology, Female, Follow-Up Studies, Humans, Incidence, Intraoperative Period, Magnetic Resonance Imaging, Magnetic Resonance Imaging: methods, Male, Middle Aged, Neuronavigation, Neuronavigation: methods, Neurosurgical Procedures, Neurosurgical Procedures: methods, Retrospective Studies, Treatment Outcome},
  pages = {59--67}
}

{"_id":"5cGs6y2FZ45oxb6EE","bibbaseid":"sommer-grummich-hamer-bluemcke-coras-buchfelder-roessler-framelessstereotacticfunctionalneuronavigationcombinedwithintraoperativemagneticresonanceimagingasastrategyinhighlyeloquentlocatedtumorscausingepilepsy-2014","downloads":0,"creationDate":"2015-08-12T12:24:01.241Z","title":"Frameless stereotactic functional neuronavigation combined with intraoperative magnetic resonance imaging as a strategy in highly eloquent located tumors causing epilepsy.","author_short":["Sommer, B.","Grummich, P.","Hamer, H.","Bluemcke, I.","Coras, R.","Buchfelder, M.","Roessler, K."],"year":2014,"bibtype":"article","biburl":"https://api.zotero.org/users/2578022/collections/NK7ID3DC/items?key=xfylOfgraRGkua7fIOIyUDtL&format=bibtex&limit=100","bibdata":{"abstract":"BACKGROUND: Intractable epilepsy due to tumors located in highly eloquent brain regions is often considered surgically inaccessible because of a high risk of postoperative neurological deterioration. Intraoperative MRI and functional navigation contribute to overcome this problem. OBJECTIVES: To retrospectively investigate the long-term results and impact of functional neuronavigation and 1.5-tesla intraoperative MRI on patients who underwent surgery of tumors associated with epilepsy located close to or within eloquent brain areas. METHODS: Nineteen patients (9 female, 10 male, mean age 41.4 ± 13.4 years, 11 low-grade and 8 high-grade glial tumors) were evaluated preoperatively using BOLD imaging, diffusion-tensor imaging tractography and magnetoencephalography. Functional data were implemented into neuronavigation in this multimodal approach. RESULTS: In 14 of 19 patients (74%), complete resection was achieved, and in 5 patients significant tumor volume reduction was accomplished. Eight of 14 (57%) complete resections were achieved only by performing an intraoperative image update. Neurological deterioration was found permanently in 2 patients. After a mean follow-up of 43.8 ± 23.8 months, 15 patients (79%) became seizure free (Engel class Ia). CONCLUSIONS: Despite the highly eloquent location of tumors causing intractable epilepsy, our multimodal approach led to complete resection in more than two-thirds of patients with an acceptable neurological morbidity and excellent long-term seizure control.","author":["Sommer, Bjoern","Grummich, Peter","Hamer, Hajo","Bluemcke, Ingmar","Coras, Roland","Buchfelder, Michael","Roessler, Karl"],"author_short":["Sommer, B.","Grummich, P.","Hamer, H.","Bluemcke, I.","Coras, R.","Buchfelder, M.","Roessler, K."],"bibtex":"@article{ sommer_frameless_2014,\n title = {Frameless stereotactic functional neuronavigation combined with intraoperative magnetic resonance imaging as a strategy in highly eloquent located tumors causing epilepsy.},\n volume = {92},\n url = {http://www.ncbi.nlm.nih.gov/pubmed/24356382},\n doi = {10.1159/000355216},\n abstract = {BACKGROUND: Intractable epilepsy due to tumors located in highly eloquent brain regions is often considered surgically inaccessible because of a high risk of postoperative neurological deterioration. Intraoperative MRI and functional navigation contribute to overcome this problem. OBJECTIVES: To retrospectively investigate the long-term results and impact of functional neuronavigation and 1.5-tesla intraoperative MRI on patients who underwent surgery of tumors associated with epilepsy located close to or within eloquent brain areas. METHODS: Nineteen patients (9 female, 10 male, mean age 41.4 ± 13.4 years, 11 low-grade and 8 high-grade glial tumors) were evaluated preoperatively using BOLD imaging, diffusion-tensor imaging tractography and magnetoencephalography. Functional data were implemented into neuronavigation in this multimodal approach. RESULTS: In 14 of 19 patients (74%), complete resection was achieved, and in 5 patients significant tumor volume reduction was accomplished. Eight of 14 (57%) complete resections were achieved only by performing an intraoperative image update. Neurological deterioration was found permanently in 2 patients. After a mean follow-up of 43.8 ± 23.8 months, 15 patients (79%) became seizure free (Engel class Ia). CONCLUSIONS: Despite the highly eloquent location of tumors causing intractable epilepsy, our multimodal approach led to complete resection in more than two-thirds of patients with an acceptable neurological morbidity and excellent long-term seizure control.