The Challenge of Regulation in a Minimal Photoautotroph: Non-Coding RNAs in Prochlorococcus. Steglich, C., Futschik, M. E., Lindell, D., Voß, B., Chisholm, S. W., & Hess, W. R. PLoS Genet, 4(8):e1000173, 2008. 00069![The Challenge of Regulation in a Minimal Photoautotroph: Non-Coding RNAs in Prochlorococcus [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Prochlorococcus is the most abundant phototroph in the vast, nutrient-poor areas of the ocean. It plays an important role in the ocean carbon cycle, and is a key component of the base of the food web. All cells share a core set of about 1,200 genes, augmented with a variable number of “flexible” genes. Many of the latter are located in genomic islands—hypervariable regions of the genome that encode functions important in differentiating the niches of “ecotypes.” Of major interest is how cells with such a small genome regulate cellular processes, as they lack many of the regulatory proteins commonly found in bacteria. We show here that contrary to the regulatory proteins, ncRNAs are present at levels typical of bacteria, revealing that they might have a disproportional regulatory role in Prochlorococcus—likely an adaptation to the extremely low-nutrient conditions of the open oceans, combined with the constraints of a small genome. Some of the ncRNAs were differentially expressed under stress conditions, and a high number of them were found to be associated with genomic islands, suggesting functional links between these RNAs and the response of Prochlorococcus to particular environmental challenges.
@article{steglich_challenge_2008,
title = {The {Challenge} of {Regulation} in a {Minimal} {Photoautotroph}: {Non}-{Coding} {RNAs} in {Prochlorococcus}},
volume = {4},
shorttitle = {The {Challenge} of {Regulation} in a {Minimal} {Photoautotroph}},
url = {http://dx.doi.org/10.1371%2Fjournal.pgen.1000173},
doi = {10.1371%2Fjournal.pgen.1000173},
abstract = {Prochlorococcus is the most abundant phototroph in the vast, nutrient-poor areas of the ocean. It plays an important role in the ocean carbon cycle, and is a key component of the base of the food web. All cells share a core set of about 1,200 genes, augmented with a variable number of “flexible” genes. Many of the latter are located in genomic islands—hypervariable regions of the genome that encode functions important in differentiating the niches of “ecotypes.” Of major interest is how cells with such a small genome regulate cellular processes, as they lack many of the regulatory proteins commonly found in bacteria. We show here that contrary to the regulatory proteins, ncRNAs are present at levels typical of bacteria, revealing that they might have a disproportional regulatory role in Prochlorococcus—likely an adaptation to the extremely low-nutrient conditions of the open oceans, combined with the constraints of a small genome. Some of the ncRNAs were differentially expressed under stress conditions, and a high number of them were found to be associated with genomic islands, suggesting functional links between these RNAs and the response of Prochlorococcus to particular environmental challenges.},
number = {8},
urldate = {2009-03-10},
journal = {PLoS Genet},
author = {Steglich, Claudia and Futschik, Matthias E. and Lindell, Debbie and Voß, Bjoern and Chisholm, Sallie W. and Hess, Wolfgang R.},
year = {2008},
note = {00069},
pages = {e1000173}
}
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