Meta-analysis shows colon capsule endoscopy is effective in detecting colorectal polyps. Spada, C., Hassan, C., Marmo, R., Petruzziello, L., Riccioni, M. E., Zullo, A., Cesaro, P., Pilz, J., & Costamagna, G. Clinical Gastroenterology and Hepatology: The Official Clinical Practice Journal of the American Gastroenterological Association, 8(6):516–522, June, 2010. doi abstract bibtex BACKGROUND & AIMS: Colon capsule endoscopy (CCE) is a noninvasive and painless technique used to explore the colon without sedation or air insufflation. We performed a systematic review and meta-analysis to assess the accuracy of CCE in detecting colorectal polyps. METHODS: The MEDLINE, EMBASE, and SCOPUS databases were searched, from 2006 to 2009, for the terms "colon capsule" and "Pillcam colon"; searches included abstracts. Studies were included that focused on detecting colorectal polyps with CCE and that were verified using within-subject reference colonoscopy. The risk of bias within each study was ascertained according to Quality Assessment of Diagnostic Accuracy in Systematic Reviews recommendations. The per-patient sensitivity and specificity were calculated for polyps of any size and for significant findings (polyps, \textgreater or =6 mm in size or \textgreater3 in number). Forest plots were produced based on random-effect models. The risk of bias across studies was assessed using the interstudy heterogeneity statistic, meta-regression, and the Egger test. RESULTS: Eight studies provided data on 837 patients; the prevalences of polyps and significant findings were 57% and 27.4%, respectively. CCE sensitivity for polyps of any size and significant findings were 71% and 68%, respectively. CCE specificity for polyps of any size and significant findings were 75% and 82%, respectively. High levels of heterogeneity (interstudy heterogeneity, \textgreater75%) were not detected. Moderate heterogeneity partially was explained by the different design of individual studies. CCE identified 16 of the 21 cancerous lesions detected by colonoscopy (pooled sensitivity, 76%). CONCLUSIONS: CCE sensitivity for polyps and significant findings compares favorably with other noninvasive colorectal cancer screening strategies. CCE specificity is likely to be underestimated because reference colonoscopy examination results are blinded.
@article{spada_meta-analysis_2010,
title = {Meta-analysis shows colon capsule endoscopy is effective in detecting colorectal polyps},
volume = {8},
issn = {1542-7714},
doi = {10.1016/j.cgh.2010.02.018},
abstract = {BACKGROUND \& AIMS: Colon capsule endoscopy (CCE) is a noninvasive and painless technique used to explore the colon without sedation or air insufflation. We performed a systematic review and meta-analysis to assess the accuracy of CCE in detecting colorectal polyps.
METHODS: The MEDLINE, EMBASE, and SCOPUS databases were searched, from 2006 to 2009, for the terms "colon capsule" and "Pillcam colon"; searches included abstracts. Studies were included that focused on detecting colorectal polyps with CCE and that were verified using within-subject reference colonoscopy. The risk of bias within each study was ascertained according to Quality Assessment of Diagnostic Accuracy in Systematic Reviews recommendations. The per-patient sensitivity and specificity were calculated for polyps of any size and for significant findings (polyps, {\textgreater} or =6 mm in size or {\textgreater}3 in number). Forest plots were produced based on random-effect models. The risk of bias across studies was assessed using the interstudy heterogeneity statistic, meta-regression, and the Egger test.
RESULTS: Eight studies provided data on 837 patients; the prevalences of polyps and significant findings were 57\% and 27.4\%, respectively. CCE sensitivity for polyps of any size and significant findings were 71\% and 68\%, respectively. CCE specificity for polyps of any size and significant findings were 75\% and 82\%, respectively. High levels of heterogeneity (interstudy heterogeneity, {\textgreater}75\%) were not detected. Moderate heterogeneity partially was explained by the different design of individual studies. CCE identified 16 of the 21 cancerous lesions detected by colonoscopy (pooled sensitivity, 76\%).
