Biological differences between melancholic and nonmelancholic depression subtyped by the CORE measure. Spanemberg, L., Caldieraro, M. A., Vares, E. A., Wollenhaupt-Aguiar, B., Kauer-Sant'Anna, M., Kawamoto, S. Y., Galvão, E., Parker, G., & Fleck, M. P Neuropsychiatric disease and treatment, 10:1523--1531, 2014. ![Biological differences between melancholic and nonmelancholic depression subtyped by the CORE measure [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex BACKGROUND: The purpose of this study was to compare melancholic patients rated by the CORE measure of observable psychomotor disturbance with nonmelancholic and control subjects across a set of biomarkers. METHODS: Depressed patients were classified as melancholic or nonmelancholic by using the CORE measure. Both groups of patients, as well as control subjects, were compared for a set of clinical and laboratory measures. Serum levels of brain-derived neurotrophic factor, of two markers of oxidative stress (protein carbonyl content [PCC] and thiobarbituric acid reactive substances [TBARS]), and of several immunity markers (interleukin [IL]-2, IL-4, IL-6, IL-10, IL-17, tumor necrosis factor-alpha, and interferon-gamma) were analyzed. RESULTS: Thirty-three depressed patients and 54 healthy controls were studied. Depressive patients showed higher IL-4, IL-6, and PCC values than healthy controls. Thirteen (39%) of the depressed patients were assigned as melancholic by the CORE measure. They generated lower interferon-gamma (compared with nonmelancholic depressed patients) and TBARS (compared with both the nonmelancholic subset and controls) and returned higher IL-6 levels than controls. Both depressive groups generated higher PCC scores than controls, with no difference between melancholic and nonmelancholic subsets. CONCLUSION: A sign-based measure to rate melancholia was able to replicate and extend biological findings discriminating melancholic depression. Signs of psychomotor disturbance may be a useful diagnostic measure of melancholia.
@article{spanemberg_biological_2014,
title = {Biological differences between melancholic and nonmelancholic depression subtyped by the {CORE} measure},
volume = {10},
issn = {1176-6328},
url = {http://dx.doi.org/10.2147/NDT.S66504},
doi = {10.2147/NDT.S66504},
abstract = {BACKGROUND: The purpose of this study was to compare melancholic patients rated by the CORE measure of observable psychomotor disturbance with nonmelancholic and control subjects across a set of biomarkers. METHODS: Depressed patients were classified as melancholic or nonmelancholic by using the CORE measure. Both groups of patients, as well as control subjects, were compared for a set of clinical and laboratory measures. Serum levels of brain-derived neurotrophic factor, of two markers of oxidative stress (protein carbonyl content [PCC] and thiobarbituric acid reactive substances [TBARS]), and of several immunity markers (interleukin [IL]-2, IL-4, IL-6, IL-10, IL-17, tumor necrosis factor-alpha, and interferon-gamma) were analyzed. RESULTS: Thirty-three depressed patients and 54 healthy controls were studied. Depressive patients showed higher IL-4, IL-6, and PCC values than healthy controls. Thirteen (39\%) of the depressed patients were assigned as melancholic by the CORE measure. They generated lower interferon-gamma (compared with nonmelancholic depressed patients) and TBARS (compared with both the nonmelancholic subset and controls) and returned higher IL-6 levels than controls. Both depressive groups generated higher PCC scores than controls, with no difference between melancholic and nonmelancholic subsets. CONCLUSION: A sign-based measure to rate melancholia was able to replicate and extend biological findings discriminating melancholic depression. Signs of psychomotor disturbance may be a useful diagnostic measure of melancholia.},
language = {en},
journal = {Neuropsychiatric disease and treatment},
author = {Spanemberg, Lucas and Caldieraro, Marco Antonio and Vares, Edgar Arrua and Wollenhaupt-Aguiar, Bianca and Kauer-Sant'Anna, Márcia and Kawamoto, Sheila Yuri and Galvão, Emily and Parker, Gordon and Fleck, Marcelo P},
year = {2014},
pmid = {25187716},
keywords = {Mental Health/Care: Psychiatry, brain-derived neurotrophic factor, inflammatory cytokines, melancholic depression, oxidative stress},
pages = {1523--1531}
}