},\n number = {1},\n journal = {Stereotactic and functional neurosurgery},\n author = {Sommer, Bjoern and Grummich, Peter and Hamer, Hajo and Bluemcke, Ingmar and Coras, Roland and Buchfelder, Michael and Roessler, Karl},\n month = {January},\n year = {2014},\n keywords = {Adult, Brain Neoplasms, Brain Neoplasms: complications, Brain Neoplasms: pathology, Brain Neoplasms: surgery, Cerebral Cortex, Cerebral Cortex: pathology, Electroencephalography, Epilepsy, Epilepsy: epidemiology, Epilepsy: etiology, Female, Follow-Up Studies, Humans, Incidence, Intraoperative Period, Magnetic Resonance Imaging, Magnetic Resonance Imaging: methods, Male, Middle Aged, Neuronavigation, Neuronavigation: methods, Neurosurgical Procedures, Neurosurgical Procedures: methods, Retrospective Studies, Treatment Outcome},\n pages = {59--67}\n}","bibtype":"article","doi":"10.1159/000355216","id":"sommer_frameless_2014","journal":"Stereotactic and functional neurosurgery","key":"sommer_frameless_2014","keywords":"Adult, Brain Neoplasms, Brain Neoplasms: complications, Brain Neoplasms: pathology, Brain Neoplasms: surgery, Cerebral Cortex, Cerebral Cortex: pathology, Electroencephalography, Epilepsy, Epilepsy: epidemiology, Epilepsy: etiology, Female, Follow-Up Studies, Humans, Incidence, Intraoperative Period, Magnetic Resonance Imaging, Magnetic Resonance Imaging: methods, Male, Middle Aged, Neuronavigation, Neuronavigation: methods, Neurosurgical Procedures, Neurosurgical Procedures: methods, Retrospective Studies, Treatment Outcome","month":"January","number":"1","pages":"59--67","title":"Frameless stereotactic functional neuronavigation combined with intraoperative magnetic resonance imaging as a strategy in highly eloquent located tumors causing epilepsy.","type":"article","url":"http://www.ncbi.nlm.nih.gov/pubmed/24356382","volume":"92","year":"2014","bibbaseid":"sommer-grummich-hamer-bluemcke-coras-buchfelder-roessler-framelessstereotacticfunctionalneuronavigationcombinedwithintraoperativemagneticresonanceimagingasastrategyinhighlyeloquentlocatedtumorscausingepilepsy-2014","role":"author","urls":{"Paper":"http://www.ncbi.nlm.nih.gov/pubmed/24356382"},"keyword":["Adult","Brain Neoplasms","Brain Neoplasms: complications","Brain Neoplasms: pathology","Brain Neoplasms: surgery","Cerebral Cortex","Cerebral Cortex: pathology","Electroencephalography","Epilepsy","Epilepsy: epidemiology","Epilepsy: etiology","Female","Follow-Up Studies","Humans","Incidence","Intraoperative Period","Magnetic Resonance Imaging","Magnetic Resonance Imaging: methods","Male","Middle Aged","Neuronavigation","Neuronavigation: methods","Neurosurgical Procedures","Neurosurgical Procedures: methods","Retrospective Studies","Treatment Outcome"],"downloads":0},"search_terms":["frameless","stereotactic","functional","neuronavigation","combined","intraoperative","magnetic","resonance","imaging","strategy","highly","eloquent","located","tumors","causing","epilepsy","sommer","grummich","hamer","bluemcke","coras","buchfelder","roessler"],"keywords":["adult","brain neoplasms","brain neoplasms: complications","brain neoplasms: pathology","brain neoplasms: surgery","cerebral cortex","cerebral cortex: pathology","electroencephalography","epilepsy","epilepsy: epidemiology","epilepsy: etiology","female","follow-up studies","humans","incidence","intraoperative period","magnetic resonance imaging","magnetic resonance imaging: methods","male","middle aged","neuronavigation","neuronavigation: methods","neurosurgical procedures","neurosurgical procedures: methods","retrospective studies","treatment outcome"],"authorIDs":[],"dataSources":["29267TEEN8oGNBtT4"]}