The role of heterogeneities and intercellular coupling in wave propagation in cardiac tissue. Steinberg, B., Glass, L., Shrier, A., & Bub, G. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 2006.
abstract   bibtex   
Electrical heterogeneities play a role in the initiation of cardiac arrhythmias. In certain pathological conditions such as ischaemia, current sinks can develop in the diseased cardiac tissue. In this study, we investigate the effects of changing the amount of heterogeneity and intercellular coupling on wavefront stability in a cardiac cell culture system and a mathematical model of excitable media. In both systems, we observe three types of behaviour: plane wave propagation without breakup, plane wave breakup into spiral waves and plane wave block. In the theoretical model, we observe a linear decrease in propagation velocity as the number of heterogeneities is increased, followed by a rapid, nonlinear decrease to zero. The linear decrease results from the heterogeneities acting independently on the wavefront. A general scaling argument that considers the degree of system heterogeneity and the properties of the excitable medium is used to derive a dimensionless parameter that describes the interaction of the wavefront with the heterogeneities. © 2006 The Royal Society.
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 title = {The role of heterogeneities and intercellular coupling in wave propagation in cardiac tissue},
 type = {article},
 year = {2006},
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 keywords = {[Cardiac arrhythmia, Excitable media, FitzHugh-Nag},
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 abstract = {Electrical heterogeneities play a role in the initiation of cardiac arrhythmias. In certain pathological conditions such as ischaemia, current sinks can develop in the diseased cardiac tissue. In this study, we investigate the effects of changing the amount of heterogeneity and intercellular coupling on wavefront stability in a cardiac cell culture system and a mathematical model of excitable media. In both systems, we observe three types of behaviour: plane wave propagation without breakup, plane wave breakup into spiral waves and plane wave block. In the theoretical model, we observe a linear decrease in propagation velocity as the number of heterogeneities is increased, followed by a rapid, nonlinear decrease to zero. The linear decrease results from the heterogeneities acting independently on the wavefront. A general scaling argument that considers the degree of system heterogeneity and the properties of the excitable medium is used to derive a dimensionless parameter that describes the interaction of the wavefront with the heterogeneities. © 2006 The Royal Society.},
 bibtype = {article},
 author = {Steinberg, B.E. and Glass, L. and Shrier, A. and Bub, G.},
 journal = {Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences},
 number = {1842}
}

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