@article{
 title = {New Analysis of a Rat Feeding Study with a Genetically Modified Maize Reveals Signs of Hepatorenal Toxicity},
 type = {article},
 year = {2007},
 identifiers = {[object Object]},
 keywords = {ANALYSIS of variance,CORN,EUROPE,EVALUATION,FEMALES,GENETICALLY modified foods,HEALTH risk assessment,HEPATOTOXICOLOGY,MONSANTO Co.,RATS,URINE},
 pages = {596-602},
 volume = {52},
 websites = {10.1007/s00244-006-0149-5,http://search.ebscohost.com/login.aspx?direct=true&AuthType=ip,cookie,url,uid&db=eih&AN=24731977&loginpage=Login.asp&site=ehost-live&scope=site},
 publisher = {Springer Science & Business Media B.V.},
 id = {f5f80385-b335-382c-9f38-4583cca86edb},
 created = {2012-01-05T13:09:04.000Z},
 file_attached = {true},
 profile_id = {1a467167-0a41-3583-a6a3-034c31031332},
 group_id = {0e532975-1a47-38a4-ace8-4fe5968bcd72},
 last_modified = {2012-10-26T12:52:02.000Z},
 tags = {GMO Foods},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
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 source_type = {Journal Article},
 abstract = {Health risk assessment of genetically modified organisms (GMOs) cultivated for food or feed is under debate throughout the world, and very little data have been published on mid- or long-term toxicological studies with mammals. One of these studies performed under the responsibility of Monsanto Company with a transgenic corn MON863 has been subjected to questions from regulatory reviewers in Europe, where it was finally approved in 2005. This necessitated a new assessment of kidney pathological findings, and the results remained controversial. An Appeal Court action in Germany (Münster) allowed public access in June 2005 to all the crude data from this 90-day rat-feeding study. We independently re-analyzed these data. Appropriate statistics were added, such as a multivariate analysis of the growth curves, and for biochemical parameters comparisons between GMO-treated rats and the controls fed with an equivalent normal diet, and separately with six reference diets with different compositions. We observed that after the consumption of MON863, rats showed slight but dose-related significant variations in growth for both sexes, resulting in 3.3% decrease in weight for males and 3.7% increase for females. Chemistry measurements reveal signs of hepatorenal toxicity, marked also by differential sensitivities in males and females. Triglycerides increased by 24–40% in females (either at week 14, dose 11% or at week 5, dose 33%, respectively); urine phosphorus and sodium excretions diminished in males by 31–35% (week 14, dose 33%) for the most important results significantly linked to the treatment in comparison to seven diets tested. Longer experiments are essential in order to indicate the real nature and extent of the possible pathology; with the present data it cannot be concluded that GM corn MON863 is a safe product. [ABSTRACT FROM AUTHOR] Copyright of Archives of Environmental Contamination & Toxicology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)},
 bibtype = {article},
 author = {Séralini, Gilles-Eric and Cellier, Dominique and Vendomois, Joël},
 journal = {Archives of Environmental Contamination & Toxicology},
 number = {4}
}

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Chemistry measurements reveal signs of hepatorenal toxicity, marked also by differential sensitivities in males and females. Triglycerides increased by 24–40% in females (either at week 14, dose 11% or at week 5, dose 33%, respectively); urine phosphorus and sodium excretions diminished in males by 31–35% (week 14, dose 33%) for the most important results significantly linked to the treatment in comparison to seven diets tested. Longer experiments are essential in order to indicate the real nature and extent of the possible pathology; with the present data it cannot be concluded that GM corn MON863 is a safe product. [ABSTRACT FROM AUTHOR] Copyright of Archives of Environmental Contamination & Toxicology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. 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