Triazole-based, optically-pure metallosupramolecules; highly potent and selective anticancer compounds. Song, H., Rogers, N. J., Brabec, V., Clarkson, G. J., Coverdale, J. P. C., Kostrhunova, H., Phillips, R. M., Postings, M., Shepherd, S. L., & Scott, P. CHEMICAL COMMUNICATIONS, 56(47):6392–6395, June, 2020. doi abstract bibtex Functionalised triazole aldehydes are used in the highly selective self-assembly of water-compatible, optically pure, low symmetry Fe(ii)- and Zn(ii)-based metallohelices. Sub-micromolar antiproliferative activity is observed against various cancerous cell lines, accompanied by excellent selectivityversusnon-cancerous cells and potential for synergistic combinatorial therapy with cisplatin.
@article{song_triazole-based_2020,
title = {Triazole-based, optically-pure metallosupramolecules; highly potent and selective anticancer compounds},
volume = {56},
issn = {1359-7345},
doi = {10.1039/d0cc02429e},
abstract = {Functionalised triazole aldehydes are used in the highly selective self-assembly of water-compatible, optically pure, low symmetry Fe(ii)- and Zn(ii)-based metallohelices. Sub-micromolar antiproliferative activity is observed against various cancerous cell lines, accompanied by excellent selectivityversusnon-cancerous cells and potential for synergistic combinatorial therapy with cisplatin.},
number = {47},
urldate = {2020-07-01},
journal = {CHEMICAL COMMUNICATIONS},
author = {Song, Hualong and Rogers, Nicola J. and Brabec, Viktor and Clarkson, Guy J. and Coverdale, James P. C. and Kostrhunova, Hana and Phillips, Roger M. and Postings, Miles and Shepherd, Samantha L. and Scott, Peter},
month = jun,
year = {2020},
pages = {6392--6395},
}
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