Rates and Predictors of Conversion to Schizophrenia or Bipolar Disorder Following Substance-Induced Psychosis. Starzer, M. S. K., Nordentoft, M., & Hjorthøj, C. American Journal of Psychiatry, 175(4):343–350, 2017. ![Rates and Predictors of Conversion to Schizophrenia or Bipolar Disorder Following Substance-Induced Psychosis [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Objective:The authors investigated the rates of conversion to schizophrenia and bipolar disorder after a substance-induced psychosis, as well as risk factors for conversion.Method:All patient information was extracted from the Danish Civil Registration System and the Psychiatric Central Research Register. The study population included all persons who received a diagnosis of substance-induced psychosis between 1994 and 2014 (N=6,788); patients were followed until first occurrence of schizophrenia or bipolar disorder or until death, emigration, or August 2014. The Kaplan-Meier method was used to obtain cumulative probabilities for the conversion from a substance-induced psychosis to schizophrenia or bipolar disorder. Cox proportional hazards regression models were used to calculate hazard ratios for all covariates.Results:Overall, 32.2% (95% CI=29.7–34.9) of patients with a substance-induced psychosis converted to either bipolar or schizophrenia-spectrum disorders. The highest conversion rate was found for cannabis-induced psychosis, with 47.4% (95% CI=42.7–52.3) converting to either schizophrenia or bipolar disorder. Young age was associated with a higher risk of converting to schizophrenia. Self-harm after a substance-induced psychosis was significantly linked to a higher risk of converting to both schizophrenia and bipolar disorder. Half the cases of conversion to schizophrenia occurred within 3.1 years after a substance-induced psychosis, and half the cases of conversion to bipolar disorder occurred within 4.4 years.Conclusions:Substance-induced psychosis is strongly associated with the development of severe mental illness, and a long follow-up period is needed to identify the majority of cases.
@article{starzer_rates_2017,
title = {Rates and {Predictors} of {Conversion} to {Schizophrenia} or {Bipolar} {Disorder} {Following} {Substance}-{Induced} {Psychosis}},
volume = {175},
issn = {0002-953X},
url = {https://ajp.psychiatryonline.org/doi/abs/10.1176/appi.ajp.2017.17020223},
doi = {10.1176/appi.ajp.2017.17020223},
abstract = {Objective:The authors investigated the rates of conversion to schizophrenia and bipolar disorder after a substance-induced psychosis, as well as risk factors for conversion.Method:All patient information was extracted from the Danish Civil Registration System and the Psychiatric Central Research Register. The study population included all persons who received a diagnosis of substance-induced psychosis between 1994 and 2014 (N=6,788); patients were followed until first occurrence of schizophrenia or bipolar disorder or until death, emigration, or August 2014. The Kaplan-Meier method was used to obtain cumulative probabilities for the conversion from a substance-induced psychosis to schizophrenia or bipolar disorder. Cox proportional hazards regression models were used to calculate hazard ratios for all covariates.Results:Overall, 32.2\% (95\% CI=29.7–34.9) of patients with a substance-induced psychosis converted to either bipolar or schizophrenia-spectrum disorders. The highest conversion rate was found for cannabis-induced psychosis, with 47.4\% (95\% CI=42.7–52.3) converting to either schizophrenia or bipolar disorder. Young age was associated with a higher risk of converting to schizophrenia. Self-harm after a substance-induced psychosis was significantly linked to a higher risk of converting to both schizophrenia and bipolar disorder. Half the cases of conversion to schizophrenia occurred within 3.1 years after a substance-induced psychosis, and half the cases of conversion to bipolar disorder occurred within 4.4 years.Conclusions:Substance-induced psychosis is strongly associated with the development of severe mental illness, and a long follow-up period is needed to identify the majority of cases.},
number = {4},
urldate = {2018-05-10},
journal = {American Journal of Psychiatry},
author = {Starzer, Marie Stefanie Kejser and Nordentoft, Merete and Hjorthøj, Carsten},
year = {2017},
keywords = {Documents généraux sur les troubles concomitants},
pages = {343--350},
}
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The study population included all persons who received a diagnosis of substance-induced psychosis between 1994 and 2014 (N=6,788); patients were followed until first occurrence of schizophrenia or bipolar disorder or until death, emigration, or August 2014. The Kaplan-Meier method was used to obtain cumulative probabilities for the conversion from a substance-induced psychosis to schizophrenia or bipolar disorder. Cox proportional hazards regression models were used to calculate hazard ratios for all covariates.Results:Overall, 32.2% (95% CI=29.7–34.9) of patients with a substance-induced psychosis converted to either bipolar or schizophrenia-spectrum disorders. The highest conversion rate was found for cannabis-induced psychosis, with 47.4% (95% CI=42.7–52.3) converting to either schizophrenia or bipolar disorder. Young age was associated with a higher risk of converting to schizophrenia. Self-harm after a substance-induced psychosis was significantly linked to a higher risk of converting to both schizophrenia and bipolar disorder. Half the cases of conversion to schizophrenia occurred within 3.1 years after a substance-induced psychosis, and half the cases of conversion to bipolar disorder occurred within 4.4 years.Conclusions:Substance-induced psychosis is strongly associated with the development of severe mental illness, and a long follow-up period is needed to identify the majority of cases.","number":"4","urldate":"2018-05-10","journal":"American Journal of Psychiatry","author":[{"propositions":[],"lastnames":["Starzer"],"firstnames":["Marie","Stefanie","Kejser"],"suffixes":[]},{"propositions":[],"lastnames":["Nordentoft"],"firstnames":["Merete"],"suffixes":[]},{"propositions":[],"lastnames":["Hjorthøj"],"firstnames":["Carsten"],"suffixes":[]}],"year":"2017","keywords":"Documents généraux sur les troubles concomitants","pages":"343–350","bibtex":"@article{starzer_rates_2017,\n\ttitle = {Rates and {Predictors} of {Conversion} to {Schizophrenia} or {Bipolar} {Disorder} {Following} {Substance}-{Induced} {Psychosis}},\n\tvolume = {175},\n\tissn = {0002-953X},\n\turl = {https://ajp.psychiatryonline.org/doi/abs/10.1176/appi.ajp.2017.17020223},\n\tdoi = {10.1176/appi.ajp.2017.17020223},\n\tabstract = {Objective:The authors investigated the rates of conversion to schizophrenia and bipolar disorder after a substance-induced psychosis, as well as risk factors for conversion.Method:All patient information was extracted from the Danish Civil Registration System and the Psychiatric Central Research Register. The study population included all persons who received a diagnosis of substance-induced psychosis between 1994 and 2014 (N=6,788); patients were followed until first occurrence of schizophrenia or bipolar disorder or until death, emigration, or August 2014. The Kaplan-Meier method was used to obtain cumulative probabilities for the conversion from a substance-induced psychosis to schizophrenia or bipolar disorder. Cox proportional hazards regression models were used to calculate hazard ratios for all covariates.Results:Overall, 32.2\\% (95\\% CI=29.7–34.9) of patients with a substance-induced psychosis converted to either bipolar or schizophrenia-spectrum disorders. The highest conversion rate was found for cannabis-induced psychosis, with 47.4\\% (95\\% CI=42.7–52.3) converting to either schizophrenia or bipolar disorder. Young age was associated with a higher risk of converting to schizophrenia. 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