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P"],"year":2014,"bibtype":"article","biburl":"http://bibbase.org/zotero/davidlloyd3","bibdata":{"bibtype":"article","type":"article","title":"Biological differences between melancholic and nonmelancholic depression subtyped by the CORE measure","volume":"10","issn":"1176-6328","url":"http://dx.doi.org/10.2147/NDT.S66504","doi":"10.2147/NDT.S66504","abstract":"BACKGROUND: The purpose of this study was to compare melancholic patients rated by the CORE measure of observable psychomotor disturbance with nonmelancholic and control subjects across a set of biomarkers. METHODS: Depressed patients were classified as melancholic or nonmelancholic by using the CORE measure. Both groups of patients, as well as control subjects, were compared for a set of clinical and laboratory measures. Serum levels of brain-derived neurotrophic factor, of two markers of oxidative stress (protein carbonyl content [PCC] and thiobarbituric acid reactive substances [TBARS]), and of several immunity markers (interleukin [IL]-2, IL-4, IL-6, IL-10, IL-17, tumor necrosis factor-alpha, and interferon-gamma) were analyzed. RESULTS: Thirty-three depressed patients and 54 healthy controls were studied. Depressive patients showed higher IL-4, IL-6, and PCC values than healthy controls. Thirteen (39%) of the depressed patients were assigned as melancholic by the CORE measure. They generated lower interferon-gamma (compared with nonmelancholic depressed patients) and TBARS (compared with both the nonmelancholic subset and controls) and returned higher IL-6 levels than controls. Both depressive groups generated higher PCC scores than controls, with no difference between melancholic and nonmelancholic subsets. CONCLUSION: A sign-based measure to rate melancholia was able to replicate and extend biological findings discriminating melancholic depression. Signs of psychomotor disturbance may be a useful diagnostic measure of melancholia.","language":"en","journal":"Neuropsychiatric disease and treatment","author":[{"propositions":[],"lastnames":["Spanemberg"],"firstnames":["Lucas"],"suffixes":[]},{"propositions":[],"lastnames":["Caldieraro"],"firstnames":["Marco","Antonio"],"suffixes":[]},{"propositions":[],"lastnames":["Vares"],"firstnames":["Edgar","Arrua"],"suffixes":[]},{"propositions":[],"lastnames":["Wollenhaupt-Aguiar"],"firstnames":["Bianca"],"suffixes":[]},{"propositions":[],"lastnames":["Kauer-Sant'Anna"],"firstnames":["Márcia"],"suffixes":[]},{"propositions":[],"lastnames":["Kawamoto"],"firstnames":["Sheila","Yuri"],"suffixes":[]},{"propositions":[],"lastnames":["Galvão"],"firstnames":["Emily"],"suffixes":[]},{"propositions":[],"lastnames":["Parker"],"firstnames":["Gordon"],"suffixes":[]},{"propositions":[],"lastnames":["Fleck"],"firstnames":["Marcelo","P"],"suffixes":[]}],"year":"2014","pmid":"25187716","keywords":"Mental Health/Care: Psychiatry, brain-derived neurotrophic factor, inflammatory cytokines, melancholic depression, oxidative stress","pages":"1523--1531","bibtex":"@article{spanemberg_biological_2014,\n\ttitle = {Biological differences between melancholic and nonmelancholic depression subtyped by the {CORE} measure},\n\tvolume = {10},\n\tissn = {1176-6328},\n\turl = {http://dx.doi.org/10.2147/NDT.S66504},\n\tdoi = {10.2147/NDT.S66504},\n\tabstract = {BACKGROUND: The purpose of this study was to compare melancholic patients rated by the CORE measure of observable psychomotor disturbance with nonmelancholic and control subjects across a set of biomarkers. METHODS: Depressed patients were classified as melancholic or nonmelancholic by using the CORE measure. Both groups of patients, as well as control subjects, were compared for a set of clinical and laboratory measures. Serum levels of brain-derived neurotrophic factor, of two markers of oxidative stress (protein carbonyl content [PCC] and thiobarbituric acid reactive substances [TBARS]), and of several immunity markers (interleukin [IL]-2, IL-4, IL-6, IL-10, IL-17, tumor necrosis factor-alpha, and interferon-gamma) were analyzed. RESULTS: Thirty-three depressed patients and 54 healthy controls were studied. Depressive patients showed higher IL-4, IL-6, and PCC values than healthy controls. Thirteen (39\\%) of the depressed patients were assigned as melancholic by the CORE measure. They generated lower interferon-gamma (compared with nonmelancholic depressed patients) and TBARS (compared with both the nonmelancholic subset and controls) and returned higher IL-6 levels than controls. Both depressive groups generated higher PCC scores than controls, with no difference between melancholic and nonmelancholic subsets. CONCLUSION: A sign-based measure to rate melancholia was able to replicate and extend biological findings discriminating melancholic depression. Signs of psychomotor disturbance may be a useful diagnostic measure of melancholia.},\n\tlanguage = {en},\n\tjournal = {Neuropsychiatric disease and treatment},\n\tauthor = {Spanemberg, Lucas and Caldieraro, Marco Antonio and Vares, Edgar Arrua and Wollenhaupt-Aguiar, Bianca and Kauer-Sant'Anna, Márcia and Kawamoto, Sheila Yuri and Galvão, Emily and Parker, Gordon and Fleck, Marcelo P},\n\tyear = {2014},\n\tpmid = {25187716},\n\tkeywords = {Mental Health/Care: Psychiatry, brain-derived neurotrophic factor, inflammatory cytokines, melancholic depression, oxidative stress},\n\tpages = {1523--1531}\n}\n\n","author_short":["Spanemberg, L.","Caldieraro, M. A.","Vares, E. 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