@article{squires_serotonin_2010,
	title = {Serotonin and its metabolism in basal deuterostomes: insights from \textit{{Strongylocentrotus} purpuratus} and \textit{{Xenoturbella} bocki}},
	volume = {213},
	issn = {1477-9145, 0022-0949},
	shorttitle = {Serotonin and its metabolism in basal deuterostomes},
	url = {https://journals.biologists.com/jeb/article/213/15/2647/9729/Serotonin-and-its-metabolism-in-basal},
	doi = {10.1242/jeb.042374},
	abstract = {SUMMARY
            Serotonin (5-HT), an important molecule in metazoans, is involved in a range of biological processes including neurotransmission and neuromodulation. Both its creation and release are tightly regulated, as is its removal. Multiple neurochemical pathways are responsible for the catabolism of 5-HT and are phyla specific; therefore, by elucidating these catabolic pathways we glean greater understanding of the relationships and origins of various transmitter systems. Here, 5-HT catabolic pathways were studied in Strongylocentrotus purpuratus and Xenoturbella bocki, two organisms occupying distinct positions in deuterostomes. The 5-HT-related compounds detected in these organisms were compared with those reported in other phyla. In S. purpuratus, 5-HT-related metabolites include N-acetyl serotonin, γ-glutamyl-serotonin and 5-hydroxyindole acetic acid; the quantity and type were found to vary based on the specific tissues analyzed. In addition to these compounds, varying levels of tryptamine were also seen. Upon addition of a 5-HT precursor and a monoamine oxidase inhibitor, 5-HT itself was detected. In similar experiments using X. bocki tissues, the 5-HT-related compounds found included 5-HT sulfate, γ-glutamyl-serotonin and 5-hydroxyindole acetic acid, as well as 5-HT and tryptamine. The sea urchin metabolizes 5-HT in a manner similar to both gastropod mollusks, as evidenced by the detection of γ-glutamyl-serotonin, and vertebrates, as indicated by the presence of 5-hydroxyindole acetic acid and N-acetyl serotonin. In contrast, 5-HT metabolism in X. bocki appears more similar to common protostome 5-HT catabolic pathways.},
	language = {en},
	number = {15},
	urldate = {2021-07-27},
	journal = {Journal of Experimental Biology},
	author = {Squires, Leah N. and Rubakhin, Stanislav S. and Wadhams, Andinet Amare and Talbot, Kristen N. and Nakano, Hiroaki and Moroz, Leonid L. and Sweedler, Jonathan V.},
	month = aug,
	year = {2010},
	pages = {2647--2654},
}

{"_id":"X7aiS9MaQcJ64tj7C","bibbaseid":"squires-rubakhin-wadhams-talbot-nakano-moroz-sweedler-serotoninanditsmetabolisminbasaldeuterostomesinsightsfromistrongylocentrotuspurpuratusiandixenoturbellabockii-2010","author_short":["Squires, L. N.","Rubakhin, S. S.","Wadhams, A. A.","Talbot, K. N.","Nakano, H.","Moroz, L. L.","Sweedler, J. V."],"bibdata":{"bibtype":"article","type":"article","title":"Serotonin and its metabolism in basal deuterostomes: insights from <i>Strongylocentrotus purpuratus</i> and <i>Xenoturbella bocki</i>","volume":"213","issn":"1477-9145, 0022-0949","shorttitle":"Serotonin and its metabolism in basal deuterostomes","url":"https://journals.biologists.com/jeb/article/213/15/2647/9729/Serotonin-and-its-metabolism-in-basal","doi":"10.1242/jeb.042374","abstract":"SUMMARY Serotonin (5-HT), an important molecule in metazoans, is involved in a range of biological processes including neurotransmission and neuromodulation. Both its creation and release are tightly regulated, as is its removal. Multiple neurochemical pathways are responsible for the catabolism of 5-HT and are phyla specific; therefore, by elucidating these catabolic pathways we glean greater understanding of the relationships and origins of various transmitter systems. Here, 5-HT catabolic pathways were studied in Strongylocentrotus purpuratus and Xenoturbella bocki, two organisms occupying distinct positions in deuterostomes. The 5-HT-related compounds detected in these organisms were compared with those reported in other phyla. In S. purpuratus, 5-HT-related metabolites include N-acetyl serotonin, γ-glutamyl-serotonin and 5-hydroxyindole acetic acid; the quantity and type were found to vary based on the specific tissues analyzed. In addition to these compounds, varying levels of tryptamine were also seen. Upon addition of a 5-HT precursor and a monoamine oxidase inhibitor, 5-HT itself was detected. In similar experiments using X. bocki tissues, the 5-HT-related compounds found included 5-HT sulfate, γ-glutamyl-serotonin and 5-hydroxyindole acetic acid, as well as 5-HT and tryptamine. The sea urchin metabolizes 5-HT in a manner similar to both gastropod