Interneurons from embryonic development to cell-based therapy. Southwell, D. G, Nicholas, C. R, Basbaum, A. I, Stryker, M. P, Kriegstein, A. R, Rubenstein, J. L, & Alvarez-Buylla, A. Science, 344(6180):1240622, April, 2014.
abstract   bibtex   
Many neurologic and psychiatric disorders are marked by imbalances between neural excitation and inhibition. In the cerebral cortex, inhibition is mediated largely by GABAergic ($γ$-aminobutyric acid-secreting) interneurons, a cell type that originates in the embryonic ventral telencephalon and populates the cortex through long-distance tangential migration. Remarkably, when transplanted from embryos or in vitro culture preparations, immature interneurons disperse and integrate into host brain circuits, both in the cerebral cortex and in other regions of the central nervous system. These features make interneuron transplantation a powerful tool for the study of neurodevelopmental processes such as cell specification, cell death, and cortical plasticity. Moreover, interneuron transplantation provides a novel strategy for modifying neural circuits in rodent models of epilepsy, Parkinson's disease, mood disorders, and chronic pain.
@ARTICLE{Southwell2014-fq,
  title    = "Interneurons from embryonic development to cell-based therapy",
  author   = "Southwell, Derek G and Nicholas, Cory R and Basbaum, Allan I and
              Stryker, Michael P and Kriegstein, Arnold R and Rubenstein, John
              L and Alvarez-Buylla, Arturo",
  abstract = "Many neurologic and psychiatric disorders are marked by
              imbalances between neural excitation and inhibition. In the
              cerebral cortex, inhibition is mediated largely by GABAergic
              ($\gamma$-aminobutyric acid-secreting) interneurons, a cell type
              that originates in the embryonic ventral telencephalon and
              populates the cortex through long-distance tangential migration.
              Remarkably, when transplanted from embryos or in vitro culture
              preparations, immature interneurons disperse and integrate into
              host brain circuits, both in the cerebral cortex and in other
              regions of the central nervous system. These features make
              interneuron transplantation a powerful tool for the study of
              neurodevelopmental processes such as cell specification, cell
              death, and cortical plasticity. Moreover, interneuron
              transplantation provides a novel strategy for modifying neural
              circuits in rodent models of epilepsy, Parkinson's disease, mood
              disorders, and chronic pain.",
  journal  = "Science",
  volume   =  344,
  number   =  6180,
  pages    = "1240622",
  month    =  apr,
  year     =  2014,
  language = "en"
}

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