CONCLUSIONS: CCE sensitivity for polyps and significant findings compares favorably with other noninvasive colorectal cancer screening strategies. CCE specificity is likely to be underestimated because reference colonoscopy examination results are blinded.},
language = {eng},
number = {6},
journal = {Clinical Gastroenterology and Hepatology: The Official Clinical Practice Journal of the American Gastroenterological Association},
author = {Spada, Cristiano and Hassan, Cesare and Marmo, Riccardo and Petruzziello, Lucio and Riccioni, Maria Elena and Zullo, Angelo and Cesaro, Paola and Pilz, Julia and Costamagna, Guido},
month = jun,
year = {2010},
pmid = {20215066},
keywords = {Capsule Endoscopy, Colorectal Neoplasms, Female, Humans, Male, Middle Aged, Polyps, Sensitivity and Specificity},
pages = {516--522},
}
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{"_id":"arcdSAspuJRQmBF4T","bibbaseid":"spada-hassan-marmo-petruzziello-riccioni-zullo-cesaro-pilz-etal-metaanalysisshowscoloncapsuleendoscopyiseffectiveindetectingcolorectalpolyps-2010","author_short":["Spada, C.","Hassan, C.","Marmo, R.","Petruzziello, L.","Riccioni, M. E.","Zullo, A.","Cesaro, P.","Pilz, J.","Costamagna, G."],"bibdata":{"bibtype":"article","type":"article","title":"Meta-analysis shows colon capsule endoscopy is effective in detecting colorectal polyps","volume":"8","issn":"1542-7714","doi":"10.1016/j.cgh.2010.02.018","abstract":"BACKGROUND & AIMS: Colon capsule endoscopy (CCE) is a noninvasive and painless technique used to explore the colon without sedation or air insufflation. We performed a systematic review and meta-analysis to assess the accuracy of CCE in detecting colorectal polyps. METHODS: The MEDLINE, EMBASE, and SCOPUS databases were searched, from 2006 to 2009, for the terms \"colon capsule\" and \"Pillcam colon\"; searches included abstracts. Studies were included that focused on detecting colorectal polyps with CCE and that were verified using within-subject reference colonoscopy. The risk of bias within each study was ascertained according to Quality Assessment of Diagnostic Accuracy in Systematic Reviews recommendations. The per-patient sensitivity and specificity were calculated for polyps of any size and for significant findings (polyps, \\textgreater or =6 mm in size or \\textgreater3 in number). Forest plots were produced based on random-effect models. The risk of bias across studies was assessed using the interstudy heterogeneity statistic, meta-regression, and the Egger test. RESULTS: Eight studies provided data on 837 patients; the prevalences of polyps and significant findings were 57% and 27.4%, respectively. CCE sensitivity for polyps of any size and significant findings were 71% and 68%, respectively. CCE specificity for polyps of any size and significant findings were 75% and 82%, respectively. High levels of heterogeneity (interstudy heterogeneity, \\textgreater75%) were not detected. Moderate heterogeneity partially was explained by the different design of individual studies. CCE identified 16 of the 21 cancerous lesions detected by colonoscopy (pooled sensitivity, 76%). CONCLUSIONS: CCE sensitivity for polyps and significant findings compares favorably with other noninvasive colorectal cancer screening strategies. CCE specificity is likely to be underestimated because reference colonoscopy examination results are blinded.","language":"eng","number":"6","journal":"Clinical Gastroenterology and Hepatology: The Official Clinical Practice Journal of the American Gastroenterological Association","author":[{"propositions":[],"lastnames":["Spada"],"firstnames":["Cristiano"],"suffixes":[]},{"propositions":[],"lastnames":["Hassan"],"firstnames":["Cesare"],"suffixes":[]},{"propositions":[],"lastnames":["Marmo"],"firstnames":["Riccardo"],"suffixes":[]},{"propositions":[],"lastnames":["Petruzziello"],"firstnames":["Lucio"],"suffixes":[]},{"propositions":[],"lastnames":["Riccioni"],"firstnames":["Maria","Elena"],"suffixes":[]},{"propositions":[],"lastnames":["Zullo"],"firstnames":["Angelo"],"suffixes":[]},{"propositions":[],"lastnames":["Cesaro"],"firstnames":["Paola"],"suffixes":[]},{"propositions":[],"lastnames":["Pilz"],"firstnames":["Julia"],"suffixes":[]},{"propositions":[],"lastnames":["Costamagna"],"firstnames":["Guido"],"suffixes":[]}],"month":"June","year":"2010","pmid":"20215066","keywords":"Capsule