mollusks, as evidenced by the detection of γ-glutamyl-serotonin, and vertebrates, as indicated by the presence of 5-hydroxyindole acetic acid and N-acetyl serotonin. In contrast, 5-HT metabolism in X. bocki appears more similar to common protostome 5-HT catabolic pathways.","language":"en","number":"15","urldate":"2021-07-27","journal":"Journal of Experimental Biology","author":[{"propositions":[],"lastnames":["Squires"],"firstnames":["Leah","N."],"suffixes":[]},{"propositions":[],"lastnames":["Rubakhin"],"firstnames":["Stanislav","S."],"suffixes":[]},{"propositions":[],"lastnames":["Wadhams"],"firstnames":["Andinet","Amare"],"suffixes":[]},{"propositions":[],"lastnames":["Talbot"],"firstnames":["Kristen","N."],"suffixes":[]},{"propositions":[],"lastnames":["Nakano"],"firstnames":["Hiroaki"],"suffixes":[]},{"propositions":[],"lastnames":["Moroz"],"firstnames":["Leonid","L."],"suffixes":[]},{"propositions":[],"lastnames":["Sweedler"],"firstnames":["Jonathan","V."],"suffixes":[]}],"month":"August","year":"2010","pages":"2647–2654","bibtex":"@article{squires_serotonin_2010,\n\ttitle = {Serotonin and its metabolism in basal deuterostomes: insights from \\textit{{Strongylocentrotus} purpuratus} and \\textit{{Xenoturbella} bocki}},\n\tvolume = {213},\n\tissn = {1477-9145, 0022-0949},\n\tshorttitle = {Serotonin and its metabolism in basal deuterostomes},\n\turl = {https://journals.biologists.com/jeb/article/213/15/2647/9729/Serotonin-and-its-metabolism-in-basal},\n\tdoi = {10.1242/jeb.042374},\n\tabstract = {SUMMARY\n Serotonin (5-HT), an important molecule in metazoans, is involved in a range of biological processes including neurotransmission and neuromodulation. Both its creation and release are tightly regulated, as is its removal. Multiple neurochemical pathways are responsible for the catabolism of 5-HT and are phyla specific; therefore, by elucidating these catabolic pathways we glean greater understanding of the relationships and origins of various transmitter systems. Here, 5-HT catabolic pathways were studied in Strongylocentrotus purpuratus and Xenoturbella bocki, two organisms occupying distinct positions in deuterostomes. The 5-HT-related compounds detected in these organisms were compared with those reported in other phyla. In S. purpuratus, 5-HT-related metabolites include N-acetyl serotonin, γ-glutamyl-serotonin and 5-hydroxyindole acetic acid; the quantity and type were found to vary based on the specific tissues analyzed. In addition to these compounds, varying levels of tryptamine were also seen. Upon addition of a 5-HT precursor and a monoamine oxidase inhibitor, 5-HT itself was detected. In similar experiments using X. bocki tissues, the 5-HT-related compounds found included 5-HT sulfate, γ-glutamyl-serotonin and 5-hydroxyindole acetic acid, as well as 5-HT and tryptamine. The sea urchin metabolizes 5-HT in a manner similar to both gastropod mollusks, as evidenced by the detection of γ-glutamyl-serotonin, and vertebrates, as indicated by the presence of 5-hydroxyindole acetic acid and N-acetyl serotonin. In contrast, 5-HT metabolism in X. bocki appears more similar to common protostome 5-HT catabolic pathways.},\n\tlanguage = {en},\n\tnumber = {15},\n\turldate = {2021-07-27},\n\tjournal = {Journal of Experimental Biology},\n\tauthor = {Squires, Leah N. and Rubakhin, Stanislav S. and Wadhams, Andinet Amare and Talbot, Kristen N. and Nakano, Hiroaki and Moroz, Leonid L. and Sweedler, Jonathan V.},\n\tmonth = aug,\n\tyear = {2010},\n\tpages = {2647--2654},\n}\n\n","author_short":["Squires, L. N.","Rubakhin, S. S.","Wadhams, A. A.","Talbot, K. N.","Nakano, H.","Moroz, L. L.","Sweedler, J. V."],"key":"squires_serotonin_2010","id":"squires_serotonin_2010","bibbaseid":"squires-rubakhin-wadhams-talbot-nakano-moroz-sweedler-serotoninanditsmetabolisminbasaldeuterostomesinsightsfromistrongylocentrotuspurpuratusiandixenoturbellabockii-2010","role":"author","urls":{"Paper":"https://journals.biologists.com/jeb/article/213/15/2647/9729/Serotonin-and-its-metabolism-in-basal"},"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://api.zotero.org/users/3476755/collections/4R6FPLUM/items?key=ckhubDoO51X1cQZZ35NkGdxk&format=bibtex&limit=100","dataSources":["sjcnwJbp7RFrMHX8Q"],"keywords":[],"search_terms":["serotonin","metabolism","basal","deuterostomes","insights","strongylocentrotus","purpuratus","xenoturbella","bocki","squires","rubakhin","wadhams","talbot","nakano","moroz","sweedler"],"title":"Serotonin and its metabolism in basal deuterostomes: insights from <i>Strongylocentrotus purpuratus</i> and <i>Xenoturbella bocki</i>","year":2010}