Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults. Sorrells, S. F, Paredes, M. F, Cebrian-Silla, A., Sandoval, K., Qi, D., Kelley, K. W, James, D., Mayer, S., Chang, J., Auguste, K. I, Chang, E. F, Gutierrez, A. J, Kriegstein, A. R, Mathern, G. W, Oldham, M. C, Huang, E. J, Garcia-Verdugo, J. M., Yang, Z., & Alvarez-Buylla, A. Nature, 555(7696):377–381, March, 2018.
abstract   bibtex   
New neurons continue to be generated in the subgranular zone of the dentate gyrus of the adult mammalian hippocampus. This process has been linked to learning and memory, stress and exercise, and is thought to be altered in neurological disease. In humans, some studies have suggested that hundreds of new neurons are added to the adult dentate gyrus every day, whereas other studies find many fewer putative new neurons. Despite these discrepancies, it is generally believed that the adult human hippocampus continues to generate new neurons. Here we show that a defined population of progenitor cells does not coalesce in the subgranular zone during human fetal or postnatal development. We also find that the number of proliferating progenitors and young neurons in the dentate gyrus declines sharply during the first year of life and only a few isolated young neurons are observed by 7 and 13 years of age. In adult patients with epilepsy and healthy adults (18-77 years; n = 17 post-mortem samples from controls; n = 12 surgical resection samples from patients with epilepsy), young neurons were not detected in the dentate gyrus. In the monkey (Macaca mulatta) hippocampus, proliferation of neurons in the subgranular zone was found in early postnatal life, but this diminished during juvenile development as neurogenesis decreased. We conclude that recruitment of young neurons to the primate hippocampus decreases rapidly during the first years of life, and that neurogenesis in the dentate gyrus does not continue, or is extremely rare, in adult humans. The early decline in hippocampal neurogenesis raises questions about how the function of the dentate gyrus differs between humans and other species in which adult hippocampal neurogenesis is preserved.
@ARTICLE{Sorrells2018-dx,
  title    = "Human hippocampal neurogenesis drops sharply in children to
              undetectable levels in adults",
  author   = "Sorrells, Shawn F and Paredes, Mercedes F and Cebrian-Silla,
              Arantxa and Sandoval, Kadellyn and Qi, Dashi and Kelley, Kevin W
              and James, David and Mayer, Simone and Chang, Julia and Auguste,
              Kurtis I and Chang, Edward F and Gutierrez, Antonio J and
              Kriegstein, Arnold R and Mathern, Gary W and Oldham, Michael C
              and Huang, Eric J and Garcia-Verdugo, Jose Manuel and Yang,
              Zhengang and Alvarez-Buylla, Arturo",
  abstract = "New neurons continue to be generated in the subgranular zone of
              the dentate gyrus of the adult mammalian hippocampus. This
              process has been linked to learning and memory, stress and
              exercise, and is thought to be altered in neurological disease.
              In humans, some studies have suggested that hundreds of new
              neurons are added to the adult dentate gyrus every day, whereas
              other studies find many fewer putative new neurons. Despite these
              discrepancies, it is generally believed that the adult human
              hippocampus continues to generate new neurons. Here we show that
              a defined population of progenitor cells does not coalesce in the
              subgranular zone during human fetal or postnatal development. We
              also find that the number of proliferating progenitors and young
              neurons in the dentate gyrus declines sharply during the first
              year of life and only a few isolated young neurons are observed
              by 7 and 13 years of age. In adult patients with epilepsy and
              healthy adults (18-77 years; n = 17 post-mortem samples from
              controls; n = 12 surgical resection samples from patients with
              epilepsy), young neurons were not detected in the dentate gyrus.
              In the monkey (Macaca mulatta) hippocampus, proliferation of
              neurons in the subgranular zone was found in early postnatal
              life, but this diminished during juvenile development as
              neurogenesis decreased. We conclude that recruitment of young
              neurons to the primate hippocampus decreases rapidly during the
              first years of life, and that neurogenesis in the dentate gyrus
              does not continue, or is extremely rare, in adult humans. The
              early decline in hippocampal neurogenesis raises questions about
              how the function of the dentate gyrus differs between humans and
              other species in which adult hippocampal neurogenesis is
              preserved.",
  journal  = "Nature",
  volume   =  555,
  number   =  7696,
  pages    = "377--381",
  month    =  mar,
  year     =  2018,
  language = "en"
}
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