Endoscopy, Colorectal Neoplasms, Female, Humans, Male, Middle Aged, Polyps, Sensitivity and Specificity","pages":"516–522","bibtex":"@article{spada_meta-analysis_2010,\n\ttitle = {Meta-analysis shows colon capsule endoscopy is effective in detecting colorectal polyps},\n\tvolume = {8},\n\tissn = {1542-7714},\n\tdoi = {10.1016/j.cgh.2010.02.018},\n\tabstract = {BACKGROUND \\& AIMS: Colon capsule endoscopy (CCE) is a noninvasive and painless technique used to explore the colon without sedation or air insufflation. We performed a systematic review and meta-analysis to assess the accuracy of CCE in detecting colorectal polyps.\nMETHODS: The MEDLINE, EMBASE, and SCOPUS databases were searched, from 2006 to 2009, for the terms \"colon capsule\" and \"Pillcam colon\"; searches included abstracts. Studies were included that focused on detecting colorectal polyps with CCE and that were verified using within-subject reference colonoscopy. The risk of bias within each study was ascertained according to Quality Assessment of Diagnostic Accuracy in Systematic Reviews recommendations. The per-patient sensitivity and specificity were calculated for polyps of any size and for significant findings (polyps, {\\textgreater} or =6 mm in size or {\\textgreater}3 in number). Forest plots were produced based on random-effect models. The risk of bias across studies was assessed using the interstudy heterogeneity statistic, meta-regression, and the Egger test.\nRESULTS: Eight studies provided data on 837 patients; the prevalences of polyps and significant findings were 57\\% and 27.4\\%, respectively. CCE sensitivity for polyps of any size and significant findings were 71\\% and 68\\%, respectively. CCE specificity for polyps of any size and significant findings were 75\\% and 82\\%, respectively. High levels of heterogeneity (interstudy heterogeneity, {\\textgreater}75\\%) were not detected. Moderate heterogeneity partially was explained by the different design of individual studies. CCE identified 16 of the 21 cancerous lesions detected by colonoscopy (pooled sensitivity, 76\\%).\nCONCLUSIONS: CCE sensitivity for polyps and significant findings compares favorably with other noninvasive colorectal cancer screening strategies. CCE specificity is likely to be underestimated because reference colonoscopy examination results are blinded.},\n\tlanguage = {eng},\n\tnumber = {6},\n\tjournal = {Clinical Gastroenterology and Hepatology: The Official Clinical Practice Journal of the American Gastroenterological Association},\n\tauthor = {Spada, Cristiano and Hassan, Cesare and Marmo, Riccardo and Petruzziello, Lucio and Riccioni, Maria Elena and Zullo, Angelo and Cesaro, Paola and Pilz, Julia and Costamagna, Guido},\n\tmonth = jun,\n\tyear = {2010},\n\tpmid = {20215066},\n\tkeywords = {Capsule Endoscopy, Colorectal Neoplasms, Female, Humans, Male, Middle Aged, Polyps, Sensitivity and Specificity},\n\tpages = {516--522},\n}\n\n\n\n","author_short":["Spada, C.","Hassan, C.","Marmo, R.","Petruzziello, L.","Riccioni, M. E.","Zullo, A.","Cesaro, P.","Pilz, J.","Costamagna, G."],"key":"spada_meta-analysis_2010","id":"spada_meta-analysis_2010","bibbaseid":"spada-hassan-marmo-petruzziello-riccioni-zullo-cesaro-pilz-etal-metaanalysisshowscoloncapsuleendoscopyiseffectiveindetectingcolorectalpolyps-2010","role":"author","urls":{},"keyword":["Capsule Endoscopy","Colorectal Neoplasms","Female","Humans","Male","Middle Aged","Polyps","Sensitivity and Specificity"],"metadata":{"authorlinks":{}},"html":""},"bibtype":"article","biburl":"https://bibbase.org/zotero/nikitaj.greenidge","dataSources":["uXDRqZDxuAtbLLS2T"],"keywords":["capsule endoscopy","colorectal neoplasms","female","humans","male","middle aged","polyps","sensitivity and specificity"],"search_terms":["meta","analysis","shows","colon","capsule","endoscopy","effective","detecting","colorectal","polyps","spada","hassan","marmo","petruzziello","riccioni","zullo","cesaro","pilz","costamagna"],"title":"Meta-analysis shows colon capsule endoscopy is effective in detecting colorectal polyps","year":2010}